Behçet's disease - Revision history

Rossdonaldson1 at 17:46, 2 August 2023

2023-08-02T17:46:29Z

← Older revision		Revision as of 17:46, 2 August 2023
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	*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement		*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
	*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations		*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

			{{Primary Vasculitis DDX}}

	==Clinical Features==		==Clinical Features==

ClaireLewis: /* Management */

2019-10-17T23:32:57Z

Management

← Older revision		Revision as of 23:32, 17 October 2019
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	*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate		*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate
	*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]		*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]
	*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral		*Ocular: [[Prednisone]] + [[azathioprine]] and rapid ophthalmologist referral
	*Cerebral [[venous sinus thrombosis]]- [[heparin]]		*Cerebral [[venous sinus thrombosis]]- [[heparin]]

ClaireLewis: /* Differential Diagnosis */

2017-08-17T07:28:32Z

Differential Diagnosis

← Older revision		Revision as of 07:28, 17 August 2017
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	==Differential Diagnosis==		==Differential Diagnosis==
	*[[HSV]]		*[[HSV]]
	*[[~~lichen~~ planus]]		*[[Lichen planus]]
	*[[~~pemphigus~~ vulgaris]]		*[[Pemphigus vulgaris]]
	*[[pemphigoid]]		*[[Bullous pemphigoid]]
	*IVD		*IVD
	*[[SJS]]		*[[SJS]]

ClaireLewis: /* Differential Diagnosis */

2017-08-17T07:27:46Z

Differential Diagnosis

← Older revision		Revision as of 07:27, 17 August 2017
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	*celiac disease		*celiac disease
	*[[SLE]]		*[[SLE]]
	*[[~~Sjogren's~~]]		*[[Sjögren Syndrome]]
	*[[MS]]		*[[MS]]
	*[[Sarcoidosis]]		*[[Sarcoidosis]]
	*[[Syphilis]]		*[[Syphilis]]
	*[[TB]]		*[[TB]]
	*~~malignancy~~		*Malignancy
	*[[Reactive arthritis]]		*[[Reactive arthritis]]
	*[[HIV]]		*[[HIV]]
	*Other [[vasculitis ~~syndromes~~]]		*Other [[vasculitis]] syndromes

	==Evaluation==		==Evaluation==

ClaireLewis: Created page with "==Background== thumb| Chronic small-vessel vasculitis Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS i..."

2017-08-17T04:46:22Z

Created page with "==Background== thumb| *Chronic small-vessel vasculitis *Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS i..."

New page

==Background==
[[File:Behcet's.png|thumb|]]
*Chronic small-vessel [[vasculitis]]
*Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS involvement
*Aphthous oral ulcers + ≥ 2 of following: Genital aphthae, cutaneous lesions, and neurological, oral or rheumatologic manifestations

==Clinical Features==
*Age 20-30s most commonly
*More common in Turkey, Japan, Middle East
*Triad: Recurrent oral aphthous ulcers, genital ulcers, and [[uveitis]]
*Classically painful ulcer with necrotic center and red rim
*Skin: Subcutaneous nodules, pyoderma gangrenosum, cutaneous thrombophlebitis, pustular acne-like folliculitis
*Ocular: [[Uveitis]], iritis, [[optic neuritis]], [[vision loss]], hypopyon
*Neurologic: Brainstem and corticospinal tract syndromes, aseptic [[meningoencephalitis]], [[increased ICP]], [[cerebral sinus thrombosis]], optic nerve ischemia
*GI: Ulcers, obstruction, ileocecal perforation
*Inflammatory oligo[[arthritis]]
*Vasculopathy: Aneurysm, [[vasculitis]], superficial [[thrombophlebitis]], thrombosis
*Cardiac: [[Myocarditis]], [[endocarditis]], [[pericarditis]]
*Renal: [[Glomerulonephritis]], amyloidosis
*Pulmonary: [[Pleural effusions]], [[pulmonary hypertension]], pulmonary aneurysm

==Differential Diagnosis==
*[[HSV]]
*[[lichen planus]]
*[[pemphigus vulgaris]]
*[[pemphigoid]]
*IVD
*[[SJS]]
*celiac disease
*[[SLE]]
*[[Sjogren's]]
*[[MS]]
*[[Sarcoidosis]]
*[[Syphilis]]
*[[TB]]
*malignancy
*[[Reactive arthritis]]
*[[HIV]]
*Other [[vasculitis syndromes]]

==Evaluation==
*Clinical diagnosis
*ESR/CRP elevated

===Classification===
*International Study Group Criteria
*Recurrent oral aphthae (at least 3 times in 1 year) + 2 of the following in absence of other systemic diseases:
**Recurrent genital aphthae
**Eye lesions
**Skin lesions
**A positive pathery test

==Management==
*Rheumatology consult +/- multidisciplinary consults
*Oral and genital ulcers: [[Topical steroids]]
*Severe mucocutaneous disease: [[Prednisone]] 1mg/kg, low-dose thalidomide, or methotrexate
*Systemic disease: Steroid +/- [[cyclophosphamide]] or [[azathioprine]]
*Ocular: Prednisone + azathioprine and rapid ophthalmologist referral
*Cerebral [[venous sinus thrombosis]]- [[heparin]]

==References==
<references/>
*Rosen's Emergency Medicine 8th edition. 2013. Chapter: Erythematosus and the Vasculitides. p1540.
*Smith EL, et al. Clinical manifestations and diagnosis of Behcet's disease. In: Post T, ed. UpToDate. Waltham, Mass.: UpToDate; 2014. www.uptodate.com. Accessed December 22, 2014.
*Alnaimat FA, et al. (2014, Dec 16). Behcet Disease. eMedicine. Retrieved 12/22/2014 from http://emedicine.medscape.com/article/329099-overview

[[Category:Rheumatology]]

Behçet's disease - Revision history

Rossdonaldson1 at 17:46, 2 August 2023

ClaireLewis: /* Management */

ClaireLewis: /* Differential Diagnosis */

ClaireLewis: /* Differential Diagnosis */

ClaireLewis: Created page with "==Background== thumb| *Chronic small-vessel vasculitis *Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS i..."

ClaireLewis: Created page with "==Background== thumb| Chronic small-vessel vasculitis Mucocutaneous, ocular, cardiovascular, renal, GI, pulmonary, urologic, musculoskeletal, CNS i..."