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2026-05-14T03:50:18Z
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https://wikem.org/w/index.php?title=Psilocybin_toxicity&diff=112080
Psilocybin toxicity
2016-11-26T21:17:01Z
<p>Lwmerwin: /* Intoxication Treatment */</p>
<hr />
<div>== Psilocybin ==<br />
A compound found in over 200 mushrooms that has mind altering properties similar to LSD. Commonly known as "magic mushrooms" or "shrooms". The mushroom are often taken recreationally for the euphoric and hallucinogenic effects. Typically grown in the Pacific Northwest and southern regions of the United States. For a typical dose (1mg) symptoms will last 1-3 hours.<br />
<br />
== Signs/Symptoms==<br />
* Euphoria<br />
* Visual hallucinations<br />
* Lethargy<br />
* Depression<br />
* Synesthesia<br />
<br />
=== Physical Effects ===<br />
* Pupil Dilation<br />
* Tachycardia<br />
* Hypertension<br />
* Hypotension<br />
* Nausea<br />
<br />
==Differential Diagnosis==<br />
* Hypoglycemia<br />
* TBI<br />
* Other drugs of abuse<br />
* CO poisoning<br />
* Meningitis/Encephalitis<br />
* Opioid intoxication<br />
* Antihistamines/Anticholinergics intoxication<br />
<br />
== Adverse Effects ==<br />
* Anxiety<br />
* Confusion<br />
* Disorientation<br />
* Agitation<br />
* Accidents<br />
<br />
=== Toxicity ===<br />
* Low<br />
* 280mg/kg<br />
* Therapeutic index of 641<br />
<br />
==Evaluation==<br />
* Clinical Diagnosis<br />
* Urine toxin screen if concerned about co-ingestion<br />
<br />
== Management ==<br />
* Supportive Care<br />
* Place patient in a calm and quiet environment<br />
* Monitor Vitals<br />
* If worsening vitals or agitation treat with Benzodiazepines<br />
* Can be discharged if symptoms abate and vitals normalize<br />
<br />
===Disposition===<br />
* Discharge when clinically sober<br />
<br />
== Refrences ==<br />
* Nichols DE. Hallucinogens. Pharmacol Ther 2004; 101:131.<br />
* UpToDate<br />
* van Amsterdam J, Opperhuizen A, van den Brink W (2011). "Harm potential of magic mushroom use: a review" (PDF). Regulatory Toxicology and Pharmacology. 59 (3): 423–9. doi:10.1016/j.yrtph.2011.01.006. PMID 21256914.<br />
* Merck Index, 11th Edition, 7942<br />
* "Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867.<br />
* Passie T, Seifert J, Schneider U, Emrich HM (2002). "The pharmacology of psilocybin". Addiction Biology. 7 (4): 357–64. doi:10.1080/1355621021000005937. PMID 14578010.<br />
"Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867.<br />
* Halpern JH1. "Hallucinogens and dissociative agents naturally growing in the United States." Pharmacol Ther. 2004 May;102(2):131-8.</div>
Lwmerwin
https://wikem.org/w/index.php?title=Psilocybin_toxicity&diff=112079
Psilocybin toxicity
2016-11-26T21:14:22Z
<p>Lwmerwin: /* Signs/Symptoms */</p>
<hr />
<div>== Psilocybin ==<br />
A compound found in over 200 mushrooms that has mind altering properties similar to LSD. Commonly known as "magic mushrooms" or "shrooms". The mushroom are often taken recreationally for the euphoric and hallucinogenic effects. Typically grown in the Pacific Northwest and southern regions of the United States. For a typical dose (1mg) symptoms will last 1-3 hours.<br />
<br />
== Signs/Symptoms==<br />
* Euphoria<br />
* Visual hallucinations<br />
* Lethargy<br />
* Depression<br />
* Synesthesia<br />
<br />
=== Physical Effects ===<br />
* Pupil Dilation<br />
* Tachycardia<br />
* Hypertension<br />
* Hypotension<br />
* Nausea<br />
<br />
==Differential Diagnosis==<br />
* Hypoglycemia<br />
* TBI<br />
* Other drugs of abuse<br />
* CO poisoning<br />
* Meningitis/Encephalitis<br />
* Opioid intoxication<br />
* Antihistamines/Anticholinergics intoxication<br />
<br />
== Adverse Effects ==<br />
* Anxiety<br />
* Confusion<br />
* Disorientation<br />
* Agitation<br />
* Accidents<br />
<br />
=== Toxicity ===<br />
* Low<br />
* 280mg/kg<br />
* Therapeutic index of 641<br />
<br />
== Intoxication Treatment ==<br />
* Supportive Care<br />
* Pt's placed in a calm, quiet environment<br />
* Monitor Vitals<br />
* If worsening vitals or agitation treat with Benzodiazepines<br />
* Can be discharged if symptoms abate and vitals normalize<br />
<br />
== Refrences ==<br />
* Nichols DE. Hallucinogens. Pharmacol Ther 2004; 101:131.<br />
* UpToDate<br />
