Clonidine - Revision history

Danbot: Switch SMW query from broadtable to table format for better layout with TOC

2026-03-20T21:57:51Z

Switch SMW query from broadtable to table format for better layout with TOC

← Older revision		Revision as of 21:57, 20 March 2026
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	\|?Has Route=Route		\|?Has Route=Route
	\|?Has Population=Population		\|?Has Population=Population
	\|format=~~broadtable~~		\|format=table
	\|headers=plain		\|headers=plain
	\|mainlabel=-		\|mainlabel=-

Ostermayer: /* Mechanism of Action */

2026-03-20T21:49:59Z

Mechanism of Action

@@ Line 45: / Line 45: @@
 *Stimulates alpha-2 adrenergic receptors in the brainstem, reducing sympathetic outflow from the CNS
 *Decreases peripheral resistance, heart rate, and blood pressure
 ==See Also==

Ostermayer: /* Adult Dosing */

2026-03-20T21:49:37Z

Adult Dosing

@@ Line 9: / Line 9: @@
 *Hypertension: 0.1mg PO BID, titrate as needed
 *Acute hypertension: 0.1-0.2mg PO, may repeat hourly (max 0.6mg)
 ==Pediatric Dosing==

Danbot: Create standalone drug page for Clonidine (was redirecting to Clonidine toxicity); add SMW query for MedicationDose

2026-03-20T21:23:08Z

Create standalone drug page for Clonidine (was redirecting to Clonidine toxicity); add SMW query for MedicationDose

← Older revision		Revision as of 21:23, 20 March 2026
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	#~~REDIRECT~~[[Clonidine toxicity]]		==Administration==
			*Type: [[Antihypertensive]], Central alpha-2 agonist
			*Dosage Forms: Tablets (0.1mg, 0.2mg, 0.3mg); Transdermal patches; Injectable
			*Routes of Administration: PO, IV, Transdermal
			*Common Trade Names: Catapres, Duraclon

			==Adult Dosing==
			===General===
			*Hypertension: 0.1mg PO BID, titrate as needed
			*Acute hypertension: 0.1-0.2mg PO, may repeat hourly (max 0.6mg)
			===Indications by Condition===
			{{#ask:[[Has DrugName::Clonidine]]
			\|?Has Indication=Indication
			\|?Has Dose=Dose
			\|?Has Context=Context
			\|?Has Route=Route
			\|?Has Population=Population
			\|format=broadtable
			\|headers=plain
			\|mainlabel=-
			\|sort=Has Indication
			\|limit=50
			}}

			==Pediatric Dosing==
			===General===
			*5-10mcg/kg/day PO divided q8-12h

			==Special Populations==
			*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
			*[[Lactation risk categories\|Lactation risk]]: Enters breast milk, use caution
			===Renal Dosing===
			*Adjust dose; reduce in renal impairment
			===Hepatic Dosing===
			*Use caution in hepatic impairment

			==Contraindications==
			*Allergy to class/drug

			==Adverse Drug Reactions==
			===Serious===
			*Rebound hypertension with abrupt discontinuation
			*Bradycardia
			*Hypotension
			===Common===
			*Dry mouth
			*Drowsiness/sedation
			*Constipation
			*Dizziness

			==Pharmacology==
			*Onset of action: 30-60 minutes (PO)
			*Half-life: 12-16 hours
			*Metabolism: Hepatic (50%)
			*Excretion: Renal (40-60% unchanged)

			==Mechanism of Action==
			*Stimulates alpha-2 adrenergic receptors in the brainstem, reducing sympathetic outflow from the CNS
			*Decreases peripheral resistance, heart rate, and blood pressure

			==See Also==
			*[[Clonidine toxicity]]
			*[[Opioid withdrawal]]
			*[[Hypertensive emergency]]
			*[[Antihypertensives]]

			==References==
			<references/>

			[[Category:Pharmacology]]
			[[Category:Cardiology]]

Rossdonaldson1: Redirected page to Clonidine toxicity

2015-03-24T14:59:37Z

Redirected page to Clonidine toxicity

← Older revision		Revision as of 14:59, 24 March 2015
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	#REDIRECT[[Clonidine ~~Toxicity~~]]		#REDIRECT[[Clonidine toxicity]]

Rossdonaldson1: Redirected page to Clonidine Toxicity

2013-09-26T17:35:17Z

Redirected page to Clonidine Toxicity

New page

#REDIRECT[[Clonidine Toxicity]]