Oxygen toxicity - Revision history

DMartinPAC: /* Background */

2025-10-31T16:41:51Z

Background

← Older revision		Revision as of 16:41, 31 October 2025
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	**Partial pressure of O2 at sea level = 0.21 ATM		**Partial pressure of O2 at sea level = 0.21 ATM
	*Toxicity based on both time of exposure and partial pressure of oxygen		*Toxicity based on both time of exposure and partial pressure of oxygen
	**Generally, FiO2 of 40% or less (0.40 ATM) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>		**Generally, FiO2 of 40% or less (0.40 ATM at sea level, breathing unpressurized air) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>
	**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen		**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen
	**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />		**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />

Rossdonaldson1: /* Central nervous system */

2020-07-18T13:15:23Z

Central nervous system

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	===Central nervous system===		===Central nervous system===
	*[[visual disturbances\|Tunnel vision]]		*[[visual disturbances\|Tunnel vision]]
	*[[Tinnitus[[		*[[Tinnitus]]
	*[[Nausea]]		*[[Nausea]]
	*Facial twitching		*Facial twitching

Rossdonaldson1: /* Background */

2020-07-18T13:15:10Z

Background

← Older revision		Revision as of 13:15, 18 July 2020
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	**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen		**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen
	**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />		**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />

			{{Diving Physiology}}

	==Clinical Features==		==Clinical Features==

ClaireLewis at 21:38, 28 September 2019

2019-09-28T21:38:08Z

← Older revision		Revision as of 21:38, 28 September 2019
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	==Clinical Features==		==Clinical Features==
	===Pulmonary===		===Pulmonary===
	*Tracheobronchial irritation (initial manifestation) → pleuritic chest pain, dyspnea and ~~coughing~~<ref name="Thomson">Thomson L, Paton J. Oxygen toxicity. Paediatr Respir Rev. 2014 Jun;15(2):120-3.</ref><ref name="Bitterman">Bitterman H. Bench-to-bedside review: Oxygen as a drug. Critical Care. 2009;13(1):205. doi:10.1186/cc7151.</ref>		*Tracheobronchial irritation (initial manifestation) → pleuritic [[chest pain]], [[dyspnea]] and [[cough]]ing<ref name="Thomson">Thomson L, Paton J. Oxygen toxicity. Paediatr Respir Rev. 2014 Jun;15(2):120-3.</ref><ref name="Bitterman">Bitterman H. Bench-to-bedside review: Oxygen as a drug. Critical Care. 2009;13(1):205. doi:10.1186/cc7151.</ref>
	*Atelectasis		*Atelectasis
	*Diffuse alveolar damage → [[Pulmonary edema]]/[[ARDS]]		*Diffuse alveolar damage → [[Pulmonary edema]]/[[ARDS]]

	===Central nervous system===		===Central nervous system===
	*Tunnel vision		*[[visual disturbances\|Tunnel vision]]
	*Tinnitus		*[[Tinnitus[[
	*[[Nausea]]		*[[Nausea]]
	*Facial twitching		*Facial twitching
	*Irritability (personality changes, anxiety, confusion, etc.)		*Irritability (personality changes, anxiety, [[confusion]], etc.)
	*[[Seizure]]		*[[Seizure]]

	===Ocular===		===Ocular===
	*Retinopathy of prematurity (~~retrolentar~~ fibroplasia) - seen in premature infants		*Retinopathy of prematurity (retrolental fibroplasia) - seen in premature infants
	*Hyperoxic myopia - seen in adults exposed to repeated toxic levels of oxygen<ref>Anderson B, Farmer JC. Hyperoxic myopia. Transactions of the American Ophthalmological Society. 1978;76:116-124.</ref>		*Hyperoxic myopia - seen in adults exposed to repeated toxic levels of oxygen<ref>Anderson B, Farmer JC. Hyperoxic myopia. Transactions of the American Ophthalmological Society. 1978;76:116-124.</ref>
	**Resolves spontaneously over several weeks		**Resolves spontaneously over several weeks

Mholtz at 00:28, 1 January 2017

2017-01-01T00:28:11Z

← Older revision		Revision as of 00:28, 1 January 2017
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	==Background==		==Background==
	*The harmful effects of breathing oxygen at higher partial pressures than normal		*The harmful effects of breathing oxygen at higher partial pressures than normal
	**Partial pressure of O2 at sea level = 0.21 ~~ATA~~		**Partial pressure of O2 at sea level = 0.21 ATM
	*Toxicity based on both time and partial pressure of oxygen		*Toxicity based on both time of exposure and partial pressure of oxygen
	**Generally, FiO2 of 40% or less (0.40 ~~ATA~~) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>		**Generally, FiO2 of 40% or less (0.40 ATM) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>
	**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen		**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen
	**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />		**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />
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	==Evaluation==		==Evaluation==
	*~~Clinical diagnosis~~		*Generally clinical

