Ipecac toxicity - Revision history

Ostermayer: Prepared the page for translation

2026-01-04T23:14:08Z

Prepared the page for translation

← Older revision		Revision as of 23:14, 4 January 2026
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			<languages/>
			<translate>

	==Background==		==Background==

	*Rapidly acting emetic agent		*Rapidly acting emetic agent
	*Derived from the ipecacuanha plant		*Derived from the ipecacuanha plant
	*Often abused by adults with eating disorders		*Often abused by adults with eating disorders
	*Occasionally seen used in Munchausen by proxy		*Occasionally seen used in Munchausen by proxy


	===Mechanism of Action===		===Mechanism of Action===
	*[[Vomiting]]
			*[[Special:MyLanguage/Vomiting\|Vomiting]]
	**Immediate: direct irritation of gastric mucosa		**Immediate: direct irritation of gastric mucosa
	**Delayed: absorption, stimulation of chemoreceptor trigger zone		**Delayed: absorption, stimulation of chemoreceptor trigger zone
	*Inhibition of protein synthesis in skeletal muscle		*Inhibition of protein synthesis in skeletal muscle


	===Toxic Dose===		===Toxic Dose===

	*Acute		*Acute
	**As little as 10 mL of the potent fluid extract can cause death		**As little as 10 mL of the potent fluid extract can cause death
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	**Slow elimination of emetine causes cumulative toxicity		**Slow elimination of emetine causes cumulative toxicity
	**Daily ingestion of 90-120 mL of syrup for several months can cause cardiomyopathy and death		**Daily ingestion of 90-120 mL of syrup for several months can cause cardiomyopathy and death


	==Clinical Features==		==Clinical Features==


	===Acute===		===Acute===
	*[[Nausea/vomiting]]
	*[[Gastritis]]		*[[Special:MyLanguage/Nausea/vomiting\|Nausea/vomiting]]
			*[[Special:MyLanguage/Gastritis\|Gastritis]]

	===Chronic===		===Chronic===
	*[[Dehydration]]
	*[[Diarrhea]]		*[[Special:MyLanguage/Dehydration\|Dehydration]]
	*[[Hypokalemia]]		*[[Special:MyLanguage/Diarrhea\|Diarrhea]]
	*[[Cardiomyopathy]]		*[[Special:MyLanguage/Hypokalemia\|Hypokalemia]]
	*Myopathy ([[weakness]], hyporeflexia)		*[[Special:MyLanguage/Cardiomyopathy\|Cardiomyopathy]]
			*Myopathy ([[Special:MyLanguage/weakness\|weakness]], hyporeflexia)


	==Differential Diagnosis==		==Differential Diagnosis==

			</translate>
	{{Nausea and vomiting DDX}}		{{Nausea and vomiting DDX}}
			<translate>


	==Evaluation==		==Evaluation==

	*Emetine can be detected in urine for several weeks		*Emetine can be detected in urine for several weeks
	*Electrolytes, CPK, LDH		*Electrolytes, CPK, LDH
	*[[ECG]]		*[[Special:MyLanguage/ECG\|ECG]]


	==Management==		==Management==

	*No specific antidote exists		*No specific antidote exists
	*Supportive care is mainstay of treatment		*Supportive care is mainstay of treatment
	**[[IV fluids]]		**[[Special:MyLanguage/IV fluids\|IV fluids]]
	**[[Electrolyte repletion]]		**[[Special:MyLanguage/Electrolyte repletion\|Electrolyte repletion]]


	==Disposition==		==Disposition==
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	==References==		==References==

	<references/>		<references/>

	[[Category:Toxicology]]		[[Category:Toxicology]]
	[[Category:GI]]		[[Category:GI]]
			</translate>

ClaireLewis at 21:46, 29 September 2019

2019-09-29T21:46:30Z

← Older revision		Revision as of 21:46, 29 September 2019
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	===Acute===		===Acute===
	*[[Nausea/vomiting]]		*[[Nausea/vomiting]]
	*Gastritis		*[[Gastritis]]
	===Chronic===		===Chronic===
	*[[Dehydration]]		*[[Dehydration]]
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	*No specific antidote exists		*No specific antidote exists
	*Supportive care is mainstay of treatment		*Supportive care is mainstay of treatment
	**IV fluids		**[[IV fluids]]
	**Electrolyte repletion		**[[Electrolyte repletion]]

