https://wikem.org/w/api.php?action=feedcontributions&feedformat=atom&user=Jsitzmann 2026-05-01T01:25:17Z User contributions MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Template:Immunosuppressant_medication_complications&diff=92217 2016-08-01T21:51:49Z

<p>Jsitzmann: /* Complications Due to Immunosuppressant Medications */</p> <hr /> <div>===Immunosuppressant Medications===<br /> *Balance between immune suppression, rejection and susceptibility to infection<br /> *Typical regimen includes: calcineurin inhibitor + antimetabolite + steroid<br /> **Calcineurin inhibitor<br /> ***Cyclosporine<br /> ***Tacrolimus<br /> **Antimetabolite<br /> ***Azathioprine<br /> ***Mycophenolate Mofetil (MMF)<br /> **[[Steroids]]<br /> ***[[Prednisone]]/[[Prednisolone]]</div>

Jsitzmann https://wikem.org/w/index.php?title=Template:Transplant_emergency_types&diff=92216 2016-08-01T21:50:57Z

<p>Jsitzmann: /* Types of Transplant complications */</p> <hr /> <div>===Types of [[Transplant complications]]===<br /> <br /> *Immediate (0-1 week)<br /> **Acute Tubular Necrosis<br /> ***May be post-ischemic, commonly effecting both the proximal tubules and the thick ascending limb. Or it may be immunosupresive drug induced and only effect the proximal tubules. Granular &quot;muddy brown casts&quot; seen on urinalysis result from death and sloughing of tubular cells. <br /> **Antibody mediated rejection<br /> ***Results from donor specific antibodies including as ABO isoagglutinins. <br /> ***Usually results in graft loss within 24 hours.<br /> **Embolization and Thrombosis <br /> ***May arise with or without rejection<br /> ***May result from hypotension, anastomotic stenosis, arterial dissection, kinking of transplanted artery, or angulation of the vein<br /> **Calcium Oxalate deposition<br /> **Delayed graft function<br /> ***This is defined as renal failure persisting after transplantation necessitating dialysis. It my be due to post-ischemic acute tubular necrosis, volume depletion, or volume depletion. <br /> **Urinary bladder dysfunction<br /> ***This complication is especially common in diabetics and may cause hydronephrosis <br /> <br /> *Early (1-12 weeks)<br /> **Acute rejection<br /> ***Antibodies against donor kidney develop after transplant<br /> ***Dense interstitial lymphocytic infiltrate <br /> ***Prevent/reverse with immunosuppressants <br /> **Immunosuppressive Cytotoxicity <br /> ***Usually caused by calcineurin inhibitor toxicity<br /> ***Reverse by decrease dosage of immunosuppressants <br /> **Infection<br /> ***Most commonly polyoma (BK virus) or cytomegalovirus (CMV)<br /> ***Polyoma virus is treated with intravenous immunoglobulins <br /> ***CMV is treated with antivirals medications<br /> **Recurrence of primary disease<br /> <br /> *Late Acute (greater than 3 months)<br /> **Hypertension<br /> ***Hypertension is common in ESRD/CKD patients and often worsens after transplant <br /> ***Can result in decreased allograft survival<br /> **Renal artery stenosis <br /> ***Important to identify because is a correctible cause of post-transplant hypertension<br /> **Acute Rejection<br /> ***Same as above<br /> **Immunosuppressive cytotoxicity <br /> ***Same as above <br /> <br /> *Late Chronic (years later)<br /> **Chronic allograft nephropathy <br /> ***Irreversible T-cell and antibody mediated damage<br /> ***Causes vascular fibrosis<br /> **Immunosuppressive cytotoxicity<br /> ***Same as above</div>

Jsitzmann https://wikem.org/w/index.php?title=Kidney_transplant_complications&diff=92209 2016-08-01T21:32:55Z

<p>Jsitzmann: /* Clinical Features */</p> <hr /> <div>==Background==<br /> *most commonly transplanted organ<br /> <br /> {{Transplant emergency types}}<br /> <br /> {{Immunosuppressant medication complications}}<br /> <br /> ==Clinical Features==<br /> The clinical features will depend on the type of complication and the amount of time elapsed post-transplantation.<br /> <br /> Hyperacute Rejection<br /> *Little or no urine output<br /> *Widespread thrombosis<br /> <br /> Early<br /> *Symptoms of infection<br /> *Symptoms of recurrent disease<br /> *Decreased urine output<br /> *Hemorrhagic or non-hemorrhagic cystitis <br /> <br /> Late Acute<br /> *Symptoms of infection<br /> *Symptoms of recurrent disease<br /> *Decreased urine output<br /> *Hemorrhagic or non-hemorrhagic cystitis <br /> <br /> Late Chronic<br /> *Symptoms of infection<br /> *Symptoms of recurrent disease<br /> *Decreased urine output<br /> *Hemorrhagic or non-hemorrhagic cystitis<br /> <br /> ==Differential Diagnosis==<br /> <br /> ==Evaluation==<br /> *Creatinine best prognostic marker of graft function<br /> <br /> ==Management==<br /> <br /> ==Disposition==<br /> <br /> ==See Also==<br /> *[[Transplant complications]]<br /> <br /> ==External Links==<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Renal]]</div>

