Ostermayer: Created page with "==General== Type: Is Generation::1st generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 500mg; 1g, 2g, 4g, 20g Routes of Administration: IV, IM Common Trade Names: Cefadyl ==Adult Dosing== ===General=== Mild-Moderate: 500mg-1g IM/IV q4-6h Severe: 1g-2g IM/IV q4h Max: 12g/day ===Perioperative Prophylaxis=== 1-2g IM/IV x1 (30-60 min before procedure) Intraoperative: 1-2g may be repeated during lengthy surgeries *..."

2026-01-27T17:30:08Z

Created page with "==General== *Type: Is Generation::1st generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 500mg; 1g, 2g, 4g, 20g *Routes of Administration: IV, IM *Common Trade Names: Cefadyl ==Adult Dosing== ===General=== *Mild-Moderate: 500mg-1g IM/IV q4-6h *Severe: 1g-2g IM/IV q4h *Max: 12g/day ===Perioperative Prophylaxis=== *1-2g IM/IV x1 (30-60 min before procedure) *Intraoperative: 1-2g may be repeated during lengthy surgeries *..."

New page

==General==
*Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg; 1g, 2g, 4g, 20g
*Routes of Administration: IV, IM
*Common Trade Names: Cefadyl

==Adult Dosing==
===General===
*Mild-Moderate: 500mg-1g IM/IV q4-6h
*Severe: 1g-2g IM/IV q4h
*Max: 12g/day

===Perioperative Prophylaxis===
*1-2g IM/IV x1 (30-60 min before procedure)
*Intraoperative: 1-2g may be repeated during lengthy surgeries
*Postoperative: 1-2g q6h for 24 hours

==Pediatric Dosing==
===General (>3 Months)===
*40-80mg/kg/day IM/IV divided q6h
*Max: 12g/day (should not exceed adult dose)

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl > 50: usual dose
***CrCl 10-50: 500mg-1g q6-8h
***CrCl <10: 500mg-1g q12h
***Hemodialysis: Give dose before dialysis and boost with 0.5-1g after each session
**Pediatric
***Renal dosing not well defined; adjust based on adult ratios or avoid
*Hepatic
**Not defined

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*History of anaphylactic reaction to Penicillins

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Neutropenia]] (prolonged use)
*[[Thrombocytopenia]]
*[[Clostridium difficile]] associated diarrhea
*Nephrotoxicity (rare, higher risk with aminoglycosides)
*[[Seizures]] (high doses in renal failure)

===Common===
*[[Nausea and Vomiting]]
*[[Diarrhea]]
*[[Rash]]
*Phlebitis at injection site
*Pain at injection site (IM)
*Eosinophilia
*Transaminitis

==Pharmacology==
*Half-life: 0.6-0.8h (Prolonged in renal impairment)
*Metabolism: Partially metabolized in liver and blood to desacetylcefapirin
*Excretion: Urine (approx 70% as unchanged drug)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||X1
|-
| ||[[N. meningitidis]]||X1
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||X1
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]
*[[Cefazolin]]

==References==
<references/>
*Epocrates

[[Category:Pharmacology]] [[Category:ID]]

Cefapirin - Revision history