View source for Fenoldopam

==Administration==
*Type: [[Antihypertensive]], Dopamine agonist
*Dosage Forms: 10mg/mL (1 mL), 20mg/2 mL (2 mL)
*Routes of Administration: Intravenous
*Common Trade Names: Corlopam

==Adult Dosing==
*Severe hypertension: Initial 0.01 to 0.3 mcg/kg/minute, increase incrementally 0.05 to 0.1 mcg/kg/minute q 15 minute until target blood pressure is reached (maximum dose recorded in the study was 1.6 mcg/kg/minute), limit for up to 48-hour use.

==Pediatric Dosing==
*Severe hypertension: Initial 0.2 mcg/kg/minute; increase incrementally 0.3 to 0.5 mcg/kg/minute q 20 to 30 minutes (maximum 0.8 mcg/kg/minute), limit for 4-hour use

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: B
*[[Lactation risk categories|Lactation risk]]: Not defined
===Renal Dosing===
*Adult: Not defined
*Pediatric: Not defined
===Hepatic Dosing===
*Adult: Not defined
*Pediatric: Not defined

==Contraindications==
*Allergy to class/drug
*Caution if:
**sulfite hypersensitivity
**asthma
**glaucoma, intraocular HTN, elevated ICP
**acute stroke
**cardiac disease, arrythmias
**hypokalemia
**active bleeding
**portal hypertension

==Adverse Reactions==
===Serious===
*hypotension, severe
*tachycardia
*CHF, MI, angina
*hypokalemia
*leukocytosis

===Common===
*headache, dizziness
*flushing, diaphoresis, anxiety, tachycardia
*hypotension
*ST-T wave changes
*nausea/vomiting, abdominal pain, diarrhea, constipation
*injection site reaction
*back pain
*nasal congestion
*IOP elevation

==Pharmacology==
*Half-life: 5 min
*Metabolism: Liver extensively; CYP450
*Excretion: urine 90%, feces 10%

==Mechanism of Action==
*stimulates dopamine D1-like and α-2 adrenergic receptors

==Comments==

==See Also==
*[[Hypertension]]

==References==
<references/>
[[Category:Pharmacology]]