Ostermayer: Created page with "==General== Type: Is Generation::3rd generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 500mg, 1g Routes of Administration: IV, IM Common Trade Names: Cefomonil, Monaspor ==Adult Dosing== ===General=== Standard: 500mg-1g IM/IV q6h Severe: 2g IM/IV q6h Max: 6-12g/day (depending on severity of infection) ===Pseudomonal Infections (Pneumonia, Soft Tissue, UTI)=== 1-2g IV q6h Often used in combination with..."

2026-01-28T19:57:07Z

Created page with "==General== *Type: Is Generation::3rd generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 500mg, 1g *Routes of Administration: IV, IM *Common Trade Names: Cefomonil, Monaspor ==Adult Dosing== ===General=== *Standard: 500mg-1g IM/IV q6h *Severe: 2g IM/IV q6h *Max: 6-12g/day (depending on severity of infection) ===Pseudomonal Infections (Pneumonia, Soft Tissue, UTI)=== *1-2g IV q6h *Often used in combination with..."

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==General==
*Type: [[Is Generation::3rd generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg, 1g
*Routes of Administration: IV, IM
*Common Trade Names: Cefomonil, Monaspor

==Adult Dosing==
===General===
*Standard: 500mg-1g IM/IV q6h
*Severe: 2g IM/IV q6h
*Max: 6-12g/day (depending on severity of infection)

===Pseudomonal Infections ([[Pneumonia]], Soft Tissue, [[UTI]])===
*1-2g IV q6h
*Often used in combination with an aminoglycoside for serious infections

==Pediatric Dosing==
===General===
*20-50mg/kg/day IM/IV divided q6h
*Severe: Up to 100mg/kg/day IM/IV divided q6h

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; use with caution
*Renal
**Adult
***CrCl 50-80: 1g q8h
***CrCl 20-49: 1g q12h
***CrCl <20: 500mg-1g q24h
***Hemodialysis: Give supplement after dialysis
**Pediatric
***Adjust based on adult GFR guidelines (extend interval)
*Hepatic
**No dosage adjustment typically required

==Contraindications==
*Allergy to class/drug (Cephalosporins)
*History of anaphylactic reaction to Penicillin

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*[[Clostridium difficile]]
*[[Seizures]] (high doses in renal impairment)
*Nephrotoxicity (rare, increased risk with aminoglycosides)
*Hemolytic Anemia

===Common===
*[[Nausea and Vomiting]]
*[[Diarrhea]]
*[[Rash]] / Pruritus
*Injection site pain/phlebitis
*Eosinophilia
*Elevated liver enzymes

==Pharmacology==
*Half-life: 1.5h (Prolonged in renal failure)
*Metabolism: Minimal
*Excretion: Urine (mostly unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
*Spectra Note: Unlike most 3rd generation cephalosporins, Cefsulodin has a very narrow spectrum, highly specific for *Pseudomonas aeruginosa* and very weak against other Gram-negatives and Gram-positives.

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||R
|-
| ||[[Strep. Pneumoniae]]||R
|-
| ||[[Viridans strep]]||R
|-
| ||Strep. anginosus gp||R
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||R
|-
| ||[[MSSA]]||R
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||R
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||R
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||R
|-
| ||[[H. influenzae]]||R
|-
| ||[[E. coli]]||R
|-
| ||[[Klebsiella]] sp||R
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||R
|-
| ||[[Salmonella]] sp||R
|-
| ||[[Shigella]] sp||R
|-
| ||[[Proteus mirabilis]]||R
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||X1
|-
| ||[[Pseudomonas aeruginosa]]||'''S'''
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||R
|-
| ||[[Brucella sp.]]||R
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||R
|-
| ||[[Haemophilus ducreyi]]||R
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||R
|-
| ||[[Mycoplasm pneumoniae]]||R
|-
| ||[[Rickettsia sp]]||R
|-
| ||[[Mycobacterium avium]]||R
|-
| Anaerobes||[[Actinomyces]]||R
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||R
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||R
|-
| ||[[Fusobacterium necrophorum]]||R
|-
| ||[[Peptostreptococcus sp.]]||R
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefsulodin - Revision history