Cefaclor - Revision history

Ostermayer at 16:10, 18 July 2025

2025-07-18T16:10:44Z

← Older revision		Revision as of 16:10, 18 July 2025
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	==General==		==General==
	*Type: ~~Second~~ generation [[Is DrugClass::cephalosporin]]		*Type: [[Is Generation::2nd generation]] [[Is DrugClass::cephalosporin]]
	*Dosage Forms: capsule, tablet, oral suspension		*Dosage Forms: capsule, tablet, oral suspension
	*Dosage Strengths: capsule: 250mg, 500mg; tablet 500mg; oral suspension: 125mg/5mL, 250mg/5mL, 375mg/5mL		*Dosage Strengths: capsule: 250mg, 500mg; tablet 500mg; oral suspension: 125mg/5mL, 250mg/5mL, 375mg/5mL

Ostermayer at 14:51, 18 July 2025

2025-07-18T14:51:06Z

← Older revision		Revision as of 14:51, 18 July 2025
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	==General==		==General==
	*Type: Second generation [[cephalosporin]]		*Type: Second generation [[Is DrugClass::cephalosporin]]
	*Dosage Forms: capsule, tablet, oral suspension		*Dosage Forms: capsule, tablet, oral suspension
	*Dosage Strengths: capsule: 250mg, 500mg; tablet 500mg; oral suspension: 125mg/5mL, 250mg/5mL, 375mg/5mL		*Dosage Strengths: capsule: 250mg, 500mg; tablet 500mg; oral suspension: 125mg/5mL, 250mg/5mL, 375mg/5mL

ClaireLewis at 21:47, 19 September 2019

2019-09-19T21:47:39Z

← Older revision		Revision as of 21:47, 19 September 2019
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	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]] [[Category:ID]]

Fletc151: /* References */

2019-06-13T13:29:31Z

References

← Older revision		Revision as of 13:29, 13 June 2019
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	==References==		==References==
			*Ahlfors CE. Benzyl alcohol, kernicterus, and unbound bilirubin. J Pediatr. 2001;139(2):317-319. [PubMed 11487763]
			*American Thoracic Society, “Guidelines for the Initial Management of Adults With Community-Acquired Pneumonia: Diagnosis, Assessment of Severity, and Initial Antimicrobial Therapy,” Am Rev Respir Dis, 1993, 148(5):1418-26. [PubMed 8239186]
			*Aronoff GR, Bennett WM, Berns JS, et al, Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children, 5th ed. Philadelphia, PA: American College of Physicians; 2007, p 61, 153.
			*Boguniewicz M and Leung DYM, “Hypersensitivity Reactions to Antibiotics Commonly Used in Children,” Pediatr Infect Dis J, 1995, 14(3):221-31. [PubMed 7761188]
			*Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: a literature review. J Emerg Med. 2012; 42(5):612-620. [PubMed 21742459]
			*Cefaclor Capsules [prescribing information]. Eatontown, NJ: West-Ward Pharmaceuticals; July 2015.
			*Cefaclor Extended-Release Tablets [prescribing information]. North Wales, PA: Teva Pharmaceuticals; December 2014.

	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Humanguy: /* Pharmacology */ edited metabolism

2017-10-12T00:38:58Z

Pharmacology: edited metabolism

← Older revision		Revision as of 00:38, 12 October 2017
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	==Pharmacology==		==Pharmacology==
	*Half-life: 35-54 min; 2-3hr in ERSD		*Half-life: 35-54 min; 2-3hr in ERSD
	*Metabolism: ~~Other~~		*Metabolism: Partial, hepatic
	*Excretion: Urine primarily (60-85% unchanged)		*Excretion: Urine primarily (60-85% unchanged)
	*Mechanism of Action: Inhibits cell wall mucopeptide synthesis; bactericidal		*Mechanism of Action: Inhibits cell wall mucopeptide synthesis; bactericidal

