Ostermayer at 00:23, 28 January 2026

2026-01-28T00:23:36Z

← Older revision		Revision as of 00:23, 28 January 2026
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	==Adult Dosing==		==Adult Dosing==
	~~===General===~~
	*Determine indication (Gout vs Adjuvant)

	===Hyperuricemia ([[Gout]])===		===Hyperuricemia ([[Gout]])===
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	*Given concurrently with [[Cefoxitin]] 2g IM x 1		*Given concurrently with [[Cefoxitin]] 2g IM x 1

	===Neurosyphilis (Adjunct)===		===[[Neurosyphilis]] (Adjunct)===
	*500mg PO q6h		*500mg PO q6h
	*Given concurrently with Procaine [[Penicillin]] G 2.4 million units IM daily x 10-14 days		*Given concurrently with Procaine [[Penicillin]] G 2.4 million units IM daily x 10-14 days

Ostermayer: Created page with "==General== Type: Is DrugClass::Uricosuric Agent Is DrugClass::Antibiotic Adjuvant Dosage Forms: Tablet Dosage Strengths: 500mg Routes of Administration: PO Common Trade Names: Benemid, Probalan ==Adult Dosing== ===General=== Determine indication (Gout vs Adjuvant) ===Hyperuricemia (Gout)=== Start: 250mg PO bid x 1 week Maintenance: 500mg PO bid May increase by 500mg/day q4weeks if not controlled Max: 2g/day ===Pelvic Inflammatory Disease (PID)..."

2026-01-27T18:03:45Z

Created page with "==General== *Type: Is DrugClass::Uricosuric Agent Is DrugClass::Antibiotic Adjuvant *Dosage Forms: Tablet *Dosage Strengths: 500mg *Routes of Administration: PO *Common Trade Names: Benemid, Probalan ==Adult Dosing== ===General=== *Determine indication (Gout vs Adjuvant) ===Hyperuricemia (Gout)=== *Start: 250mg PO bid x 1 week *Maintenance: 500mg PO bid *May increase by 500mg/day q4weeks if not controlled *Max: 2g/day ===Pelvic Inflammatory Disease (PID)..."

New page

==General==
*Type: [[Is DrugClass::Uricosuric Agent]] [[Is DrugClass::Antibiotic Adjuvant]]
*Dosage Forms: Tablet
*Dosage Strengths: 500mg
*Routes of Administration: PO
*Common Trade Names: Benemid, Probalan

==Adult Dosing==
===General===
*Determine indication (Gout vs Adjuvant)

===Hyperuricemia ([[Gout]])===
*Start: 250mg PO bid x 1 week
*Maintenance: 500mg PO bid
*May increase by 500mg/day q4weeks if not controlled
*Max: 2g/day

===[[Pelvic Inflammatory Disease (PID)]]===
*1g PO x 1
*Given concurrently with [[Cefoxitin]] 2g IM x 1

===Neurosyphilis (Adjunct)===
*500mg PO q6h
*Given concurrently with Procaine [[Penicillin]] G 2.4 million units IM daily x 10-14 days

==Pediatric Dosing==
===General (< 2 years)===
*Contraindicated

===General (2 - 14 years)===
*Adjunct to antibiotic therapy (limited data/use)
*Initial: 25mg/kg PO x 1
*Maintenance: 40mg/kg/day divided q6h

==Special Populations==
*Pregnancy: B
*Lactation: Excreted in breast milk; safety not established
*Renal
**Adult
***CrCl <30: Avoid use (likely ineffective for uricosuric effect; may typically be used for simple antibiotic adjuvant effect if necessary, but risk of toxicity increases)
**Pediatric
***Not defined
*Hepatic
**No specific guidelines defined, but metabolized by liver

==Contraindications==
*Allergy to Probenecid
*Children < 2 years of age
*Concomitant use with ketorolac (increases ketorolac plasma levels significantly)
*Concomitant use with salicylates (aspirin antagonizes uricosuric action)
*Uric acid lithiasis (kidney stones)
*Acute [[Gout]] attack (do not initiate therapy during acute attack)
*Blood dyscrasias
*[[G6PD Deficiency]] (risk of hemolytic anemia)

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
*Hemolytic [[Anemia]] (associated with G6PD deficiency)
*Aplastic Anemia
*Hepatic Necrosis
*Nephrotic Syndrome
*[[Seizures]]

===Common===
*[[Headache]]
*[[Nausea and Vomiting]]
*Anorexia
*Dizziness
*Flushing
*[[Rash]] (Urticaria/Pruritus)
*Gingival soreness
*Urinary frequency

==Pharmacology==
*Half-life: 3-8h (dose dependent)
*Metabolism: Liver
*Excretion: Urine
*Mechanism of Action:
**Uricosuric: Inhibits tubular reabsorption of urate, increasing urinary excretion of uric acid.
**Adjuvant: Inhibits renal tubular secretion of beta-lactam antibiotics (penicillins, cephalosporins), thereby increasing their plasma concentrations and half-life.

==See Also==
*[[Gout]]
*[[Pelvic Inflammatory Disease (PID)]]
*[[Syphilis]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Probenecid - Revision history

Ostermayer at 00:23, 28 January 2026