Fresh frozen plasma - Revision history

Elcatracho: /* See Also */

2021-02-25T14:07:55Z

ClaireLewis: /* Adverse Reactions */

2020-12-28T02:01:12Z

Adverse Reactions

← Older revision		Revision as of 02:01, 28 December 2020
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	*[[Transfusion reactions]]		*[[Transfusion reactions]]
	**[[Intravascular hemolytic transfusion reaction\|Hemolytic transfusion reactions]]		**[[Intravascular hemolytic transfusion reaction\|Hemolytic transfusion reactions]]
	**[[Febrile nonhemolytic reaction]]		**[[Febrile nonhemolytic transfusion reaction]]
	**[[Transfusion-associated circulatory overload]] (TACO)		**[[Transfusion-associated circulatory overload]] (TACO)
	**[[Transfusion-related acute lung injury]] (TRALI)		**[[Transfusion-related acute lung injury]] (TRALI)

ClaireLewis at 02:00, 28 December 2020

2020-12-28T02:00:52Z

← Older revision		Revision as of 02:00, 28 December 2020
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	==Indications==		==Indications==
	*Rapid reversal of warfarin anticoagulation (in setting of bleeding or need for invasive procedure)		*Rapid [[warfarin reversal\|reversal of warfarin]] anticoagulation (in setting of bleeding or need for invasive procedure)
	*Bleeding and multiple coagulation defects (e.g. DIC with significant PT/PTT elevation)		*[[hemorrhage\|Bleeding]] and multiple [[coagulopathy\|coagulation defects]] (e.g. [[DIC]] with significant PT/PTT elevation)
	*Correction of coagulation defects for which no specific factor is available		*Correction of coagulation defects for which no specific factor is available
	*Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy		*[[Transfusion]] of more than one blood volume with evidence of active bleeding + coagulopathy

	==Adult Dosing==		==Adult Dosing==
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*Hemolytic transfusion reactions		*[[Transfusion reactions]]
	*Febrile ~~non-hemolytic reactions~~		**[[Intravascular hemolytic transfusion reaction\|Hemolytic transfusion reactions]]
	*Transfusion-associated circulatory overload (TACO)		**[[Febrile nonhemolytic reaction]]
	*Transfusion-related acute lung injury (TRALI)		**[[Transfusion-associated circulatory overload]] (TACO)
	*Transfusion-associated graft-versus-host disease		**[[Transfusion-related acute lung injury]] (TRALI)
	*Anaphylaxis		**[[Transfusion-associated graft-versus-host disease]]
	*Sepsis		*[[Anaphylaxis]]
			*[[Sepsis]]
	===Common===		===Common===
	*Headache, paresthesia		*Headache, paresthesia
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	**40 mL/kg raises any factor by 100% (each unit is ~200mL)		**40 mL/kg raises any factor by 100% (each unit is ~200mL)
	*May cause fluid overload		*May cause fluid overload
	*ABO ~~compatibilty~~ a must but crossmatch before transfusing not		*ABO compatibility a must but crossmatch before transfusing not
	*INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised<ref>Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9. </ref>		*INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised<ref>Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9. </ref>
	*Retains active coagulation factors for up to 5 days after being thawed		*Retains active coagulation factors for up to 5 days after being thawed

Elcatracho: /* Adult Dosing */

2020-12-23T05:04:55Z

Adult Dosing

← Older revision		Revision as of 05:04, 23 December 2020
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	*10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30%		*10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30%
	*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)		*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)
			*Must be thawed in 37 degree Celsius water bath for about 45 minutes prior to administration<ref>Westphal RG, Tindle B, Howard PL, Golden EA, Page GA. Rapid thawing of fresh frozen plasma. Am J Clin Pathol. 1982;78(2):220-222. doi:10.1093/ajcp/78.2.220</ref>

	==Pediatric Dosing==		==Pediatric Dosing==

ClaireLewis at 22:14, 11 August 2017

2017-08-11T22:14:23Z

← Older revision		Revision as of 22:14, 11 August 2017
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	*Dosage Forms:		*Dosage Forms:
	*Common Trade Names:		*Common Trade Names:

			==Indications==
			*Rapid reversal of warfarin anticoagulation (in setting of bleeding or need for invasive procedure)
			*Bleeding and multiple coagulation defects (e.g. DIC with significant PT/PTT elevation)
			*Correction of coagulation defects for which no specific factor is available
			*Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy

	==Adult Dosing==		==Adult Dosing==
			*1 bag = 1 unit = 250 mL
			*10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30%
	*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)		*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)

	==Pediatric Dosing==		==Pediatric Dosing==
			*Neonates/small children: 10-20 mL/kg will increase factor levels by 15-25%

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*Lactation:		*Lactation:
	*Renal Dosing		*Renal Dosing:
	**Adult		*Hepatic Dosing:
	**Pediatric
	*Hepatic Dosing
	**Adult
	**Pediatric

	~~==Indications==~~
	*Rapid reversal of warfarin over-anticoagulation
	*Bleeding and multiple coagulation defects
	*Correction of coagulation defects for which no specific factor is available
	*Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*ABO incompatibility

