View source for Cefazaflur

==General==
*Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg, 1g
*Routes of Administration: IV, IM
*Common Trade Names: Celit

==Adult Dosing==
===General===
*Mild-Moderate: 500mg-1g IM/IV q6-8h
*Severe: 1g-2g IM/IV q6h
*Max: 6g/day

===[[UTI]], Uncomplicated===
*500mg IM/IV q8h

===Surgical Prophylaxis===
*1g IM/IV x1 (30-60 min before procedure)

==Pediatric Dosing==
===General (>3 Months)===
*Mild-Moderate: 25-50 mg/kg/day IM/IV divided q6-8h
*Severe: 50-100 mg/kg/day IM/IV divided q6h
*Max: 4g/day (should not exceed adult dose)

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl 50-80: give q8h
***CrCl 25-50: give q12h
***CrCl <10: give q24h
***Hemodialysis: Give dose after dialysis
***Peritoneal dialysis: Supplement not usually required
**Pediatric
***Renal dosing not well defined; adjust based on adult ratios
*Hepatic
**Not defined

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*Immediate hypersensitivity to Penicillins

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Neutropenia]] (prolonged use)
*[[Thrombocytopenia]]
*[[Clostridium difficile]] associated diarrhea
*Nephrotoxicity (rare, higher risk with aminoglycosides)
*[[Seizures]] (risk accumulation)

===Common===
*[[Nausea and Vomiting]]
*[[Diarrhea]]
*[[Rash]]
*Phlebitis at injection site
*Pain at injection site (IM)
*Eosinophilia
*Transaminitis

==Pharmacology==
*Half-life: 0.5 - 1h (Prolonged in renal impairment)
*Metabolism: Partially metabolized in liver
*Excretion: Urine
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||X1
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||X1
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]
*[[Cephalosporins]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]