Lisinopril - Revision history

Kxl328: /* Adult Dosing */

2025-04-22T16:59:01Z

Adult Dosing

← Older revision		Revision as of 16:59, 22 April 2025
Line 11:		Line 11:
	==Adult Dosing==		==Adult Dosing==
	*Hypertension: 10 - 40mg PO Qday, max 80mg/day		*Hypertension: 10 - 40mg PO Qday, max 80mg/day
	*Occasionally outpatient will prescribe BID dosing of lisinopril for potential continuous BP control(or [[losartan]])		*Occasionally outpatient will prescribe BID dosing of lisinopril for potential continuous BP control (or [[losartan]])
	**2020 large scale Kaiser study concluded no increased efficacy		**2020 large scale Kaiser study concluded no increased efficacy
	**There is potential for risk for AKI and hyperkalemia with lisinopril, but not losartan -- hypotension was not investigated<ref>Derington et al. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020 Dec 3;15(12):e0243371. doi: 10.1371/journal.pone.0243371</ref>		**There is potential for risk for AKI and hyperkalemia with lisinopril, but not losartan -- hypotension was not investigated<ref>Derington et al. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020 Dec 3;15(12):e0243371. doi: 10.1371/journal.pone.0243371</ref>

2025-04-22T16:58:47Z

Adult Dosing

← Older revision		Revision as of 16:58, 22 April 2025
Line 10:		Line 10:

	==Adult Dosing==		==Adult Dosing==
	*~~hypertension~~: 10 - 40mg PO Qday, max 80mg/day		*Hypertension: 10 - 40mg PO Qday, max 80mg/day
			*Occasionally outpatient will prescribe BID dosing of lisinopril for potential continuous BP control(or [[losartan]])
			**2020 large scale Kaiser study concluded no increased efficacy
			**There is potential for risk for AKI and hyperkalemia with lisinopril, but not losartan -- hypotension was not investigated<ref>Derington et al. Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety. PLoS One. 2020 Dec 3;15(12):e0243371. doi: 10.1371/journal.pone.0243371</ref>

	==Pediatric Dosing==		==Pediatric Dosing==

2021-03-08T16:01:47Z

General

← Older revision		Revision as of 16:01, 8 March 2021
Line 1:		Line 1:
	==General==		==General==
	*Type: [[ACE inhibitor]]		*Type: [[ACE inhibitor]]
	*Dosage Forms: 2.5, 5, 10, 20, 30, 40		*Dosage Forms: 2.5mg, 5mg, 10mg, 20mg, 30mg, 40mg
	*Common Trade Names: Prinivil, Zestril		*Common Trade Names: Prinivil, Zestril

2021-03-08T16:01:09Z

2019-09-22T22:56:14Z

References

2017-07-13T06:46:34Z

2016-08-11T06:42:52Z

Text replacement - "Cr " to "creatinine "

← Older revision		Revision as of 06:42, 11 August 2016
Line 20:		Line 20:
	*Renal Dosing		*Renal Dosing
	**Adult: CrCl < 30, start 2.5mg qday, max 40mg q/day		**Adult: CrCl < 30, start 2.5mg qday, max 40mg q/day
	**Pediatric Cr Cl 30-50: decrease dose 50%, CrCl < 30, avoid use		**Pediatric creatinine Cl 30-50: decrease dose 50%, CrCl < 30, avoid use
	*Hepatic Dosing		*Hepatic Dosing
	**Adult: Not defined		**Adult: Not defined

2016-07-31T08:42:30Z

Text replacement - "HTN" to "hypertension"

← Older revision		Revision as of 08:42, 31 July 2016
Line 10:		Line 10:

	==Adult Dosing==		==Adult Dosing==
	*~~HTN~~: 10 - 40mg PO Qday, max 80mg/day		*hypertension: 10 - 40mg PO Qday, max 80mg/day

	==Pediatric Dosing==		==Pediatric Dosing==

2016-07-21T10:09:07Z

Text replacement - "5 mg" to "5mg"

← Older revision		Revision as of 10:09, 21 July 2016
Line 19:		Line 19:
	*Lactation: Safety unknown		*Lactation: Safety unknown
	*Renal Dosing		*Renal Dosing
	**Adult: CrCl < 30, start 2.~~5 mg~~ qday, max 40mg q/day		**Adult: CrCl < 30, start 2.5mg qday, max 40mg q/day
	**Pediatric Cr Cl 30-50: decrease dose 50%, CrCl < 30, avoid use		**Pediatric Cr Cl 30-50: decrease dose 50%, CrCl < 30, avoid use
	*Hepatic Dosing		*Hepatic Dosing

2016-07-19T18:48:38Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 18:48, 19 July 2016
Line 5:		Line 5:

	General information:		General information:
	*Doses > ~~40 mg~~/day rarely more effective		*Doses > 40mg/day rarely more effective
	*Decreased efficacy as mono therapy in Black patients		*Decreased efficacy as mono therapy in Black patients
	*Obtain Chem 10 if starting in ED to assess renal function		*Obtain Chem 10 if starting in ED to assess renal function

	==Adult Dosing==		==Adult Dosing==
	*HTN: 10 - ~~40 mg~~ PO Qday, max ~~80 mg~~/day		*HTN: 10 - 40mg PO Qday, max 80mg/day

	==Pediatric Dosing==		==Pediatric Dosing==
	*6-16 year old: 0.07mg/kg PO qday, max ~~40 mg~~/day		*6-16 year old: 0.07mg/kg PO qday, max 40mg/day

	==Special Populations==		==Special Populations==
Line 19:		Line 19:
	*Lactation: Safety unknown		*Lactation: Safety unknown
	*Renal Dosing		*Renal Dosing
	**Adult: CrCl < 30, start 2.5 mg qday, max ~~40 mg~~ q/day		**Adult: CrCl < 30, start 2.5 mg qday, max 40mg q/day
	**Pediatric Cr Cl 30-50: decrease dose 50%, CrCl < 30, avoid use		**Pediatric Cr Cl 30-50: decrease dose 50%, CrCl < 30, avoid use
	*Hepatic Dosing		*Hepatic Dosing