Ostermayer: Created page with "==General== Type: Is Generation::4th generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 500mg, 1g Routes of Administration: IV Common Trade Names: Firstcin ==Adult Dosing== ===General=== Standard: 500mg - 1g IV q12h Moderate-Severe: 1g IV q8h OR 2g IV q12h Life Threatening: 2g IV q8h Max: 4-6g/day ===Pneumonia / Respiratory Tract Infections=== 1g IV q12h *Effective against Pseudomonas aeruginosa ===U..."

2026-01-28T20:14:49Z

Created page with "==General== *Type: Is Generation::4th generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 500mg, 1g *Routes of Administration: IV *Common Trade Names: Firstcin ==Adult Dosing== ===General=== *Standard: 500mg - 1g IV q12h *Moderate-Severe: 1g IV q8h OR 2g IV q12h *Life Threatening: 2g IV q8h *Max: 4-6g/day ===Pneumonia / Respiratory Tract Infections=== *1g IV q12h *Effective against Pseudomonas aeruginosa ===U..."

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==General==
*Type: [[Is Generation::4th generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg, 1g
*Routes of Administration: IV
*Common Trade Names: Firstcin

==Adult Dosing==
===General===
*Standard: 500mg - 1g IV q12h
*Moderate-Severe: 1g IV q8h OR 2g IV q12h
*Life Threatening: 2g IV q8h
*Max: 4-6g/day

===[[Pneumonia]] / Respiratory Tract Infections===
*1g IV q12h
*Effective against [[Pseudomonas aeruginosa]]

===[[UTI]], Complicated and Uncomplicated===
*0.5-1g IV q12h

===[[Sepsis]]===
*1-2g IV q8-12h

===[[Meningitis]]===
*2g IV q8h

==Pediatric Dosing==
===General===
*40-80 mg/kg/day IV divided q6-8h or q12h
*Severe / Meningitis: Up to 100-120 mg/kg/day IV divided q6-8h
*Max: Adult daily maximum (typically 4g/day)

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl 60-100: No adjustment
***CrCl 30-60: 0.5-1g q12h
***CrCl 10-29: 0.5-1g q24h
***CrCl <10: 0.5g q24h
***Hemodialysis: Administer 0.5-1g supplement after dialysis
**Pediatric
***Adjust based on adult GFR guidelines (extend interval)
*Hepatic
**No adjustment usually necessary

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*History of anaphylactic shock to Penicillin

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*[[Seizures]] / Encephalopathy (especially in renal failure without dose adjustment)
*Neurotoxicity
*Agranulocytosis

===Common===
*[[Diarrhea]]
*[[Rash]]
*[[Nausea and Vomiting]]
*[[Abdominal Pain]]
*Phlebitis
*Transaminitis (Elevated AST/ALT)
*Eosinophilia

==Pharmacology==
*Half-life: 1.5 - 2h
*Metabolism: Minimally metabolized
*Excretion: Urine (largely unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Spectrum Note: A 4th generation agent with a quaternary ammonium group, allowing rapid penetration into Gram-negative bacteria and high stability against AmpC beta-lactamases.

==[[Antibiotic Sensitivities]]<ref>Japanese Journal of Antibiotics</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||I
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC pos||'''S'''
|-
| ||[[Serratia]] sp||'''S'''
|-
| ||Serratia marcescens||'''S'''
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||'''S'''
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||'''S'''
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||I
|-
| ||[[Pseudomonas aeruginosa]]||'''[[Has Antipseudomonal::S]]'''
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefozopran - Revision history