Scurvy - Revision history

Rossdonaldson1: /* Background */

2024-12-11T18:13:55Z

Background

← Older revision		Revision as of 18:13, 11 December 2024
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	==Background==		==Background==
			{{Skin anatomy background images}}
	*Nutritional deficiency of Vitamin C (Ascorbic acid)		*Nutritional deficiency of Vitamin C (Ascorbic acid)
	*Vitamin C is typically found in fruits and vegetables.		*Vitamin C is typically found in fruits and vegetables.

Rossdonaldson1: /* Clinical FeaturesPichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44. */

2021-09-25T10:14:14Z

Clinical FeaturesPichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.

← Older revision		Revision as of 10:14, 25 September 2021
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	*Isolated elderly persons with poor nutrition		*Isolated elderly persons with poor nutrition

	==Clinical Features~~<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>~~==		==Clinical Features==
	[[File:Corkscrew hair.png\|thumb\|Corkscrew hair in a patient with scurvy.]]		[[File:Corkscrew hair.png\|thumb\|Corkscrew hair in a patient with scurvy.]]
	[[File:Petechiae.png\|thumb\|Petechiae in a patient with scurvy.]]		[[File:Petechiae.png\|thumb\|Petechiae in a patient with scurvy.]]
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	*Perifollicular hemmorrhage		*Perifollicular hemmorrhage
	*Weakness, fatigue, and muscle cramping		*Weakness, fatigue, and muscle cramping
	**Vitamin C is cofactor for enzymes involved in biosynthesis of carnitine, which is essential for release of energy via transport of fatty acids into mitochondria		**Vitamin C is cofactor for enzymes involved in biosynthesis of carnitine, which is essential for release of energy via transport of fatty acids into mitochondria<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>
	*Mood disturbance, cognitive impairment, delusions and depression		*Mood disturbance, cognitive impairment, delusions and depression<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>
	**Vitamin C is a modulator of neurotransmitter synthesis and release (e.g. Dopamine)		**Vitamin C is a modulator of neurotransmitter synthesis and release (e.g. Dopamine)<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>
	*Anemia		*Anemia
	**Vit C promotes intestinal absorption of Iron and prevents oxidative damage to the red-cell cytoskeleton		**Vit C promotes intestinal absorption of Iron and prevents oxidative damage to the red-cell cytoskeleton<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: /* Background */

2021-09-25T10:13:32Z

Background

← Older revision		Revision as of 10:13, 25 September 2021
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	*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.		*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.
	*16th-19th century sailors with scurvy found to have developed tooth decay, bruising, lassitude, and often died from massive hemorrhage<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>		*16th-19th century sailors with scurvy found to have developed tooth decay, bruising, lassitude, and often died from massive hemorrhage<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>
	*Groups at risk:
	**Eating disorders or select eating habits		===Risk Factors===
	**Infants who only consume pasteurized milk		*Eating disorders or select eating habits
	**Autism		*Infants who only consume pasteurized milk
	**Alcohol disorder		*Autism
	**Isolated elderly persons with poor nutrition		*Alcohol disorder
			*Isolated elderly persons with poor nutrition

	==Clinical Features<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>==		==Clinical Features<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>==

Jonrako at 02:40, 19 September 2021

2021-09-19T02:40:25Z

← Older revision		Revision as of 02:40, 19 September 2021
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	*Depends on the manifestations of vitamin C and their severity		*Depends on the manifestations of vitamin C and their severity

	~~==See Also==~~

	==External Links==		==External Links==

Jonrako at 02:39, 19 September 2021

2021-09-19T02:39:20Z

← Older revision		Revision as of 02:39, 19 September 2021
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	**Isolated elderly persons with poor nutrition		**Isolated elderly persons with poor nutrition