	==Disposition==		==Disposition==

Mholtz at 16:08, 17 November 2017

2017-11-17T16:08:44Z

← Older revision		Revision as of 16:08, 17 November 2017
Line 31:		Line 31:

	==Differential Diagnosis==		==Differential Diagnosis==
			{{Nausea and vomiting DDX}}

	==Evaluation==		==Evaluation==

Mholtz at 16:07, 17 November 2017

2017-11-17T16:07:54Z

← Older revision		Revision as of 16:07, 17 November 2017
Line 5:		Line 5:
	*Occasionally seen used in Munchausen by proxy		*Occasionally seen used in Munchausen by proxy

	==Mechanism of Action==		===Mechanism of Action===
	*[[Vomiting]]		*[[Vomiting]]
	**Immediate: direct irritation of gastric mucosa		**Immediate: direct irritation of gastric mucosa
Line 11:		Line 11:
	*Inhibition of protein synthesis in skeletal muscle		*Inhibition of protein synthesis in skeletal muscle

	==Toxic Dose==		===Toxic Dose===
	*Acute		*Acute
	**As little as 10 mL of the potent fluid extract can cause death		**As little as 10 mL of the potent fluid extract can cause death
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	===Acute===		===Acute===
	*[[Nausea/vomiting]]		*[[Nausea/vomiting]]
	**Gastritis		*Gastritis
	~~[[Mallory-Weiss]] tears~~
	*Gastric rupture (rare)
	===Chronic===		===Chronic===
	*[[Dehydration]]		*[[Dehydration]]
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	*[[Cardiomyopathy]]		*[[Cardiomyopathy]]
	*Myopathy ([[weakness]], hyporeflexia)		*Myopathy ([[weakness]], hyporeflexia)

			==Differential Diagnosis==


	==Evaluation==		==Evaluation==
	*Emetine can be detected in urine for several weeks		*Emetine can be detected in urine for several weeks
	*Electrolytes~~, BUN/Cr~~, CPK, LDH		*Electrolytes, CPK, LDH
	*[[ECG]]		*[[ECG]]

	==Management==		==Management==
	*~~Administer activated charcoal~~		*No specific antidote exists
	*IV fluids ~~as needed~~		*Supportive care is mainstay of treatment
	*~~Potassium~~ repletion ~~as needed~~		**IV fluids
	*Diuretics/pressors for cardiomyopathy and CHF		**Electrolyte repletion
	*No specific antidote
			==Disposition==


			==See Also==


			==External Links==


	==References==		==References==
	*Olson, K. Poisoning and Drug Overdose Clinical Manual. 2004		<references/>

	[[Category:Toxicology]] [[Category:GI]]		[[Category:Toxicology]]
			[[Category:GI]]

Mholtz: Mholtz moved page Ipecac to Ipecac toxicity

2017-11-03T10:07:33Z

Mholtz moved page Ipecac to Ipecac toxicity

← Older revision	Revision as of 10:07, 3 November 2017
(No difference)

ClaireLewis: /* Chronic */

2016-12-22T20:08:42Z

Chronic

← Older revision		Revision as of 20:08, 22 December 2016
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	*[[Dehydration]]		*[[Dehydration]]
	*[[Diarrhea]]		*[[Diarrhea]]
	*[[Hypokalemia		*[[Hypokalemia]]
	*[[Cardiomyopathy		*[[Cardiomyopathy]]
	*Myopathy ([[weakness]]], hyporeflexia)		*Myopathy ([[weakness]], hyporeflexia)

	==Evaluation==		==Evaluation==

ClaireLewis at 02:25, 11 December 2016

2016-12-11T02:25:08Z

← Older revision		Revision as of 02:25, 11 December 2016
Line 46:		Line 46:
	==References==		==References==
	*Olson, K. Poisoning and Drug Overdose Clinical Manual. 2004		*Olson, K. Poisoning and Drug Overdose Clinical Manual. 2004

