View source for Aripiprazole

==Administration==
*Type: Atypical [[antipsychotic]]
*Dosage Forms: tablet, oral disintegrating tablet, oral solution, extended-release injectable IM suspension
*Routes of Administration: PO, IM depot
*Common Trade Names: Abilify, Maintena, Aristada

==Adult Dosing==
*2-30 mg PO daily
==Pediatric Dosing==
*> 6yo: 2-30 mg PO daily (slower titration up)
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Concomitant use of CYP3A4 or CYP2D6 inhibitors: reduce dose
*Concomitant use of CYP3A4 inducers: increase dose
*Renal dosing: no adjustment
*Hepatic dosing: no adjustment

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Cardiac arrest, cardiac failure, prolonged QT, MI
*Neuroleptic malignant syndrome, hyperthermia, rhabdomyolysis
*Seizure, stroke
*Tardive dyskinesia
*Agranulocytosis, leukopenia
*Angioedema
*Pancreatitis
*DKA
*Suicidal behavior
===Common===
*Somnolence, dizziness, akathisia, anxiety, insomnia, headache
*Extrapyramidal symptoms, tremor
*Nausea, vomiting, constipation
*Weight gain

==Pharmacology==
*Half-life: ~75 hours
*Metabolism:  Hepatic via CYP2D6 and CYP3A4
*Excretion: Mostly fecal

==Mechanism of Action==
*Not well understood. D2 and HT2A antagonist, D3 and 5HT1A partial agonist

==Comments==

==See Also==
*[[Antipsychotics]]
==References==
<references/>
[[Category:Pharmacology]] [[Category:Psychiatry]]