View source for Cyclophosphamide

==Administration==
*Type: Antineoplastic/immune modulating agent
*Dosage Forms:
*Routes of Administration: IV, oral
*Common Trade Names: 

==Adult Dosing==
*Vasculitis: 2 mg/kg PO daily '''OR''' 15mg/kg IV q2 weeks x3 then q3 weeks. Adjust dose to avoid severe leukopenia
*Lupus nephritis: 1g/m(2) IV monthly
*Neuropsychiatric lupus:  0.75 g/m(2) IV q1mo x 1 year, then q3mo x 3 years
*Oncologic uses: Typically much higher doses (e.g. 40 to 50 mg/kg IV over several days)

==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: D
*[[Lactation risk categories|Lactation risk]]: Infant risk has been demonstrated
*Renal dosing:
*Hepatic dosing: 

==Contraindications==
*Allergy to class/drug
*Urinary outflow obstruction

==Adverse Reactions==
===Serious===
*Malignancy: leukemia, bladder, renal pelvis, dermis, angiosarcoma
*Pericardial effusion, cardiac tamponade
*Cardiac toxicity, CHF
*SJS/TEN
*Interstitial pneumonia, pulmonary fibrosis
*Infection/sepsis
*Bladder fibrosis/contracture, hemorrhagic cystitis, 
*Azoospermia
===Common===
*Alopecia, skin pigmentation changes, rash, nail damage
*Nausea/vomiting, diarrhea, anorexia
*Leukopenia, neutropenia
*Amenorrhea

==Pharmacology==
*Half-life: 3-12h
*Metabolism: Hepatic
*Excretion: Renal

==Mechanism of Action==
*Alkylating agent, cross-links strands of DNA and RNA, inhibits protein synthesis

==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]