Colchicine toxicity - Revision history

Rossdonaldson1: Text replacement - "Troponin" to "Troponin"

2019-07-01T20:55:23Z

Text replacement - "*Troponin" to "*Troponin"

← Older revision		Revision as of 20:55, 1 July 2019
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	*CXR		*CXR
	*Depending on clinical situation		*Depending on clinical situation
	**Troponin		**[[Troponin]]
	**ABG		**ABG
	**Lactate		**Lactate

ClaireLewis: /* Management */

2019-02-01T20:24:35Z

Management

← Older revision		Revision as of 20:24, 1 February 2019
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	*Supportive care		*Supportive care
	*GI Decontamination		*GI Decontamination
	**[[~~Orogastric~~ lavage]] in patients who present within 1-2 hours without vomiting		**Oro[[gastric lavage]] in patients who present within 1-2 hours without vomiting
	**[[Activated charcoal]] and consider [[Multidose activated charcoal]]		**[[Activated charcoal]] and consider [[Multidose activated charcoal]]
	*Antidotal therapy		*Antidotal therapy

Rossdonaldson1: Text replacement - "UA" to "Urinalysis"

2018-10-21T00:36:58Z

Text replacement - "*UA" to "*Urinalysis"

← Older revision		Revision as of 00:36, 21 October 2018
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	*Coagulation factors		*Coagulation factors
	*CPK		*CPK
	*UA		*[[Urinalysis]]
	*EKG		*EKG
	*CXR		*CXR

Rossdonaldson1: Text replacement - "Poison Control Center" to "poison control"

2018-08-14T10:24:54Z

Text replacement - "Poison Control Center" to "poison control"

← Older revision		Revision as of 10:24, 14 August 2018
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	*All symptomatic patients require admission to ICU		*All symptomatic patients require admission to ICU
	*Patients who do not develop GI symptoms within 8-12 hours after ingestion likely have not developed significant poisoning		*Patients who do not develop GI symptoms within 8-12 hours after ingestion likely have not developed significant poisoning
	*Consult Toxicology or ~~Poison Control Center~~		*Consult Toxicology or [[poison control]]

	==References==		==References==

Therriac: /* Management */

2018-08-10T23:05:06Z

Management

← Older revision		Revision as of 23:05, 10 August 2018
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	*GI Decontamination		*GI Decontamination
	**[[Orogastric lavage]] in patients who present within 1-2 hours without vomiting		**[[Orogastric lavage]] in patients who present within 1-2 hours without vomiting
	**[[Activated charcoal]] and consider [[~~MDAC~~]]		**[[Activated charcoal]] and consider [[Multidose activated charcoal]]
	*Antidotal therapy		*Antidotal therapy
	**Colchine-specific Fab fragments		**Colchine-specific Fab fragments

Therriac: /* Background */

2018-08-10T18:22:02Z

Background

← Older revision		Revision as of 18:22, 10 August 2018
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	*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)		*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)
	**C. autumnale resembles wild garlic [[File:Colchicum autumnale 2c.JPG\|thumb\|C. autumnale]]		**C. autumnale resembles wild garlic [[File:Colchicum autumnale 2c.JPG\|thumb\|C. autumnale]]
	**G. superba may be confused for sweet potatoes		**G. superba may be confused for sweet potatoes [[File:Gloriosa superba (Glory Lily) in Hyderabad, AP W IMG 0224.jpg\|thumb\|G. superba]]
	*First published in the first century in ''Pedanius Dioscorides De Materia Medica''		*First published in the first century in ''Pedanius Dioscorides De Materia Medica''
	===Uses===		===Uses===

