Cyclosporine - Revision history

Neil.m.young: Text replacement - "Cr " to "creatinine "

2016-08-11T07:21:25Z

Text replacement - "Cr " to "creatinine "

← Older revision		Revision as of 07:21, 11 August 2016
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	===Common===		===Common===
	*BUN, Cr elevated		*BUN, creatinine elevated
	*hypertension		*hypertension
	*hirsutism		*hirsutism

Rossdonaldson1: Text replacement - "HTN" to "hypertension"

2016-07-31T02:43:58Z

Text replacement - "HTN" to "hypertension"

← Older revision		Revision as of 02:43, 31 July 2016
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*~~HTN~~, severe		*hypertension, severe
	*immunosuppression		*immunosuppression
	*infection, severe		*infection, severe
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	===Common===		===Common===
	*BUN, Cr elevated		*BUN, Cr elevated
	*~~HTN~~		*hypertension
	*hirsutism		*hirsutism
	*infection		*infection

Neil.m.young: Text replacement - "5 mg" to "5mg"

2016-07-21T10:31:28Z

Text replacement - "5 mg" to "5mg"

← Older revision		Revision as of 10:31, 21 July 2016
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	===Rheumatoid arthritis, severe===		===Rheumatoid arthritis, severe===
	*Start: 2.~~5 mg~~/kg/day PO divided BID, increase 0.5-0.~~75 mg~~/kg/day after 8 wk and after 12 wk; Max: 4mg/kg/day		*Start: 2.5mg/kg/day PO divided BID, increase 0.5-0.75mg/kg/day after 8 wk and after 12 wk; Max: 4mg/kg/day
	*Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks		*Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks

	===Psoriasis, severe recalcitrant plaque===		===Psoriasis, severe recalcitrant plaque===
	*Start: 2.~~5 mg~~/kg/day PO divided BID, increase 0.~~5 mg~~/kg/day q 2 wk after 4 wk; Max: 4mg/kg/day		*Start: 2.5mg/kg/day PO divided BID, increase 0.5mg/kg/day q 2 wk after 4 wk; Max: 4mg/kg/day
	*Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose		*Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose

Neil.m.young: Text replacement - "4 mg" to "4mg"

2016-07-19T02:57:47Z

Text replacement - "4 mg" to "4mg"

← Older revision		Revision as of 02:57, 19 July 2016
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	===Rheumatoid arthritis, severe===		===Rheumatoid arthritis, severe===
	*Start: 2.5 mg/kg/day PO divided BID, increase 0.5-0.75 mg/kg/day after 8 wk and after 12 wk; Max: ~~4 mg~~/kg/day		*Start: 2.5 mg/kg/day PO divided BID, increase 0.5-0.75 mg/kg/day after 8 wk and after 12 wk; Max: 4mg/kg/day
	*Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks		*Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks

	===Psoriasis, severe recalcitrant plaque===		===Psoriasis, severe recalcitrant plaque===
	*Start: 2.5 mg/kg/day PO divided BID, increase 0.5 mg/kg/day q 2 wk after 4 wk; Max: ~~4 mg~~/kg/day		*Start: 2.5 mg/kg/day PO divided BID, increase 0.5 mg/kg/day q 2 wk after 4 wk; Max: 4mg/kg/day
	*Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose		*Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose

Neil.m.young: Text replacement - "9 mg" to "9mg"

2016-07-18T19:07:01Z

Text replacement - "9 mg" to "9mg"

← Older revision		Revision as of 19:07, 18 July 2016
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	===Organ transplant rejection prophylaxis===		===Organ transplant rejection prophylaxis===
	*Dosing protocols vary		*Dosing protocols vary
	*Start: 7-~~9 mg~~/kg/day PO divided BID; give 1st dose 4-12 hr pre-transplant or postop		*Start: 7-9mg/kg/day PO divided BID; give 1st dose 4-12 hr pre-transplant or postop
	*For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects		*For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects

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	===Organ transplant rejection prophylaxis===		===Organ transplant rejection prophylaxis===
	*Dosing protocols vary		*Dosing protocols vary
	*Start 7-~~9 mg~~/kg/day PO divided BID, give 1st dose 4-12 hr pre-transplant or post op		*Start 7-9mg/kg/day PO divided BID, give 1st dose 4-12 hr pre-transplant or post op
	*For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects		*For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects

