Neuroblastoma (peds) - Revision history

Rossdonaldson1: /* Evaluation */

2022-04-23T11:17:52Z

Evaluation

← Older revision		Revision as of 11:17, 23 April 2022
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	==Evaluation==		==Evaluation==
			[[File:PMC4769609 gr2.png\|thumb\|Abdominal CT demonstrating (A) a heterogeneously enhancing mass in the pancreatic body and tail with (B) encasement of the celiac axis.]]
			[[File:PMC4206056 jrip-3-79-g001.png\|thumb\|Neuroblastoma accompanied by hyperaldosteronism.]]
	*Catecholamines; VMA and HVA of serum and urine		*Catecholamines; VMA and HVA of serum and urine
	*CT or MRI		*CT or MRI

Rossdonaldson1 at 11:17, 23 April 2022

2022-04-23T11:17:29Z

← Older revision		Revision as of 11:17, 23 April 2022
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	==Background==		==Background==
			[[File:PMC4112030 40064 2013 1059 Fig3 HTML.png\|thumb\|Neuroblastoma: (a) Abdominal CT-scan: large heterogeneous right abdominal mass with a tumor thrombus of the inferior vena (Arrow). (b) Gross examination of the tumor: heterogeneous partially necrotizing tumor of the right adrenal gland. (c):Histology of the tumor: neuroblastoma poorly differentiated.]]
	*Arises from primitive ganglion cells of sympathetic nervous system		*Arises from primitive ganglion cells of sympathetic nervous system
	*Synthesize and secrete catecholamines		*Synthesize and secrete catecholamines

Rossdonaldson1 at 11:16, 23 April 2022

2022-04-23T11:16:01Z

← Older revision		Revision as of 11:16, 23 April 2022
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	==Management==		==Management==
			*No acute treatment

			==Disposition==
	*Admission for tumor biopsy and further workup		*Admission for tumor biopsy and further workup

	==See Also==		==See Also==

			==External Links==

	==References==		==References==

Rossdonaldson1: /* Evaluation */

2022-04-23T11:14:59Z

Evaluation

← Older revision		Revision as of 11:14, 23 April 2022
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	*Catecholamines; VMA and HVA of serum and urine		*Catecholamines; VMA and HVA of serum and urine
	*CT or MRI		*CT or MRI
	**Although US is often the initial radiologic study of choice for abdominal mass, ~~you need to look at the~~ primary tumor site and possible nodes on CT or MRI		**Although US is often the initial radiologic study of choice for abdominal mass, primary tumor site and possible nodes on are better evaluated on CT or MRI
	*[[CXR]]		*[[CXR]]
	*Biopsy for definitive diagnosis		*Biopsy for definitive diagnosis

Rossdonaldson1 at 11:14, 23 April 2022

2022-04-23T11:14:25Z

← Older revision		Revision as of 11:14, 23 April 2022
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	==Background==		==Background==
	[[File:PMC4112030 40064 2013 1059 Fig3 HTML.png\|thumb\|Neuroblastoma: (a) Abdominal CT-scan: large heterogeneous right abdominal mass with a tumor thrombus of the inferior vena (Arrow). (b) Gross examination of the tumor: heterogeneous partially necrotizing tumor of the right adrenal gland. (c):Histology of the tumor: neuroblastoma poorly differentiated.]]
	*Arises from primitive ganglion cells of sympathetic nervous system		*Arises from primitive ganglion cells of sympathetic nervous system
	*Synthesize and secrete catecholamines		*Synthesize and secrete catecholamines
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	*Depends on location		*Depends on location
	**Abdominal mass		**Abdominal mass
	***2/3 of primary neuroblastoma arise in the abdomen		***2/3 of primary neuroblastoma arise in the abdomen<ref>https://www.uptodate.com/contents/clinical-presentation-diagnosis-and-staging-evaluation-of-neuroblastoma?search=neuroblastoma%20children&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1</ref>
	**Abdominal pain or constipation		**Abdominal pain or constipation
	**Proptosis or periorbital ecchymoses		**Proptosis or periorbital ecchymoses
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	==Evaluation==		==Evaluation==
	~~[[File:PMC4769609 gr2.png\|thumb\|Abdominal CT demonstrating (A) a heterogeneously enhancing mass in the pancreatic body and tail with (B) encasement of the celiac axis.]]~~
	~~[[File:PMC4206056 jrip-3-79-g001.png\|thumb\|Neuroblastoma accompanied by hyperaldosteronism.]]~~
	*Catecholamines; VMA and HVA of serum and urine		*Catecholamines; VMA and HVA of serum and urine
	*CT or MRI		*CT or MRI
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	[[Category:Pediatrics]]		[[Category:Pediatrics]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
	[https://www.uptodate.com/contents/clinical-presentation-diagnosis-and-staging-evaluation-of-neuroblastoma?search=neuroblastoma%20children&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1]

Rossdonaldson1: /* Background */

2022-04-23T11:12:21Z

Background

← Older revision		Revision as of 11:12, 23 April 2022
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	==Background==		==Background==
			[[File:PMC4112030 40064 2013 1059 Fig3 HTML.png\|thumb\|Neuroblastoma: (a) Abdominal CT-scan: large heterogeneous right abdominal mass with a tumor thrombus of the inferior vena (Arrow). (b) Gross examination of the tumor: heterogeneous partially necrotizing tumor of the right adrenal gland. (c):Histology of the tumor: neuroblastoma poorly differentiated.]]
	*Arises from primitive ganglion cells of sympathetic nervous system		*Arises from primitive ganglion cells of sympathetic nervous system
	*Synthesize and secrete catecholamines		*Synthesize and secrete catecholamines

