Metformin-associated lactic acidosis - Revision history

Danbot: Add evidence-based Disposition section

2026-03-22T10:03:12Z

Add evidence-based Disposition section

@@ Line 49: / Line 49: @@
 ***Renal insufficiency
 **Mortality benefits mainly from improving acidosis than from removing Metformin
 ==See Also==

Elcatracho: /* Evaluation */

2021-03-07T23:41:24Z

Evaluation

← Older revision		Revision as of 23:41, 7 March 2021
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	==Evaluation==		==Evaluation==
	*FS		*FS
	*[ASA]		*[[ASA]]
	*[APAP]		*[[APAP]]
	*[[ECG]]		*[[ECG]]
	*bHCG		*bHCG

Elcatracho: /* Background */

2021-03-07T23:40:49Z

Background

← Older revision		Revision as of 23:40, 7 March 2021
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	==Background==		==Background==
	*Acute and chronic use of [[metformin]] can lead to rare complication of Metformin-~~associate~~ lactic acidosis (MALA)		*Acute and chronic use of [[metformin]] can lead to rare complication of Metformin-associated [[lactic acidosis]] (MALA)
	*Excreted (unmetabolized) in proximal tubules		*Excreted (unmetabolized) in proximal tubules
	*Stimulates anaerobic glucose metabolism in splanchnic bed → increased lactate production		*Stimulates anaerobic glucose metabolism in splanchnic bed → increased lactate production

Rossdonaldson1: Text replacement - "ECG" to "ECG"

2016-09-09T13:11:05Z

Text replacement - "*ECG" to "*ECG"

← Older revision		Revision as of 13:11, 9 September 2016
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	*[ASA]		*[ASA]
	*[APAP]		*[APAP]
	*ECG		*[[ECG]]
	*bHCG		*bHCG
	*ABG		*ABG

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-24T01:35:58Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 01:35, 24 July 2016
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	{{Lactic acidosis DDX}}		{{Lactic acidosis DDX}}

	==~~Diagnosis~~==		==Evaluation==
	*FS		*FS
	*[ASA]		*[ASA]

ClaireLewis: /* Management */

2016-07-14T00:27:57Z

Management

← Older revision		Revision as of 00:27, 14 July 2016
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	==Management==		==Management==
	*If intubated, maintain minute ventilation so as to not remove respiratory compensation for acidosis		*If intubated, maintain minute ventilation so as to not remove respiratory compensation for acidosis
	*Activated charcoal if peri-ingestion/MS appropriate		*Activated charcoal if peri-ingestion/mental status appropriate
	*Metformin should not cause hypoglycemia and, if present, should lead to work up of cause		*Metformin should not cause hypoglycemia and, if present, should lead to work up of cause
	*Sodium Bicarbonate		*Sodium Bicarbonate

ClaireLewis: /* Clinical Features */

2016-07-14T00:27:18Z

Clinical Features

← Older revision		Revision as of 00:27, 14 July 2016
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	==Clinical Features==		==Clinical Features==
	*Nausea		*Nausea
	*Vomiting		*[[Vomiting]]
	*Diarrhea		*[[Diarrhea]]
	*Altered mental status		*[[Altered mental status]]
	*Dyspnea		*[[Dyspnea]]
	*Hypotension		*[[Hypotension]]
	*Tachycardia		*[[Tachycardia]]
	*Tachypnea		*Tachypnea

ClaireLewis: /* Background */

2016-07-14T00:26:36Z