Cobalt toxicity - Revision history

Blsimpso: /* Management */

2021-06-28T19:24:45Z

Management

← Older revision		Revision as of 19:24, 28 June 2021
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	''There is no consensus regarding treatment of patients with systemic symptoms of cobalt toxicity''<ref>Dwyer, J., 2021. Final Diagnosis-Elevated Blood Cobalt Levels in Patients with Metal-on-Metal Prosthesis. [online] Available at: <https://path.upmc.edu/cases/case806/dx.html> [Accessed 28 June 2021].</ref>		''There is no consensus regarding treatment of patients with systemic symptoms of cobalt toxicity''<ref>Dwyer, J., 2021. Final Diagnosis-Elevated Blood Cobalt Levels in Patients with Metal-on-Metal Prosthesis. [online] Available at: <https://path.upmc.edu/cases/case806/dx.html> [Accessed 28 June 2021].</ref>
	*Manage symptoms supportively		*Manage symptoms supportively
	**Treat hypothyroidism (thyroid replacement therapy)		**Treat [[hypothyroidism]] (thyroid replacement therapy)
	**Treat cardiomyopathy(beta-blockers/ACE-inhibitors/diuresis)		**Treat [[cardiomyopathy]](beta-blockers/ACE-inhibitors/diuresis)
	*No conclusive evidence for ~~plasmapharesis~~ or chelation therapy<ref>Mohan, N., 2016. Identification and Management of Cobalt Toxicity: A Case Report of Rapidly Progressing Toxicity after Hip Arthroplasty Revision. [online] Jdc.jefferson.edu. Available at: <https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1359&context=tmf> [Accessed 28 June 2021].</ref>		*No conclusive evidence for [[plasmapheresis]] or chelation therapy<ref>Mohan, N., 2016. Identification and Management of Cobalt Toxicity: A Case Report of Rapidly Progressing Toxicity after Hip Arthroplasty Revision. [online] Jdc.jefferson.edu. Available at: <https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1359&context=tmf> [Accessed 28 June 2021].</ref>

	==Disposition==		==Disposition==

Blsimpso: /* Management */

2021-06-28T19:21:23Z

Management

← Older revision		Revision as of 19:21, 28 June 2021
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	==Management==		==Management==
			''There is no consensus regarding treatment of patients with systemic symptoms of cobalt toxicity''<ref>Dwyer, J., 2021. Final Diagnosis-Elevated Blood Cobalt Levels in Patients with Metal-on-Metal Prosthesis. [online] Available at: <https://path.upmc.edu/cases/case806/dx.html> [Accessed 28 June 2021].</ref>
			*Manage symptoms supportively
			**Treat hypothyroidism (thyroid replacement therapy)
			**Treat cardiomyopathy(beta-blockers/ACE-inhibitors/diuresis)
			*No conclusive evidence for plasmapharesis or chelation therapy<ref>Mohan, N., 2016. Identification and Management of Cobalt Toxicity: A Case Report of Rapidly Progressing Toxicity after Hip Arthroplasty Revision. [online] Jdc.jefferson.edu. Available at: <https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1359&context=tmf> [Accessed 28 June 2021].</ref>

	==Disposition==		==Disposition==

Blsimpso: /* Background */

2021-06-28T18:47:42Z

Background

← Older revision		Revision as of 18:47, 28 June 2021
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	==Background==		==Background==
	*Orthopedic hip prostheses ~~contain~~ cobalt ~~and are a possible source~~ of ~~toxicity.~~		*Cobalt is essential for life as a catalytic center for vitamin B12. Toxicity is rare.
			*Cobalt toxicity has been reported through the following exposures:<ref>Simonsen, L., 2012. Cobalt metabolism and toxicology—A brief update.</ref>
			**Orthopedic hip prostheses containing cobalt
			**Work-related cobalt exposure
			**Excessive drinking of beer containing cobalt sulfate

	==Clinical Features<ref>Devlin, J., 2021. Clinical Features, Testing, and Management of Patients with Suspected Prosthetic Hip-Associated Cobalt Toxicity: a Systematic Review of Cases.</ref>==		==Clinical Features<ref>Devlin, J., 2021. Clinical Features, Testing, and Management of Patients with Suspected Prosthetic Hip-Associated Cobalt Toxicity: a Systematic Review of Cases.</ref>==

Blsimpso: /* Clinical Features */

2021-06-28T18:13:55Z

Clinical Features

← Older revision		Revision as of 18:13, 28 June 2021
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	*Orthopedic hip prostheses contain cobalt and are a possible source of toxicity.		*Orthopedic hip prostheses contain cobalt and are a possible source of toxicity.

	==Clinical Features==		==Clinical Features<ref>Devlin, J., 2021. Clinical Features, Testing, and Management of Patients with Suspected Prosthetic Hip-Associated Cobalt Toxicity: a Systematic Review of Cases.</ref>==
			* '''Neurologic Dysfunction'''
			**Hearing impairment
			**Cognitive impairment
			**Parasthesias
			*'''Cardiovascular Dysfunction'''
			**Beer drinkers' (dilated) cardiomyopathy
			**[[Dyspnea]]
			**[[Atrial fibrillation]]
			*'''Thyroid Dysfunction'''
			**[[Hypothyroidism]]

	==Differential Diagnosis==		==Differential Diagnosis==

Elcatracho: /* See Also */

2021-03-09T01:15:46Z

Mholtz: Created page with "==Background== *Orthopedic hip prostheses contain cobalt and are a possible source of toxicity. ==Clinical Features== ==Differential Diagnosis== {{Heavy metals list}} ==Ev..."

2017-10-23T09:21:20Z

Created page with "==Background== *Orthopedic hip prostheses contain cobalt and are a possible source of toxicity. ==Clinical Features== ==Differential Diagnosis== {{Heavy metals list}} ==Ev..."

New page

==Background==
*Orthopedic hip prostheses contain cobalt and are a possible source of toxicity.

==Clinical Features==

==Differential Diagnosis==
{{Heavy metals list}}

==Evaluation==

==Management==

==Disposition==

==See Also==

==External Links==

==References==
<references/>

[[Category:Toxicology]]

← Older revision		Revision as of 01:15, 9 March 2021
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	==See Also==		==See Also==
			*[[Toxicology (main)]]
			*[[Heavy Metals]]

	==External Links==		==External Links==