Jimson weed - Revision history

Danbot: Add MedicationDose entries for physostigmine

2026-03-20T21:17:41Z

Add MedicationDose entries for physostigmine

@@ Line 39: / Line 39: @@
 **Children should receive 0.02 mg/kg intravenously and the rate should not exceed 0.5 mg/min
 **Note that [[pyridostigmine]] does not cross the blood brain barrier, and is a poor agent for agitation, CNS features
 ==See Also==

2024-03-27T22:03:08Z

← Older revision		Revision as of 22:03, 27 March 2024
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	*Inhalation (smoking dried leaves or other plant parts)		*Inhalation (smoking dried leaves or other plant parts)
	*Ingestion (eating plant parts or foods containing extracts)		*Ingestion (eating plant parts or foods containing extracts)

	~~{{Anticholinergic types}}~~

	==Clinical Features==		==Clinical Features==

2024-03-27T22:01:29Z

Background

← Older revision		Revision as of 22:01, 27 March 2024
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	*Inhalation (smoking dried leaves or other plant parts)		*Inhalation (smoking dried leaves or other plant parts)
	*Ingestion (eating plant parts or foods containing extracts)		*Ingestion (eating plant parts or foods containing extracts)

			{{Anticholinergic types}}

	==Clinical Features==		==Clinical Features==

2019-01-27T02:43:49Z

Background

← Older revision		Revision as of 02:43, 27 January 2019
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	[[File:Jimson_weed.png\|thumb\|Datura stramonium aka Jimson Weed]]		[[File:Jimson_weed.png\|thumb\|Datura stramonium aka Jimson Weed]]
	*Contains up to 28 different anticholinergic alkaloids<ref>Krenzelok EP. Aspects of Datura poisoning and treatment. Clin Tox. 2010; 48(2):104-110.</ref>		*Contains up to 28 different anticholinergic alkaloids<ref>Krenzelok EP. Aspects of Datura poisoning and treatment. Clin Tox. 2010; 48(2):104-110.</ref>
	**[[Atropine]], hyoscyamine, and [[scopolamine]]		**[[Atropine]], [[hyoscyamine]], and [[scopolamine]]
	*All parts of the plant are toxic but the highest concentration is in the seeds		*All parts of the plant are toxic but the highest concentration is in the seeds
	**50-100 seeds in each pod		**50-100 seeds in each pod

2018-10-13T20:04:56Z

Management

← Older revision		Revision as of 20:04, 13 October 2018
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	**A second dose may be administered if necessary		**A second dose may be administered if necessary
	**Children should receive 0.02 mg/kg intravenously and the rate should not exceed 0.5 mg/min		**Children should receive 0.02 mg/kg intravenously and the rate should not exceed 0.5 mg/min

	**Note that [[pyridostigmine]] does not cross the blood brain barrier, and is a poor agent for agitation, CNS features		**Note that [[pyridostigmine]] does not cross the blood brain barrier, and is a poor agent for agitation, CNS features

2018-10-13T20:04:46Z

Management

← Older revision		Revision as of 20:04, 13 October 2018
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	*Supportive care and patient reassurance		*Supportive care and patient reassurance
	*Sedation as needed with benzos		*Sedation as needed with benzos
	*In severe cases, physostigmine 0.5–2.~~0mg~~ IV at a rate of no more than 1mg/min (adult dosing)		*In severe cases, [[physostigmine]] 0.5–2.0 mg IV at a rate of no more than 1mg/min (adult dosing)
	**A second dose may be administered if necessary		**A second dose may be administered if necessary
	**Children should receive 0.~~02mg~~/kg intravenously and the rate should not exceed 0.~~5mg~~/min		**Children should receive 0.02 mg/kg intravenously and the rate should not exceed 0.5 mg/min

			**Note that [[pyridostigmine]] does not cross the blood brain barrier, and is a poor agent for agitation, CNS features

	==See Also==		==See Also==

2017-04-03T15:20:34Z

Background

← Older revision		Revision as of 15:20, 3 April 2017
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	[[File:Jimson_weed.png\|thumb\|Datura stramonium aka Jimson Weed]]		[[File:Jimson_weed.png\|thumb\|Datura stramonium aka Jimson Weed]]
	*Contains up to 28 different anticholinergic alkaloids<ref>Krenzelok EP. Aspects of Datura poisoning and treatment. Clin Tox. 2010; 48(2):104-110.</ref>		*Contains up to 28 different anticholinergic alkaloids<ref>Krenzelok EP. Aspects of Datura poisoning and treatment. Clin Tox. 2010; 48(2):104-110.</ref>
	**Atropine, hyoscyamine, and scopolamine		**[[Atropine]], hyoscyamine, and [[scopolamine]]
	*All parts of the plant are toxic but the highest concentration is in the seeds		*All parts of the plant are toxic but the highest concentration is in the seeds
	**50-100 seeds in each pod		**50-100 seeds in each pod

2016-07-22T21:26:37Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 21:26, 22 July 2016
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	{{Anticholinergic types}}		{{Anticholinergic types}}

	==~~Diagnosis~~==		==Evaluation==
	Clinical diagnosis with history and physical exam		Clinical diagnosis with history and physical exam
	{{Clinical Features Anticholinergic Toxicity}}		{{Clinical Features Anticholinergic Toxicity}}

2016-07-20T08:51:28Z

Text replacement - "6 mg" to "6mg"

← Older revision		Revision as of 08:51, 20 July 2016
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	*All parts of the plant are toxic but the highest concentration is in the seeds		*All parts of the plant are toxic but the highest concentration is in the seeds
	**50-100 seeds in each pod		**50-100 seeds in each pod
	**100 seeds is the equivalent of about ~~6 mg~~ atropine		**100 seeds is the equivalent of about 6mg atropine
	*Estimated lethal doses of atropine in adults ≥10mg<ref>Shervette RE, et al. Jimson "loco" weed abuse in adolescents. Pediatrics. 1979; 63:520-523.</ref>		*Estimated lethal doses of atropine in adults ≥10mg<ref>Shervette RE, et al. Jimson "loco" weed abuse in adolescents. Pediatrics. 1979; 63:520-523.</ref>

2016-07-20T04:21:12Z

Text replacement - "2 mg" to "2mg"

← Older revision		Revision as of 04:21, 20 July 2016
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	*In severe cases, physostigmine 0.5–2.0mg IV at a rate of no more than 1mg/min (adult dosing)		*In severe cases, physostigmine 0.5–2.0mg IV at a rate of no more than 1mg/min (adult dosing)
	**A second dose may be administered if necessary		**A second dose may be administered if necessary
	**Children should receive 0.~~02 mg~~/kg intravenously and the rate should not exceed 0.5mg/min		**Children should receive 0.02mg/kg intravenously and the rate should not exceed 0.5mg/min

	==See Also==		==See Also==