View source for Warfarin-induced skin necrosis

==Background==
*Differing half-lives of Vitamin-K dependent coagulation factors leads to relative protein C deficiency initially→ hypercoagulability
*Onset usually in first week of starting [[warfarin]]

==Clinical Features==
[[File:Right leg affected by warfarin necrosis.png|thumb|Right leg affected by warfarin necrosis.]]
[[File:WarfarinNecrosis.png|thumb]]
*Painful, red [[rash|lesions]] over extremities, trunk, penis
*Start with erythematous macule→ edema→ central purpuric zones → necrosis

==Differential Diagnosis==
{{Necrotizing Rashes DDX}}

==Evaluation==
*Clinical diagnosis

==Management==
*Stop warfarin
*[[Low molecular weight heparin]] or unfractionated [[heparin]]

==Disposition==

==See Also==

==External Links==

==References==
<references/>

[[Category:Heme/Onc]]
[[Category:Dermatology]]