Therriac: /* Background */

2018-08-10T18:19:10Z

Background

← Older revision		Revision as of 18:19, 10 August 2018
Line 1:		Line 1:
	==Background==		==Background==
	*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)		*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)
	**C. autumnale resembles wild garlic [[File:~~Colchicum_autumnale_2c~~.JPG~~.jpg~~\|thumb\|C. autumnale]]		**C. autumnale resembles wild garlic [[File:Colchicum autumnale 2c.JPG\|thumb\|C. autumnale]]
	**G. superba may be confused for sweet potatoes		**G. superba may be confused for sweet potatoes
	*First published in the first century in ''Pedanius Dioscorides De Materia Medica''		*First published in the first century in ''Pedanius Dioscorides De Materia Medica''

Therriac: /* Background */

2018-08-10T18:18:34Z

Background

← Older revision		Revision as of 18:18, 10 August 2018
Line 1:		Line 1:
	==Background==		==Background==
	*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily) [[File:~~Colchicum autumnale 002~~.JPG\|~~Colchicum~~ autumnale ~~002~~]]		*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)
	**C. autumnale resembles wild garlic		**C. autumnale resembles wild garlic [[File:Colchicum_autumnale_2c.JPG.jpg\|thumb\|C. autumnale]]
	**G. superba may be confused for sweet potatoes		**G. superba may be confused for sweet potatoes
	*First published in the first century in ''Pedanius Dioscorides De Materia Medica''		*First published in the first century in ''Pedanius Dioscorides De Materia Medica''
Line 20:		Line 20:
	*Serum half-life 9-108 minutes		*Serum half-life 9-108 minutes
	*Toxicity usually occurs at levels >3ng/ml		*Toxicity usually occurs at levels >3ng/ml

	==Clinical Features==		==Clinical Features==
	===Triphasic===		===Triphasic===

Therriac at 18:10, 10 August 2018

2018-08-10T18:10:22Z

← Older revision		Revision as of 18:10, 10 August 2018
Line 1:		Line 1:
	==Background==		==Background==
	*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)		*Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily) [[File:Colchicum autumnale 002.JPG\|Colchicum autumnale 002]]
	**C. autumnale resembles wild garlic		**C. autumnale resembles wild garlic
	**G. superba may be confused for sweet potatoes		**G. superba may be confused for sweet potatoes

Therriac at 18:04, 10 August 2018

2018-08-10T18:04:42Z

@@ Line 1: / Line 1: @@
 ==Background==
 *Derived from C. autumnale (wild saffron, meadow saffron, autum crocus, naked lady) and G. superba (glory lily)
-**C. autumnale resembles wild garlic [[File:https://upload.wikimedia.org/wikipedia/commons/5/53/Colchicum_autumnale_002.JPG|thumbnail]]
+**C. autumnale resembles wild garlic
 **G. superba may be confused for sweet potatoes
 *First published in the first century in ''Pedanius Dioscorides De Materia Medica''
 ===Uses===
+*Gout
 ===Toxicokinetics===
+*Inhibitor of microtubule formation and function
+*Rapidly absorbed in the jenjunum and ileum
 ==Clinical Features==
-===Acute===
+===Triphasic===
+*Phase I
+**Onset 12-24 hours post ingestion
 ==Differential Diagnosis==
 ===[[Heavy metal]] toxicity===
@@ Line 39: / Line 77: @@
 *[[Zinc toxicity]]
 ==Evaluation==
 *BMP
 *LFTs
 *CBC
 *CPK
 *EKG
+*CXR
 ==Management==
+*Supportive care
 ==Disposition==
 *Consult Toxicology or Poison Control Center

Colchicine toxicity - Revision history

Rossdonaldson1: Text replacement - "*Troponin" to "*Troponin"

ClaireLewis: /* Management */

Rossdonaldson1: Text replacement - "*UA" to "*Urinalysis"

Rossdonaldson1: Text replacement - "Poison Control Center" to "poison control"

Therriac: /* Management */

Therriac: /* Background */

Therriac: /* Background */

Therriac: /* Background */

Therriac at 18:10, 10 August 2018

Therriac at 18:04, 10 August 2018

Rossdonaldson1: Text replacement - "Troponin" to "Troponin"

Rossdonaldson1: Text replacement - "UA" to "Urinalysis"