			[[Category:Toxicology]] [[Category:GI]]

ClaireLewis at 01:43, 11 December 2016

2016-12-11T01:43:28Z

← Older revision		Revision as of 01:43, 11 December 2016
Line 6:		Line 6:

	==Mechanism of Action==		==Mechanism of Action==
	*Vomiting		*[[Vomiting]]
	**Immediate: direct irritation of gastric mucosa		**Immediate: direct irritation of gastric mucosa
	**Delayed: absorption, stimulation of chemoreceptor trigger zone		**Delayed: absorption, stimulation of chemoreceptor trigger zone
Line 20:		Line 20:

	==Clinical Features==		==Clinical Features==
	*Acute		===Acute===
	**Nausea, vomiting~~, gastritis,~~ Mallory-Weiss tears~~, and gastric~~ rupture (rare)		*[[Nausea/vomiting]]
	*~~Chronic~~		**Gastritis
	**~~Dehydration, hypokalemia, diarrhea, cardiomyopathy, myopathy~~ (weakness, hyporeflexia)		[[Mallory-Weiss]] tears
			*Gastric rupture (rare)
			===Chronic===
			*[[Dehydration]]
			*[[Diarrhea]]
			*[[Hypokalemia
			*[[Cardiomyopathy
			*Myopathy ([[weakness]]], hyporeflexia)

	==Evaluation==		==Evaluation==
	*Emetine can be detected in urine for several weeks		*Emetine can be detected in urine for several weeks
	*Electrolytes, BUN/Cr, CPK, LDH, ECG		*Electrolytes, BUN/Cr, CPK, LDH
			*[[ECG]]

	==Management==		==Management==

Bisakson: /* Toxic Dose */

2016-12-09T05:46:05Z

Toxic Dose

← Older revision		Revision as of 05:46, 9 December 2016
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	*Chronic		*Chronic
	**Slow elimination of emetine causes cumulative toxicity		**Slow elimination of emetine causes cumulative toxicity
	**Daily ingestion of 90-120 mL of syrup can cause cardiomyopathy and death		**Daily ingestion of 90-120 mL of syrup for several months can cause cardiomyopathy and death

	==Clinical Features==		==Clinical Features==

Bisakson: Created page with "==Background== Rapidly acting emetic agent Derived from the ipecacuanha plant Often abused by adults with eating disorders Occasionally seen used in Munchausen by proxy =..."

2016-12-09T05:45:30Z

Created page with "==Background== *Rapidly acting emetic agent *Derived from the ipecacuanha plant *Often abused by adults with eating disorders *Occasionally seen used in Munchausen by proxy =..."

New page

==Background==
*Rapidly acting emetic agent
*Derived from the ipecacuanha plant
*Often abused by adults with eating disorders
*Occasionally seen used in Munchausen by proxy

==Mechanism of Action==
*Vomiting
**Immediate: direct irritation of gastric mucosa
**Delayed: absorption, stimulation of chemoreceptor trigger zone
*Inhibition of protein synthesis in skeletal muscle

==Toxic Dose==
*Acute
**As little as 10 mL of the potent fluid extract can cause death
**120 mL of syrup of ipecac unlikely to cause severe toxicity
*Chronic
**Slow elimination of emetine causes cumulative toxicity
**Daily ingestion of 90-120 mL of syrup can cause cardiomyopathy and death

==Clinical Features==
*Acute
**Nausea, vomiting, gastritis, Mallory-Weiss tears, and gastric rupture (rare)
*Chronic
**Dehydration, hypokalemia, diarrhea, cardiomyopathy, myopathy (weakness, hyporeflexia)

==Evaluation==
*Emetine can be detected in urine for several weeks
*Electrolytes, BUN/Cr, CPK, LDH, ECG

==Management==
*Administer activated charcoal
*IV fluids as needed
*Potassium repletion as needed
*Diuretics/pressors for cardiomyopathy and CHF
*No specific antidote

==References==
*Olson, K. Poisoning and Drug Overdose Clinical Manual. 2004