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Hemolytic transfusion reactions
			*Febrile non-hemolytic reactions
			*Transfusion-associated circulatory overload (TACO)
			*Transfusion-related acute lung injury (TRALI)
			*Transfusion-associated graft-versus-host disease
			*Anaphylaxis
			*Sepsis
	===Common===		===Common===
			*Headache, paresthesia
			*Nausea
			*Pruritus, urticaria

	==Pharmacology==		==Pharmacology==

Neil.m.young: Text replacement - " w/ " to " with "

2016-07-12T05:18:24Z

Text replacement - " w/ " to " with "

← Older revision		Revision as of 05:18, 12 July 2016
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	*Bleeding and multiple coagulation defects		*Bleeding and multiple coagulation defects
	*Correction of coagulation defects for which no specific factor is available		*Correction of coagulation defects for which no specific factor is available
	*Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy		*Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy

	==Contraindications==		==Contraindications==

Ostermayer: Text replacement - "Category:Drugs" to "Category:Pharmacology"

2016-03-22T15:53:16Z

Text replacement - "Category:Drugs" to "Category:Pharmacology"

← Older revision		Revision as of 15:53, 22 March 2016
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	==References==		==References==
	<references/>		<references/>
	[[Category:~~Drugs~~]]		[[Category:Pharmacology]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Rossdonaldson1: /* Comments */

2015-06-01T22:13:33Z

Comments

← Older revision		Revision as of 22:13, 1 June 2015
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	*May cause fluid overload		*May cause fluid overload
	*ABO compatibilty a must but crossmatch before transfusing not		*ABO compatibilty a must but crossmatch before transfusing not
	*INR of FFP is ~1.6; therefore transfusing for INR >1.7 is not advised<ref>Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9. </ref>		*INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised<ref>Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9. </ref>
	*Retains active coagulation factors for up to 5 days after being thawed		*Retains active coagulation factors for up to 5 days after being thawed

Neil.m.young at 16:58, 1 June 2015

2015-06-01T16:58:29Z

← Older revision		Revision as of 16:58, 1 June 2015
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	*May cause fluid overload		*May cause fluid overload
	*ABO compatibilty a must but crossmatch before transfusing not		*ABO compatibilty a must but crossmatch before transfusing not
	*INR of FFP is ~1.2		*INR of FFP is ~1.6; therefore transfusing for INR >1.7 is not advised<ref>Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9. </ref>
	*Retains active coagulation factors for up to 5 days after being thawed		*Retains active coagulation factors for up to 5 days after being thawed

Rossdonaldson1 at 18:13, 29 May 2015

2015-05-29T18:13:41Z

← Older revision		Revision as of 18:13, 29 May 2015
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	==~~Features~~==		==General==
	~~#Contains all coagulation factors and fibrinogen~~		*Type: [[Blood products]]
	~~##40~~ mL/kg ~~raises any factor by 100%~~ (~~each unit is ~200mL~~)		*Dosage Forms:
	~~#May cause fluid overload~~		*Common Trade Names:
	~~#ABO compatibilty a must but crossmatch before transfusing not~~
	~~#INR of FFP is ~1.2~~		==Adult Dosing==
	~~#Retains active coagulation factors for up to 5 days after being thawed~~		*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)

			==Pediatric Dosing==

			==Special Populations==
			*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]:
			*Lactation:
			*Renal Dosing
			**Adult
			**Pediatric
			*Hepatic Dosing
			**Adult
			**Pediatric

	==Indications==		==Indications==
	#Rapid reversal of warfarin over-anticoagulation		*Rapid reversal of warfarin over-anticoagulation
	#Bleeding and multiple coagulation defects		*Bleeding and multiple coagulation defects
	#Correction of coagulation defects for which no specific factor is available		*Correction of coagulation defects for which no specific factor is available
	#Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy		*Transfusion of more than one blood volume w/ evidence of active bleeding + coagulopathy

			==Contraindications==
			*Allergy to class/drug

			==Adverse Reactions==
			===Serious===

			===Common===

			==Pharmacology==
			*Half-life:
			*Metabolism:
			*Excretion:
			*Mechanism of Action:

	==~~Dose~~==		==Comments==
	~~#Transfuse at least 15~~ mL/kg ~~at a time~~ (~~4 units in 70-kg adult~~)		*Contains all coagulation factors and fibrinogen
			**40 mL/kg raises any factor by 100% (each unit is ~200mL)
			*May cause fluid overload
			*ABO compatibilty a must but crossmatch before transfusing not
			*INR of FFP is ~1.2
			*Retains active coagulation factors for up to 5 days after being thawed

	==See Also==		==See Also==
	*[[Transfusions]]		*[[Transfusions]]

	==~~Source~~==		==References==
	~~Tintinalli~~		<references/>

	[[Category:Drugs]]		[[Category:Drugs]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

← Older revision		Revision as of 14:07, 25 February 2021
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	==See Also==		==See Also==
	*[[Transfusions]]		*[[Transfusions]]
			*[[PCC]]

	==References==		==References==