Jsitzmann https://wikem.org/w/index.php?title=Kidney_transplant_complications&diff=92201 2016-08-01T21:15:22Z

<p>Jsitzmann: /* Clinical Features */</p> <hr /> <div>==Background==<br /> *most commonly transplanted organ<br /> <br /> {{Transplant emergency types}}<br /> <br /> {{Immunosuppressant medication complications}}<br /> <br /> ==Clinical Features==<br /> The clinical features will depend on the type of complication and the amount of time elapsed post-transplantation.<br /> <br /> ==Differential Diagnosis==<br /> <br /> ==Evaluation==<br /> *Creatinine best prognostic marker of graft function<br /> <br /> ==Management==<br /> <br /> ==Disposition==<br /> <br /> ==See Also==<br /> *[[Transplant complications]]<br /> <br /> ==External Links==<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Renal]]</div>

Jsitzmann https://wikem.org/w/index.php?title=Template:Transplant_emergency_types&diff=92198 2016-08-01T21:14:45Z

<p>Jsitzmann: /* Types of Transplant complications */</p> <hr /> <div>===Types of [[Transplant complications]]===<br /> <br /> *Immediate (0-1 week)<br /> **Acute Tubular Necrosis<br /> ***May be post-ischemic, commonly effecting both the proximal tubules and the thick ascending limb. Or it may be immunosupresive drug induced and only effect the proximal tubules. Granular &quot;muddy brown casts&quot; seen on urinalysis result from death and sloughing of tubular cells. <br /> **Antibody mediated rejection<br /> ***Results from donor specific antibodies including as ABO isoagglutinins. <br /> ***Usually results in graft loss within 24 hours.<br /> **Embolization and Thrombosis <br /> ***May arise with or without rejection<br /> ***May result from hypotension, anastomotic stenosis, arterial dissection, kinking of transplanted artery, or angulation of the vein<br /> **Calcium Oxalate deposition<br /> **Delayed graft function<br /> ***This is defined as renal failure persisting after transplantation necessitating dialysis. It my be due to post-ischemic acute tubular necrosis, volume depletion, or volume depletion. <br /> **Urinary bladder dysfunction<br /> ***This complication is especially common in diabetics and may cause hydronephrosis <br /> <br /> *Early (1-12 weeks)<br /> **Acute rejection<br /> **Immunosuppressive Cytotoxicity <br /> ***Usually caused by calcineurin inhibitor toxicity<br /> **Infection<br /> **Recurrence of primary disease<br /> <br /> *Late Acute (greater than 3 months)<br /> **Hypertension<br /> **Renal artery stenosis <br /> **Acute Rejection<br /> **Immunosuppressive cytotoxicity <br /> <br /> *Late Chronic (years later)<br /> **Chronic allograph nephropathy <br /> **Immunosuppressive cytotoxicity<br /> **<br /> <br /> <br /> <br /> <br /> <br /> *transplant-related infection<br /> *medication side effects<br /> *rejection<br /> *[[graft-versus-host disease]]<br /> *postoperative complications and complications of altered physiology secondary to the transplanted organ<br /> *Normal medical problems requiring unique management due to altered physiology &lt;ref&gt;Tintinalli's&lt;/ref&gt;<br /> <br /> &lt;references/&gt;</div>

Jsitzmann https://wikem.org/w/index.php?title=Template:Transplant_emergency_types&diff=92195 2016-08-01T21:13:40Z

<p>Jsitzmann: /* Types of Transplant complications */</p> <hr /> <div>===Types of [[Transplant complications]]===<br /> *transplant-related infection<br /> *medication side effects<br /> *rejection<br /> *[[graft-versus-host disease]]<br /> *postoperative complications and complications of altered physiology secondary to the transplanted organ<br /> *Normal medical problems requiring unique management due to altered physiology &lt;ref&gt;Tintinalli's&lt;/ref&gt;<br /> <br /> &lt;references/&gt;</div>

Jsitzmann https://wikem.org/w/index.php?title=Template:Transplant_emergency_types&diff=92194 2016-08-01T21:12:57Z

<p>Jsitzmann: /* Types of Transplant complications */</p> <hr /> <div>===Types of [[Transplant complications]]===<br /> *transplant-related infection<br /> *medication side effects<br /> *rejection<br /> *[[graft-versus-host disease]]<br /> *postoperative complications and complications of altered physiology secondary to the transplanted organ<br /> *Normal medical problems requiring unique management due to altered physiology &lt;ref&gt;Tintinalli's&lt;/ref&gt;</div>