	==Management==		==Management==
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	==External Links==		==External Links==


	==References==		==References==

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-24T11:26:05Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

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	{{Scuba diving DDX}}		{{Scuba diving DDX}}

	==~~Diagnosis~~==		==Evaluation==
	*Clinical diagnosis		*Clinical diagnosis

Ostermayer: Text replacement - "Category:Environ" to "Category:Environmental"

2016-03-22T14:47:02Z

Text replacement - "Category:Environ" to "Category:Environmental"

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	<references/>		<references/>

	[[Category:~~Environ~~]]		[[Category:Environmental]]

Mholtz at 06:18, 5 March 2016

2016-03-05T06:18:21Z

← Older revision		Revision as of 06:18, 5 March 2016
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	*Toxicity based on both time and partial pressure of oxygen		*Toxicity based on both time and partial pressure of oxygen
	**Generally, FiO2 of 40% or less (0.40 ATA) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>		**Generally, FiO2 of 40% or less (0.40 ATA) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>
	**Most common in hyperbaric oxygen therapy and prolonged administration of normobaric supplemental oxygen		**Most common in hyperbaric oxygen therapy, scuba divers and prolonged administration of normobaric supplemental oxygen
	**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />		**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />

Mholtz at 04:10, 5 March 2016

2016-03-05T04:10:56Z

← Older revision		Revision as of 04:10, 5 March 2016
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	===Ocular===		===Ocular===
	*Retinopathy of prematurity (retrolentar fibroplasia)		*Retinopathy of prematurity (retrolentar fibroplasia) - seen in premature infants
	**Seen in premature infants		*Hyperoxic myopia - seen in adults exposed to repeated toxic levels of oxygen<ref>Anderson B, Farmer JC. Hyperoxic myopia. Transactions of the American Ophthalmological Society. 1978;76:116-124.</ref>
	*In adults exposed to repeated toxic levels of oxygen~~, can get hyperoxic myopia~~<ref>Anderson B, Farmer JC. Hyperoxic myopia. Transactions of the American Ophthalmological Society. 1978;76:116-124.</ref>
	**Resolves spontaneously over several weeks		**Resolves spontaneously over several weeks

Mholtz at 04:09, 5 March 2016

2016-03-05T04:09:46Z

← Older revision		Revision as of 04:09, 5 March 2016
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	**Generally, FiO2 of 40% or less (0.40 ATA) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>		**Generally, FiO2 of 40% or less (0.40 ATA) can be tolerated indefinitely<ref name="Hedley">Hedley-Whyte J. Pulmonary Oxygen Toxicity: Investigation and Mentoring. The Ulster Medical Journal. 2008;77(1):39-42.</ref>
	**Most common in hyperbaric oxygen therapy and prolonged administration of normobaric supplemental oxygen		**Most common in hyperbaric oxygen therapy and prolonged administration of normobaric supplemental oxygen
	**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />		**Pulmonary toxicity occurs sooner and at lower partial pressures than CNS toxicity<ref name="Hedley" />, however there is no predictable pattern or sequence of symptoms for CNS toxicity (initial symptom may be seizure/coma)<ref name="Bitterman" />

	==Clinical Features==		==Clinical Features==
	===Pulmonary===		===Pulmonary===
	*Tracheobronchial irritation → pleuritic chest pain, dyspnea and coughing<ref name="Thomson">Thomson L, Paton J. Oxygen toxicity. Paediatr Respir Rev. 2014 Jun;15(2):120-3.</ref>		*Tracheobronchial irritation (initial manifestation) → pleuritic chest pain, dyspnea and coughing<ref name="Thomson">Thomson L, Paton J. Oxygen toxicity. Paediatr Respir Rev. 2014 Jun;15(2):120-3.</ref><ref name="Bitterman">Bitterman H. Bench-to-bedside review: Oxygen as a drug. Critical Care. 2009;13(1):205. doi:10.1186/cc7151.</ref>
	*Atelectasis		*Atelectasis
	*Diffuse alveolar damage → [[Pulmonary edema]]/[[ARDS]]		*Diffuse alveolar damage → [[Pulmonary edema]]/[[ARDS]]