EBQ:ARDSnet Trial - Revision history

Danbot: Added Study Design and Criticisms sections

2026-03-21T22:36:53Z

Added Study Design and Criticisms sections

← Older revision		Revision as of 22:36, 21 March 2026
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	*Enrollment: March 1996 to March 1999 (terminated early after the fourth interim analysis)		*Enrollment: March 1996 to March 1999 (terminated early after the fourth interim analysis)
	*Follow-up: 180 days or until home breathing independently		*Follow-up: 180 days or until home breathing independently

			==Study Design==
			*Multicenter, randomized, controlled trial
			*ARDS Network - 10 university medical centers
			*N = 861 patients
			*Primary Outcome: mortality before discharge with unassisted breathing
			*Enrollment period: March 1996 - March 1999

	==Population==		==Population==
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	==Criticisms==		==Criticisms==
			*Control group tidal volume (12 mL/kg) was higher than what many clinicians were already using at the time
			*Plateau pressures were not controlled independently of tidal volume, so it is unclear whether the benefit was from lower volume or lower pressure
			*PEEP levels were relatively low in both groups; higher PEEP strategies were not evaluated
			*Predicted body weight was used for calculations, which requires accurate height measurement
			*The trial was stopped early for efficacy, which may have overestimated treatment effect
	==Funding==		==Funding==
	The National Heart, Lung, and Blood Institute.		The National Heart, Lung, and Blood Institute.

2020-03-21T19:14:45Z

Sources

← Older revision		Revision as of 19:14, 21 March 2020
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	==Funding==		==Funding==
	The National Heart, Lung, and Blood Institute.		The National Heart, Lung, and Blood Institute.
	==~~Sources~~==		==See Also==
			{{Mechanical ventilation pages}}

			==References==
	<references/>		<references/>

	[[Category:Pulmonary]][[Category:Critical Care]][[Category:EBQ]]		[[Category:Pulmonary]][[Category:Critical Care]][[Category:EBQ]]

2016-07-14T02:19:07Z

Baseline Characteristics

2016-03-22T16:12:04Z

Text replacement - "Category:Pulm" to "Category:Pulmonary"

← Older revision		Revision as of 16:12, 22 March 2016
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	<references/>		<references/>

	[[Category:~~Pulm~~]][[Category:Critical Care]][[Category:EBQ]]		[[Category:Pulmonary]][[Category:Critical Care]][[Category:EBQ]]

2015-12-14T04:18:20Z

← Older revision		Revision as of 04:18, 14 December 2015
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	==Conclusion==		==Conclusion==
	In patients with ALI/ARDS, lower tidal volumes of 6mL/kg ~~ideal~~ body weight reduces mortality and decreases length of time on mechanical ventilation.		In patients with ALI/ARDS, lower tidal volumes of 6mL/kg predicted body weight reduces mortality and decreases length of time on mechanical ventilation.

	==Major Points==		==Major Points==

2015-05-25T21:13:41Z

Guidelines

← Older revision		Revision as of 21:13, 25 May 2015
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	*The trial was stopped early when patients in the low tidal volumes arm showed a significant decrease in mortality and more ventilator-free days compared to the traditional tidal volumes arm.		*The trial was stopped early when patients in the low tidal volumes arm showed a significant decrease in mortality and more ventilator-free days compared to the traditional tidal volumes arm.
	==Guidelines==		==Guidelines==
	See [[~~EBQ:Surviving_sepsis_2012\|Surviving~~ Sepsis ~~2012~~]]		See [[Sepsis]] for guideline recommendations

	==Design==		==Design==

2015-05-25T21:12:25Z

CME

@@ Line 109: / Line 109: @@
 ==Funding==
 The National Heart, Lung, and Blood Institute.
 ==Sources==
 <references/>
 [[Category:Pulm]][[Category:Critical Care]][[Category:EBQ]]

2014-01-19T03:30:52Z

← Older revision		Revision as of 03:30, 19 January 2014
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	\| fulltexturl=http://www.nejm.org/doi/full/10.1056/NEJM200005043421801		\| fulltexturl=http://www.nejm.org/doi/full/10.1056/NEJM200005043421801
	\| pdfurl=http://www.nejm.org/doi/pdf/10.1056/NEJM200005043421801		\| pdfurl=http://www.nejm.org/doi/pdf/10.1056/NEJM200005043421801
	\| status=~~Under Review~~		\| status=Complete
	}}		}}

2013-12-31T16:15:43Z

← Older revision	Revision as of 16:15, 31 December 2013
(No difference)

2013-12-31T16:06:42Z

← Older revision		Revision as of 16:06, 31 December 2013
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	\| fulltexturl=http://www.nejm.org/doi/full/10.1056/NEJM200005043421801		\| fulltexturl=http://www.nejm.org/doi/full/10.1056/NEJM200005043421801
	\| pdfurl=http://www.nejm.org/doi/pdf/10.1056/NEJM200005043421801		\| pdfurl=http://www.nejm.org/doi/pdf/10.1056/NEJM200005043421801
			\| status=Under Review
	}}		}}