View source for Aplastic crisis

==Background==
*Also called Reticulocytopenia: abnormal decrease of reticulocytes in the body
*Clinically common in [[Sickle cell crisis]] and [[Hereditary Spherocytosis (HS)]]

==Clinical Presentation==
*[[Sickle cell crisis]]
*[[Anemia]]
*Increased fatigue, pallor
*Activity intolerance
*Shortness of breath

==Causes==
*[[Erythema Infectiosum (Fifth disease)]]
**Invades and destroys red blood cell precursors and halts the red cell production
*EBV
*Strep infection
*Use of hydroxyurea

==Labs==
*CBC w/ retic count
**Decrease from baseline H/H
**Precipitous drop in reticulocyte count (or lack of response)

==Management==
*Admit
*Transfusion using extended antigen-typed, leuko-depleted pRBCs

==Recovery Phase==
*Typically in 1-2 weeks
*Often marked by hyperbilirubinemia, and called a “hyperhemolytic” phase<ref>http://www.ihtc.org/medical-professionals/blood-disorders/sickle-cell-disease/aplastic-crisis-intervention/</ref>

==Also See==
*[[Erythema Infectiosum (Fifth disease)]]
*[[Hereditary Spherocytosis (HS)]]
*[[Sickle cell crisis]]

==Source==
*Janz TJ, Hamilton GC: Anemia, Polycythemia, and White Blood Cell Disorders, in Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen’s Emergency Medicine: Concepts and Clinical Practice, ed 7. St. Louis, Mosby, Inc., 2010, (Ch) 119:p 1568-1574.
*http://www.ihtc.org/medical-professionals/blood-disorders/sickle-cell-disease/aplastic-crisis-intervention/ - last accessed 1/6/15

[[Category:ID]]
[[Category:Heme/Onc]]