Rossdonaldson1: /* Evaluation */

2022-04-23T11:10:19Z

Evaluation

← Older revision		Revision as of 11:10, 23 April 2022
Line 31:		Line 31:
	==Evaluation==		==Evaluation==
	[[File:PMC4769609 gr2.png\|thumb\|Abdominal CT demonstrating (A) a heterogeneously enhancing mass in the pancreatic body and tail with (B) encasement of the celiac axis.]]		[[File:PMC4769609 gr2.png\|thumb\|Abdominal CT demonstrating (A) a heterogeneously enhancing mass in the pancreatic body and tail with (B) encasement of the celiac axis.]]
			[[File:PMC4206056 jrip-3-79-g001.png\|thumb\|Neuroblastoma accompanied by hyperaldosteronism.]]
	*Catecholamines; VMA and HVA of serum and urine		*Catecholamines; VMA and HVA of serum and urine
	*CT or MRI		*CT or MRI

Rossdonaldson1: /* Evaluation */

2022-04-23T11:08:56Z

Evaluation

← Older revision		Revision as of 11:08, 23 April 2022
Line 30:		Line 30:

	==Evaluation==		==Evaluation==
			[[File:PMC4769609 gr2.png\|thumb\|Abdominal CT demonstrating (A) a heterogeneously enhancing mass in the pancreatic body and tail with (B) encasement of the celiac axis.]]
	*Catecholamines; VMA and HVA of serum and urine		*Catecholamines; VMA and HVA of serum and urine
	*CT or MRI		*CT or MRI

SMReel: /* Clinical Features */

2022-04-18T21:53:10Z

Clinical Features

← Older revision		Revision as of 21:53, 18 April 2022
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	**Abdominal pain or constipation		**Abdominal pain or constipation
	**Proptosis or periorbital ecchymoses		**Proptosis or periorbital ecchymoses
	**[[Horner syndrome]]: ~~mitosis~~, ptosis, anhidrosis		**[[Horner syndrome]]: miosis, ptosis, anhidrosis
	**Paraspinal mass		**Paraspinal mass
	**Spinal cord compression, which can cause localized back pain or weakness		**Spinal cord compression, which can cause localized back pain or weakness

SMReel: /* Background */

2022-04-15T15:10:24Z

Background

← Older revision		Revision as of 15:10, 15 April 2022
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	==Background==		==Background==
	*Arises from primitive ganglion cells of sympathetic nervous system		*Arises from primitive ganglion cells of sympathetic nervous system
			*Synthesize and secrete catecholamines
	*Most common neoplasm in 1st yr of life		*Most common neoplasm in 1st yr of life
	*May arise anywhere along sympathetic nervous system		*May arise anywhere along sympathetic nervous system
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	**Abdomen (25%)		**Abdomen (25%)
	**Chest (15%)		**Chest (15%)
			*Mets are most common in lymph nodes, bone marrow, cortical bone, dura, orbits, liver, and skin

	==Clinical Features==		==Clinical Features==
	*Depends on location		*Depends on location
	**~~Large, painless abdominal~~ mass		**Abdominal mass
	**~~Compression~~ of ~~bowel/bladder~~		***2/3 of primary neuroblastoma arise in the abdomen
	**[[Horner syndrome]]		**Abdominal pain or constipation
	**Spinal cord compression		**Proptosis or periorbital ecchymoses
	*[[Opsoclonus]]-myoclonus		**[[Horner syndrome]]: mitosis, ptosis, anhidrosis
			**Paraspinal mass
			**Spinal cord compression, which can cause localized back pain or weakness
			**Systemic symptoms, bone pain, anemia
			*[[Opsoclonus]]-myoclonus: rapid, dancing eye movements, rhythmic jerking of trunk or limbs, and/or ataxia
	**[[paraneoplastic]] syndrome highly associated with neuroblastoma		**[[paraneoplastic]] syndrome highly associated with neuroblastoma
	*[[Neutropenia]]/[[pancytopenia]] suggests bone marrow involvement		*[[Neutropenia]]/[[pancytopenia]] suggests bone marrow involvement
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	==Differential Diagnosis==		==Differential Diagnosis==
	*[[Wilms' tumor]]		*[[Wilms' tumor]]
			*Hepatoblastoma
			*Lymphoma
	*Other adrenal gland tumor		*Other adrenal gland tumor

	==Evaluation==		==Evaluation==
			*Catecholamines; VMA and HVA of serum and urine
	*CT or MRI		*CT or MRI
			**Although US is often the initial radiologic study of choice for abdominal mass, you need to look at the primary tumor site and possible nodes on CT or MRI
	*[[CXR]]		*[[CXR]]
	*Biopsy for definitive diagnosis		*Biopsy for definitive diagnosis

	==Management==		==Management==
	*Admission for tumor biopsy		*Admission for tumor biopsy and further workup

	==See Also==		==See Also==
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	[[Category:Pediatrics]]		[[Category:Pediatrics]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
			[https://www.uptodate.com/contents/clinical-presentation-diagnosis-and-staging-evaluation-of-neuroblastoma?search=neuroblastoma%20children&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1]