Humanguy: edited dosage forms, strengths, routes of administration, trade names

2017-10-12T00:38:09Z

edited dosage forms, strengths, routes of administration, trade names

← Older revision		Revision as of 00:38, 12 October 2017
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	==General==		==General==
	*Type: Second generation [[cephalosporin]]		*Type: Second generation [[cephalosporin]]
	*Dosage Forms: ~~Capsule~~ 250mg, 500mg; ~~Tablet~~ 500mg; ~~Suspension~~ 125mg/5mL, 250mg/5mL, 375mg/5mL		*Dosage Forms: capsule, tablet, oral suspension
	*Common Trade Names: Ceclor		*Dosage Strengths: capsule: 250mg, 500mg; tablet 500mg; oral suspension: 125mg/5mL, 250mg/5mL, 375mg/5mL
			*Routes of Administration: PO
			*Common Trade Names: Ceclor, Raniclor

	==Adult Dosing==		==Adult Dosing==

Jonwarren at 20:58, 5 September 2017

2017-09-05T20:58:57Z

← Older revision		Revision as of 20:58, 5 September 2017
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	==General==		==General==
	*Type: Second generation [[cephalosporin]]		*Type: Second generation [[cephalosporin]]
	*Dosage Forms:		*Dosage Forms: Capsule 250mg, 500mg; Tablet 500mg; Suspension 125mg/5mL, 250mg/5mL, 375mg/5mL
	*Common Trade Names: Ceclor		*Common Trade Names: Ceclor

	==Adult Dosing==		==Adult Dosing==
			===[[Infection]], bacterial===
			*Immediate-release:
			**250-500 mg PO q8h
			***Max: 2 g/day
			*Extended-release:
			**500 mg ER PO q12h
			***Max 2 g/day
	==Pediatric Dosing==		==Pediatric Dosing==
			===[[Infection]], bacterial===
			*1+ mo
			**20-40 mg/kg/day PO divided 18-12h
			***Max: 1 g/day

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: B
	*Lactation:		*Lactation: May use while breastfeeding

	*Renal Dosing		*Renal Dosing
	**Adult		**Adult:
			***No adjustment
			***HD: Give dose after dialysis
			***PD: No supplement
	**Pediatric		**Pediatric
			***CrCl <10: Decrease dose 50%
			***HD: Give dose after dialysis
			**PD: No supplement
	*Hepatic Dosing		*Hepatic Dosing
	**Adult		**Adult:
			***Not defined
	**Pediatric		**Pediatric
			***Not defined

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Caution:
			**Hypersensitivity to [[penicillin]]
			**Renal impairment
			**Concurrent nephrotoxic agent
			**[[Seizure]] disorder
			**Recent abx-associated colitis history

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*[[Anaphylaxis]]
			*[[Thrombocytopenia]]
			*Serum-sickness like reaction
			*[[Seizure]]
			*Nephrotoxicity
			*[[Neutropenia]]
			*[[Anemia]], hemolytic
			*Exfoliative dermatitis
			*[[Stevens-Johnson Syndrome]]
			*Superinfection
			*C. difficile associated [[diarrhea]]
			*Cholestatic [[jaundice]]

	===Common===		===Common===
			*[[Diarrhea]], [[nausea]], [[vomiting]]
			*[[Vaginitis]]
			*[[Pruritus]], [[rash]], [[urticaria]]
			*LFT elevation
			*Eosinophilia

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 35-54 min; 2-3hr in ERSD
	*Metabolism:		*Metabolism: Other
	*Excretion:		*Excretion: Urine primarily (60-85% unchanged)
	*Mechanism of Action:		*Mechanism of Action: Inhibits cell wall mucopeptide synthesis; bactericidal

	==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==		==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Mholtz at 23:05, 30 August 2017

2017-08-30T23:05:59Z

← Older revision		Revision as of 23:05, 30 August 2017
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	*Type: Second generation [[cephalosporin]]		*Type: Second generation [[cephalosporin]]
	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names:		*Common Trade Names: Ceclor

	==Adult Dosing==		==Adult Dosing==

Neil.m.young: Text replacement - "==Source== " to "==References== "

2016-06-25T14:53:26Z

Text replacement - "==Source== <references/>" to "==References== <references/>"

← Older revision		Revision as of 14:53, 25 June 2016
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	*[[Antibiotics (Main)]]		*[[Antibiotics (Main)]]

	==~~Source~~==		==References==
	<references/>		<references/>

	[[Category:Pharmacology]]		[[Category:Pharmacology]]

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:53:45Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:53, 22 March 2016
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	<references/>		<references/>

	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]