View source for Cefaloglycin

==General==
*Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: capsule
*Dosage Strengths: 250mg, 500mg
*Routes of Administration: PO
*Common Trade Names: Kefoglycin

==Adult Dosing==
===General===
*Mild-Mod: 250mg PO q6h
*Severe: 500mg PO q6h
*Max: 4g/day

===[[UTI]], Uncomplicated===
*250-500mg PO q6h

==Pediatric Dosing==
===General (>1 Month)===
*25-50mg/kg/day PO divided q6h
*Max: 4g/day

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use caution
*Renal
**Adult
***CrCl <10 or significant impairment: Modify interval (data limited on specific adjustments, often avoided in severe failure due to ineffective urine concentrations)
*Hepatic
**Not defined

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]] Associated Diarrhea
*Neutropenia
*Nephrotoxicity (rare)

===Common===
*[[Diarrhea]] (Higher incidence compared to other cephalosporins)
*[[Nausea and Vomiting]]
*[[Abdominal Pain]]
*[[Rash]]
*Urticaria
*Dyspepsia
*Glossitis

==Pharmacology==
*Half-life: 1.5h
*Metabolism: Limited hepatic metabolism; deacetylated to desacetylcephaloglycin
*Excretion: Urine (excreted unchanged)
*Mechanism of Action: Bactericidal; binds to penicillin binding proteins and inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||X1
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||I
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]