* van Amsterdam J, Opperhuizen A, van den Brink W (2011). "Harm potential of magic mushroom use: a review" (PDF). Regulatory Toxicology and Pharmacology. 59 (3): 423–9. doi:10.1016/j.yrtph.2011.01.006. PMID 21256914.<br />
* Merck Index, 11th Edition, 7942<br />
* "Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867.<br />
* Passie T, Seifert J, Schneider U, Emrich HM (2002). "The pharmacology of psilocybin". Addiction Biology. 7 (4): 357–64. doi:10.1080/1355621021000005937. PMID 14578010.<br />
"Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867.<br />
* Halpern JH1. "Hallucinogens and dissociative agents naturally growing in the United States." Pharmacol Ther. 2004 May;102(2):131-8.</div>
Lwmerwin
https://wikem.org/w/index.php?title=Psilocybin_toxicity&diff=111390
Psilocybin toxicity
2016-11-21T04:59:49Z
<p>Lwmerwin: </p>
<hr />
<div>== Psilocybin ==<br />
A compound found in over 200 mushrooms that has mind altering properties similar to LSD. Commonly known as "magic mushrooms" or "shrooms". The mushroom are often taken recreationally for the euphoric and hallucinogenic effects. Typically grown in the Pacific Northwest and southern regions of the United States. For a typical dose (1mg) symptoms will last 1-3 hours.<br />
<br />
== Signs/Symptoms ==<br />
* Euphoria<br />
* Visual hallucinations<br />
* Lethargy<br />
* Depression<br />
* Synesthesia<br />
<br />
=== Physical Effects ===<br />
* Pupil Dilation<br />
* Tachycardia<br />
* Hypertension<br />
* Hypotension<br />
* Nausea<br />
<br />
== Adverse Effects ==<br />
* Anxiety<br />
* Confusion<br />
* Disorientation<br />
* Agitation<br />
* Accidents<br />
<br />
=== Toxicity ===<br />
* Low<br />
* 280mg/kg<br />
* Therapeutic index of 641<br />
<br />
== Intoxication Treatment ==<br />
* Supportive Care<br />
* Pt's placed in a calm, quiet environment<br />
* Monitor Vitals<br />
* If worsening vitals or agitation treat with Benzodiazepines<br />
* Can be discharged if symptoms abate and vitals normalize<br />
<br />
== Refrences ==<br />
* Nichols DE. Hallucinogens. Pharmacol Ther 2004; 101:131.<br />
* UpToDate<br />
* van Amsterdam J, Opperhuizen A, van den Brink W (2011). "Harm potential of magic mushroom use: a review" (PDF). Regulatory Toxicology and Pharmacology. 59 (3): 423–9. doi:10.1016/j.yrtph.2011.01.006. PMID 21256914.<br />
* Merck Index, 11th Edition, 7942<br />
* "Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867.<br />
* Passie T, Seifert J, Schneider U, Emrich HM (2002). "The pharmacology of psilocybin". Addiction Biology. 7 (4): 357–64. doi:10.1080/1355621021000005937. PMID 14578010.<br />
"Comparison of acute lethal toxicity of commonly abused psychoactive substances" (PDF). Addiction. 99 (6): 686–96. doi:10.1111/j.1360-0443.2004.00744.x. PMID 15139867.<br />
* Halpern JH1. "Hallucinogens and dissociative agents naturally growing in the United States." Pharmacol Ther. 2004 May;102(2):131-8.</div>
Lwmerwin
https://wikem.org/w/index.php?title=Psilocybin_toxicity&diff=111365
Psilocybin toxicity
2016-11-21T01:22:08Z
<p>Lwmerwin: Created page with "== Psilocybin == A compound found in over 200 mushrooms that has mind altering properties similar to LSD. Commonly known as "magic mushrooms" or "shrooms". The mushroom are of..."</p>
<hr />
<div>== Psilocybin ==<br />
A compound found in over 200 mushrooms that has mind altering properties similar to LSD. Commonly known as "magic mushrooms" or "shrooms". The mushroom are often taken recreationally for the euphoric and hallucinogenic effects. Typically grown in the Pacific Northwest and southern regions of the United States. For a typical dose (1mg) symptoms will last 1-3 hours.<br />
<br />
== Signs/Symptoms ==<br />
* Euphoria<br />
* Visual hallucinations<br />
* Lethargy<br />
* Depression<br />
* Synesthesia<br />
<br />
=== Physical Effects ===<br />
* Pupil Dilation<br />
* Tachycardia<br />
* Hypertension<br />
* Hypotension<br />
* Nausea<br />
<br />
== Adverse Effects ==<br />
* Anxiety<br />
* Confusion<br />
* Disorientation<br />
* Agitation<br />
* Accidents<br />
<br />
=== Toxicity ===<br />
* Low<br />
* 280mg/kg<br />
* Therapeutic index of 641<br />
<br />
== Intoxication Treatment ==<br />
* Supportive Care<br />
* Pt's placed in a calm, quiet environment<br />
* Monitor Vitals<br />
* If worsening vitals or agitation treat with Benzodiazepines<br />
* Can be discharged if symptoms abate and vitals normalize</div>
Lwmerwin