Jsitzmann https://wikem.org/w/index.php?title=Template:Transplant_emergency_types&diff=92193 2016-08-01T21:10:05Z

<p>Jsitzmann: /* Types of Transplant Complications */</p> <hr /> <div>===Types of [[Transplant complications]]===<br /> <br /> *Immediate (0-1 week)<br /> **Acute Tubular Necrosis<br /> ***May be post-ischemic, commonly effecting both the proximal tubules and the thick ascending limb. Or it may be immunosupresive drug induced and only effect the proximal tubules. Granular &quot;muddy brown casts&quot; seen on urinalysis result from death and sloughing of tubular cells. <br /> **Antibody mediated rejection<br /> ***Results from donor specific antibodies including as ABO isoagglutinins. <br /> ***Usually results in graft loss within 24 hours.<br /> **Embolization and Thrombosis <br /> ***May arise with or without rejection<br /> ***May result from hypotension, anastomotic stenosis, arterial dissection, kinking of transplanted artery, or angulation of the vein<br /> **Calcium Oxalate deposition<br /> **Delayed graft function<br /> ***This is defined as renal failure persisting after transplantation necessitating dialysis. It my be due to post-ischemic acute tubular necrosis, volume depletion, or volume depletion. <br /> **Urinary bladder dysfunction<br /> ***This complication is especially common in diabetics and may cause hydronephrosis <br /> <br /> *Early (1-12 weeks)<br /> **Acute rejection<br /> **Immunosuppressive Cytotoxicity <br /> ***Usually caused by calcineurin inhibitor toxicity<br /> **Infection<br /> **Recurrence of primary disease<br /> <br /> *Late Acute (greater than 3 months)<br /> **Hypertension<br /> **Renal artery stenosis <br /> **Acute Rejection<br /> **Immunosuppressive cytotoxicity <br /> <br /> *Late Chronic (years later)<br /> **Chronic allograph nephropathy <br /> **Immunosuppressive cytotoxicity<br /> **<br /> <br /> <br /> <br /> <br /> <br /> <br /> <br /> *transplant-related infection<br /> *medication side effects<br /> *rejection<br /> *[[graft-versus-host disease]]<br /> *postoperative complications and complications of altered physiology secondary to the transplanted organ<br /> *Normal medical problems requiring unique management due to altered physiology &lt;ref&gt;Tintinalli's&lt;/ref&gt;</div>

Jsitzmann https://wikem.org/w/index.php?title=Kidney_transplant_complications&diff=92190 2016-08-01T21:05:49Z

<p>Jsitzmann: /* Clinical Features */</p> <hr /> <div>==Background==<br /> *most commonly transplanted organ<br /> <br /> {{Transplant emergency types}}<br /> <br /> {{Immunosuppressant medication complications}}<br /> <br /> ==Clinical Features==<br /> The clinical features will depend on the type of complication and the amount of time elapsed post-transplantation.<br /> <br /> *Immediate (0-1 week)<br /> **Acute Tubular Necrosis<br /> ***May be post-ischemic, commonly effecting both the proximal tubules and the thick ascending limb. Or it may be immunosupresive drug induced and only effect the proximal tubules. Granular &quot;muddy brown casts&quot; seen on urinalysis result from death and sloughing of tubular cells. <br /> **Antibody mediated rejection<br /> ***Results from donor specific antibodies including as ABO isoagglutinins. <br /> ***Usually results in graft loss within 24 hours.<br /> **Embolization and Thrombosis <br /> ***May arise with or without rejection<br /> ***May result from hypotension, anastomotic stenosis, arterial dissection, kinking of transplanted artery, or angulation of the vein<br /> **Calcium Oxalate deposition<br /> **Delayed graft function<br /> ***This is defined as renal failure persisting after transplantation necessitating dialysis. It my be due to post-ischemic acute tubular necrosis, volume depletion, or volume depletion. <br /> **Urinary bladder dysfunction<br /> ***This complication is especially common in diabetics and may cause hydronephrosis <br /> <br /> *Early (1-12 weeks)<br /> **Acute rejection<br /> **Immunosuppressive Cytotoxicity <br /> ***Usually caused by calcineurin inhibitor toxicity<br /> **Infection<br /> **Recurrence of primary disease<br /> <br /> *Late Acute (greater than 3 months)<br /> **Hypertension<br /> **Renal artery stenosis <br /> **Acute Rejection<br /> **Immunosuppressive cytotoxicity <br /> <br /> *Late Chronic (years later)<br /> **Chronic allograph nephropathy <br /> **Immunosuppressive cytotoxicity<br /> **<br /> <br /> ==Differential Diagnosis==<br /> <br /> ==Evaluation==<br /> *Creatinine best prognostic marker of graft function<br /> <br /> ==Management==<br /> <br /> ==Disposition==<br /> <br /> ==See Also==<br /> *[[Transplant complications]]<br /> <br /> ==External Links==<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Renal]]</div>

Jsitzmann