https://wikem.org/w/index.php?action=history&feed=atom&title=Doxapram 2026-04-16T02:27:48Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Doxapram&diff=181307&oldid=prev 2018-06-10T13:52:46Z

<p>Text replacement - &quot;w/&quot; to &quot;with&quot;</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:52, 10 June 2018</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l63">Line 63:</td> <td colspan="2" class="diff-lineno">Line 63:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Seizure]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[[Seizure]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Hallucinations</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Hallucinations</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*Hemolysis <del style="font-weight: bold; text-decoration: none;">w/ </del>rapid infusion</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Hemolysis <ins style="font-weight: bold; text-decoration: none;">with </ins>rapid infusion</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Common===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Common===</div></td></tr> </table>

Mholtz https://wikem.org/w/index.php?title=Doxapram&diff=165985&oldid=prev 2017-11-28T21:13:06Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Respiratory Stimulator<br /> *Dosage Forms: INJ<br /> *Routes of Administration: IV<br /> *Common Trade Names: Dopram<br /> <br /> ==Adult Dosing==<br /> ===Respiratory depression, postanesthesia===<br /> *Intermittent Injection<br /> **0.5-1 mg/kg IV q5min prn<br /> ***Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h<br /> *Intermittent infusion<br /> **0.5-1 mg/kg IV<br /> ***Max: 4 mg/kg/dose, 3 g/24h<br /> ===CNS depression, drug-induced===<br /> *Intermittent Injection<br /> **1-2 mg/kg IV q1-2h prn<br /> *Intermittent infusion<br /> **1-3 mg/kg/h IV up to 2h<br /> ===Acute hypercapnia, COPD-assoc.===<br /> *1-3 mg/min IV up to 2h<br /> <br /> ==Pediatric Dosing==<br /> ===Respiratory depression, postanesthesia===<br /> *Intermittent Injection<br /> **0.5-1 mg/kg IV q5min prn<br /> ***Max: 1.5 mg/kg/single dose, 2 mg/kg/total dose, 3g/24h<br /> *Intermittent infusion<br /> **0.5-1 mg/kg IV<br /> ***Max: 4 mg/kg/dose, 3 g/24h<br /> ===CNS depression, drug-induced===<br /> *Intermittent Injection<br /> **1-2 mg/kg IV q1-2h prn<br /> *Intermittent infusion<br /> **1-3 mg/kg/h IV up to 2h<br /> <br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: C<br /> *Lactation risk: No current data to asses risk<br /> ===Renal Dosing===<br /> *Adult: Caution advised in significant impairment<br /> *Pediatric: Caution advised in significant impairment<br /> ===Hepatic Dosing===<br /> *Adult: Caution advised in significant impairment<br /> *Pediatric: Caution advised in significant impairment<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Concurrent mechanical ventilation<br /> *Mechanical disorders of ventilation<br /> *[[Seizure]] disorder<br /> *[[Pulmonary embolism]]<br /> *Head injury<br /> *[[Stroke]]<br /> *Cerebral edema<br /> *Cardiovascular impairment, Heart failure, HTN<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *[[Bronchospasm]], laryngospasm<br /> *[[Arrhythmia]]<br /> *[[HTN]]<br /> *[[Seizure]]<br /> *Hallucinations<br /> *Hemolysis w/ rapid infusion<br /> <br /> ===Common===<br /> *[[Fever]], flushing, diaphoresis<br /> *Pruritis, parasthesia<br /> *Mydriasis<br /> *Hallucination<br /> *[[Headache]], [[dizziness]]<br /> *Hyperactivity, involuntary movements, muscle spasms<br /> *[[Seizure]]<br /> *[[Dyspnea]], cough, hyperventilation, [[tachypnea]]<br /> *Phlebitis<br /> *[[Diarrhea]], Urinary incontinence, urinary retention<br /> <br /> ==Pharmacology==<br /> *Half-life: 3.4h<br /> *Metabolism: Liver<br /> *Excretion: Urine (&lt;5% unchanged)<br /> <br /> ==Mechanism of Action==<br /> *Acts on peripheral carotid chemoreceptors to stimulate respiration<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

Jonwarren