Aluminum toxicity - Revision history

Cole Ettingoff: /* Disposition */

2025-05-05T16:08:55Z

Disposition

← Older revision		Revision as of 16:08, 5 May 2025
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	==Disposition==		==Disposition==
			=== Admission Criteria ===

			Symptomatic patients (e.g., altered mental status, seizures, severe bone pain).

			Known or suspected aluminum overload in the setting of renal failure.

			Patients requiring chelation or dialysis should be admitted for monitoring and treatment.

			=== Outpatient Management ===

			Asymptomatic patients with mild elevations (e.g., <50 µg/L) and no risk factors (e.g., normal renal function) may be monitored closely with repeat labs and exposure cessation.

			=== Follow-up ===

			Patients with chronic exposure or prior toxicity should be referred for occupational medicine or toxicology evaluation.

			Renal patients should have their dialysis fluids and medications reviewed for aluminum content.

			Bone health monitoring may be warranted in those with chronic exposure or symptoms suggestive of osteomalacia or osteoporosis.

	==See Also==		==See Also==

Cole Ettingoff: /* Management */

2025-05-05T16:07:57Z

Management

← Older revision		Revision as of 16:07, 5 May 2025
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	==Management==		==Management==
	*Stop exposure		*Stop exposure
	*Chelation with [[deferoxamine~~]] for severe~~ or ~~symptomatic systemic toxicity~~		*Supportive care is the cornerstone of treatment, particularly in mild cases. This includes respiratory support (e.g., bronchodilators for bronchospasm) and symptomatic treatment of neurological or musculoskeletal manifestations.
			*Chelation therapy:
			**Deferoxamine is the chelator of choice for aluminum toxicity. It binds free aluminum, forming a water-soluble complex (aluminoxamine) excreted by the kidneys.
			**Indications include: symptomatic patients with serum aluminum >50 µg/L, or any patient with encephalopathy, bone disease, or anemia attributed to aluminum.
			**Use with caution in patients with renal impairment, as deferoxamine-aluminum complexes require adequate renal clearance; dialysis may be needed to remove the chelated complex.
			*Dialysis: Consider hemodialysis in patients with renal failure and aluminum overload, particularly if encephalopathy is present or if chelation is being performed.
			*Avoidance of aluminum-containing medications, including phosphate binders, IV fluids, or antacids, is important during and after treatment.

	==Disposition==		==Disposition==

Elcatracho: /* Differential Diagnosis */

2021-03-08T21:28:31Z

Differential Diagnosis

← Older revision		Revision as of 21:28, 8 March 2021
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	==Differential Diagnosis==		==Differential Diagnosis==
	{{Heavy ~~metal toxicity~~}}		{{Heavy metals list}}

	==Evaluation==		==Evaluation==

Elcatracho: /* Differential Diagnosis */

2021-03-08T21:26:36Z

Differential Diagnosis

← Older revision		Revision as of 21:26, 8 March 2021
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	==Differential Diagnosis==		==Differential Diagnosis==
	{{~~Template:~~ Heavy metal ~~Toxicity~~}}		{{Heavy metal toxicity}}

	==Evaluation==		==Evaluation==

Elcatracho: /* Systemic aluminum toxicity */

2021-03-08T21:25:25Z

Systemic aluminum toxicity

← Older revision		Revision as of 21:25, 8 March 2021
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	*Seziures		*Seziures
	*Acute or subacute [[altered mental status]]		*Acute or subacute [[altered mental status]]

			==Differential Diagnosis==
			{{Template: Heavy metal Toxicity}}

	==Evaluation==		==Evaluation==

Elcatracho: /* See Also */

2021-03-08T21:22:31Z

Elcatracho: /* Systemic aluminum toxicity= */

2021-03-08T21:22:10Z

Systemic aluminum toxicity=

← Older revision		Revision as of 21:22, 8 March 2021
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	*Physical irritant, nuisance particulate		*Physical irritant, nuisance particulate

	==Systemic aluminum toxicity===		==Systemic aluminum toxicity==
	*Usually in renal patients on long-term dialysis with aluminum-containing dialysate		*Usually in renal patients on long-term dialysis with aluminum-containing dialysate
	*Rarely acute		*Rarely acute

ClaireLewis at 15:16, 22 August 2017

2017-08-22T15:16:43Z

← Older revision		Revision as of 15:16, 22 August 2017
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	==Aluminum oxide==		==Aluminum oxide==
	*Physical irritant, nuisance particulate		*Physical irritant, nuisance particulate

			==Systemic aluminum toxicity===
			*Usually in renal patients on long-term dialysis with aluminum-containing dialysate
			*Rarely acute
			*Muscle weakness (especially proximal)
			*Premature osteoporosis, bone pain, multiple fractures
			*Seziures
			*Acute or subacute [[altered mental status]]

	==Evaluation==		==Evaluation==
			*Aluminum level > 50 µg/L (mcg/dL) suggests aluminum overload and possible toxicity
			**Symptomatic patients with levels 20-50 may also need treatment

	==Management==		==Management==
			*Stop exposure
			*Chelation with [[deferoxamine]] for severe or symptomatic systemic toxicity

	==Disposition==		==Disposition==

Zipdoc at 00:28, 13 April 2017

2017-04-13T00:28:24Z

← Older revision		Revision as of 00:28, 13 April 2017
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	==References==		==References==
	<references/>		<references/>

			[[Category:Toxicology]]

Bisakson: Created page with "==Aluminum Metal== Dusts cause respiratory tract and eye irritation Acute exposures can cause bronchoconstriction and asthma-like response *Chronic exposure can lead to pulm..."

2017-04-04T18:17:01Z

Created page with "==Aluminum Metal== *Dusts cause respiratory tract and eye irritation *Acute exposures can cause bronchoconstriction and asthma-like response *Chronic exposure can lead to pulm..."

New page

==Aluminum Metal==
*Dusts cause respiratory tract and eye irritation
*Acute exposures can cause bronchoconstriction and asthma-like response
*Chronic exposure can lead to pulmonary fibrosis
*Increased incidence of cancer

==Aluminum phosphide==
*Used as a fumigant
*Contact with moisture produces phosphine gas
*Respiratory tract irritant

==Aluminum oxide==
*Physical irritant, nuisance particulate

==Evaluation==

==Management==

==Disposition==

==See Also==

==External Links==

==References==
<references/>

← Older revision		Revision as of 21:22, 8 March 2021
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	==See Also==		==See Also==
			*[[Toxicology (main)]]

	==External Links==		==External Links==

Aluminum toxicity - Revision history

Cole Ettingoff: /* Disposition */

Cole Ettingoff: /* Management */

Elcatracho: /* Differential Diagnosis */

Elcatracho: /* Differential Diagnosis */

Elcatracho: /* Systemic aluminum toxicity */

Elcatracho: /* See Also */

Elcatracho: /* Systemic aluminum toxicity= */

ClaireLewis at 15:16, 22 August 2017

Zipdoc at 00:28, 13 April 2017

Bisakson: Created page with "==Aluminum Metal== *Dusts cause respiratory tract and eye irritation *Acute exposures can cause bronchoconstriction and asthma-like response *Chronic exposure can lead to pulm..."

Bisakson: Created page with "==Aluminum Metal== Dusts cause respiratory tract and eye irritation Acute exposures can cause bronchoconstriction and asthma-like response *Chronic exposure can lead to pulm..."