Rossdonaldson1: Text replacement - "tx" to "treatment"

2016-07-15T04:39:42Z

Text replacement - "tx" to "treatment"

← Older revision		Revision as of 04:39, 15 July 2016
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	*renal impairment (RA or psoriasis use)		*renal impairment (RA or psoriasis use)
	*malignancy (RA or psoriasis use)		*malignancy (RA or psoriasis use)
	*PUVA/UVB tx (psoriasis use)		*PUVA/UVB treatment (psoriasis use)
	*concurrent immunosuppressants (psoriasis use)		*concurrent immunosuppressants (psoriasis use)
	*coal tar tx (psoriasis use)		*coal tar treatment (psoriasis use)
	*concomitant XRT (psoriasis use)		*concomitant XRT (psoriasis use)

Neil.m.young: Text replacement - "* " to "*"

2016-07-04T11:11:36Z

Text replacement - "* " to "*"

← Older revision		Revision as of 11:11, 4 July 2016
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	==Adult Dosing==		==Adult Dosing==
	===Organ transplant rejection prophylaxis===		===Organ transplant rejection prophylaxis===
	* Dosing protocols vary		*Dosing protocols vary
	* Start: 7-9 mg/kg/day PO divided BID; give 1st dose 4-12 hr pre-transplant or postop		*Start: 7-9 mg/kg/day PO divided BID; give 1st dose 4-12 hr pre-transplant or postop
	* For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects		*For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects

	===Rheumatoid arthritis, severe===		===Rheumatoid arthritis, severe===
	* Start: 2.5 mg/kg/day PO divided BID, increase 0.5-0.75 mg/kg/day after 8 wk and after 12 wk; Max: 4 mg/kg/day		*Start: 2.5 mg/kg/day PO divided BID, increase 0.5-0.75 mg/kg/day after 8 wk and after 12 wk; Max: 4 mg/kg/day
	* Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks		*Use alone or with methotrexate; decreased 25-50% PRN adverse effects, discontinue if no benefit by 16 wks

	===Psoriasis, severe recalcitrant plaque===		===Psoriasis, severe recalcitrant plaque===
	* Start: 2.5 mg/kg/day PO divided BID, increase 0.5 mg/kg/day q 2 wk after 4 wk; Max: 4 mg/kg/day		*Start: 2.5 mg/kg/day PO divided BID, increase 0.5 mg/kg/day q 2 wk after 4 wk; Max: 4 mg/kg/day
	* Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose		*Decrease 25-50% PRN adverse effects, discontinue if inadequate response after 6 weeks on max tolerated dose

	==Pediatric Dosing==		==Pediatric Dosing==
	===Organ transplant rejection prophylaxis===		===Organ transplant rejection prophylaxis===
	* Dosing protocols vary		*Dosing protocols vary
	* Start 7-9 mg/kg/day PO divided BID, give 1st dose 4-12 hr pre-transplant or post op		*Start 7-9 mg/kg/day PO divided BID, give 1st dose 4-12 hr pre-transplant or post op
	* For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects		*For heart, kidney, or liver transplant, adjust dose based on target levels, rejection status, adverse effects

	==Special Populations==		==Special Populations==
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	**rheumatoid arthritis or psoriasis: contraindicated in renal impairment		**rheumatoid arthritis or psoriasis: contraindicated in renal impairment
	*Pediatric:		*Pediatric:
	** transplant: no adjustment		**transplant: no adjustment
	===Hepatic Dosing===		===Hepatic Dosing===
	*Adult: not defined, caution advised		*Adult: not defined, caution advised

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:53:24Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:53, 22 March 2016
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	==References==		==References==
	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]
	epocrates		epocrates

Janelim: references

2016-02-09T02:24:51Z

references

← Older revision		Revision as of 02:24, 9 February 2016
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	<references/>		<references/>
	[[Category:Drugs]]		[[Category:Drugs]]
			epocrates

Janelim: mechanism of action

2016-02-09T02:24:33Z

mechanism of action

← Older revision		Revision as of 02:24, 9 February 2016
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	==Mechanism of Action==		==Mechanism of Action==
			exact mechanism of action unknown; inhibits T-lymphocytes

	==Comments==		==Comments==