Ostermayer: Created page with "==General== Type: Is Generation::4th generation Is DrugClass::Cephalosporin Status: Veterinary Use Only (Not approved for human use) Dosage Forms: Suspension for injection Dosage Strengths: 2.5% (25mg/mL) Routes of Administration: IM, IV (varies by animal species) Common Trade Names: Cobactan, Cefq ==Adult Dosing== ===Human Use=== '''Not indicated for human use.''' There are no established dosing guidelines for humans. ===Veterinary Use (Cattle)===..."

2026-01-28T20:19:33Z

Created page with "==General== *Type: Is Generation::4th generation Is DrugClass::Cephalosporin *Status: **Veterinary Use Only** (Not approved for human use) *Dosage Forms: Suspension for injection *Dosage Strengths: 2.5% (25mg/mL) *Routes of Administration: IM, IV (varies by animal species) *Common Trade Names: Cobactan, Cefq ==Adult Dosing== ===Human Use=== *'''Not indicated for human use.''' *There are no established dosing guidelines for humans. ===Veterinary Use (Cattle)===..."

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==General==
*Type: [[Is Generation::4th generation]] [[Is DrugClass::Cephalosporin]]
*Status: **Veterinary Use Only** (Not approved for human use)
*Dosage Forms: Suspension for injection
*Dosage Strengths: 2.5% (25mg/mL)
*Routes of Administration: IM, IV (varies by animal species)
*Common Trade Names: Cobactan, Cefq

==Adult Dosing==
===Human Use===
*'''Not indicated for human use.'''
*There are no established dosing guidelines for humans.

===Veterinary Use (Cattle)===
*Respiratory disease/Mastitis: 1mg/kg IM q24h
*Max: 5 days

===Veterinary Use (Swine)===
*Respiratory disease/MMA Syndrome: 2mg/kg IM q24h
*Max: 5 days

===Veterinary Use (Horses)===
*1mg/kg IV/IM q24h

==Pediatric Dosing==
===General===
*'''Not indicated for human use.'''

==Special Populations==
*Pregnancy: Studies in laboratory animals have not produced evidence of teratogenic effects, but human safety is not established.
*Lactation: Excreted in milk (withdrawal periods apply for food consumption animals).
*Renal
**Excreted largely unchanged via kidneys. Dosage adjustment would theoretically be required in renal failure, but guidelines exist primarily for livestock.
*Hepatic
**No extensive metabolism.

==Contraindications==
*Allergy to class/drug (Cephalosporins or Beta-lactams)

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]] (Hypersensitivity reactions)
*Superinfection
*Coagulopathy (Theoretical risk based on class)

===Common===
*Injection site swelling/reaction
*[[Diarrhea]] (in animals)
*Gastrointestinal disturbance

==Pharmacology==
*Half-life: 2-3h (varies by species)
*Metabolism: Minimally metabolized (<5%)
*Excretion: Urine (largely unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Spectrum Note: As a 4th generation cephalosporin, it possesses a zwitterionic nature facilitating rapid penetration across the outer membrane of Gram-negative bacteria and high stability against AmpC beta-lactamases.

==[[Antibiotic Sensitivities]]<ref>Veterinary Microbiology / Product Monographs</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||'''S'''
|-
| ||[[Moraxella catarrhalis]]||'''S'''
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||I
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||'''S'''
|-
| ||[[Enterobacter]] sp, AmpC pos||'''S'''
|-
| ||[[Serratia]] sp||'''S'''
|-
| ||Serratia marcescens||'''S'''
|-
| ||[[Salmonella]] sp||'''S'''
|-
| ||[[Shigella]] sp||'''S'''
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||'''S'''
|-
| ||[[Providencia sp.]]||'''S'''
|-
| ||[[Morganella sp.]]||'''S'''
|-
| ||[[Citrobacter freundii]]||'''S'''
|-
| ||[[Citrobacter diversus]]||'''S'''
|-
| ||[[Citrobacter sp.]]||'''S'''
|-
| ||[[Aeromonas sp]]||'''S'''
|-
| ||[[Acinetobacter sp.]]||I
|-
| ||[[Pseudomonas aeruginosa]]||'''[[Has Antipseudomonal::S]]'''
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||'''S'''
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||'''S'''
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||I
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||I
|-
| ||[[Fusobacterium necrophorum]]||'''S'''
|-
| ||[[Peptostreptococcus sp.]]||'''S'''
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefquinome - Revision history