	==Clinical Features==		==Clinical Features<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>==
	[[File:Corkscrew hair.png\|thumb\|Corkscrew hair in a patient with scurvy.]]		[[File:Corkscrew hair.png\|thumb\|Corkscrew hair in a patient with scurvy.]]
	[[File:Petechiae.png\|thumb\|Petechiae in a patient with scurvy.]]		[[File:Petechiae.png\|thumb\|Petechiae in a patient with scurvy.]]
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	*Corkscrew hair		*Corkscrew hair
	*Perifollicular hemmorrhage		*Perifollicular hemmorrhage
			*Weakness, fatigue, and muscle cramping
			**Vitamin C is cofactor for enzymes involved in biosynthesis of carnitine, which is essential for release of energy via transport of fatty acids into mitochondria
			*Mood disturbance, cognitive impairment, delusions and depression
			**Vitamin C is a modulator of neurotransmitter synthesis and release (e.g. Dopamine)
			*Anemia
			**Vit C promotes intestinal absorption of Iron and prevents oxidative damage to the red-cell cytoskeleton

	==Differential Diagnosis==		==Differential Diagnosis==
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	==Management==		==Management==
	*Vitamin C supplementation.		*Vitamin C supplementation.
			**1 gram of oral vitamin C daily

	==Disposition==		==Disposition==
			*Depends on the manifestations of vitamin C and their severity

	==See Also==		==See Also==

Jonrako: /* Background */

2021-09-19T02:26:31Z

Background

← Older revision		Revision as of 02:26, 19 September 2021
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	*Groups at risk:		*Groups at risk:
	**Eating disorders or select eating habits		**Eating disorders or select eating habits
	**~~infants~~ who only consume pasteurized milk		**Infants who only consume pasteurized milk
	**Autism		**Autism
	**Alcohol disorder		**Alcohol disorder
	**~~isolated~~ elderly persons with poor nutrition		**Isolated elderly persons with poor nutrition

	==Clinical Features==		==Clinical Features==

Jonrako: /* Background */

2021-09-19T02:25:40Z

Background

← Older revision		Revision as of 02:25, 19 September 2021
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	***Easy bruising		***Easy bruising
	*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.		*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.
			*16th-19th century sailors with scurvy found to have developed tooth decay, bruising, lassitude, and often died from massive hemorrhage<ref>Pichan, Cayla, B. S., et al. “Inadequate Support.” New England Journal of Medicine, vol. 385, no. 10, 2021, pp. 938–44.</ref>
			*Groups at risk:
			**Eating disorders or select eating habits
			**infants who only consume pasteurized milk
			**Autism
			**Alcohol disorder
			**isolated elderly persons with poor nutrition

	==Clinical Features==		==Clinical Features==

Elcatracho: /* Clinical Features */

2021-02-23T19:09:30Z

Clinical Features

← Older revision		Revision as of 19:09, 23 February 2021
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	*[[Petechiae]]		*[[Petechiae]]
	*Corkscrew hair		*Corkscrew hair
			*Perifollicular hemmorrhage

	==Differential Diagnosis==		==Differential Diagnosis==

Elcatracho: /* Background */

2021-02-23T19:08:51Z

Background

← Older revision		Revision as of 19:08, 23 February 2021
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	*Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix.		*Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix.
	*Scurvy therefore leads to unstable collagen and collagen fragility.		*Scurvy therefore leads to unstable collagen and collagen fragility.
	**~~leaking~~ of vascular structures		**Leaking of vascular structures
	***~~gingival~~ bleeding		***Gingival bleeding
	***~~petechiae~~		***[[Petechiae]]
	***~~easy~~ bruising		***Easy bruising
	*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.		*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.

Taleesha: /* Background */

2017-08-24T21:19:10Z

Background

← Older revision		Revision as of 21:19, 24 August 2017
Line 1:		Line 1:
	==Background==		==Background==
	*Nutritional deficiency of Vitamin C (Ascorbic acid)		*Nutritional deficiency of Vitamin C (Ascorbic acid)
	*Vitamin C is typically ~~foundin~~ fruits and vegetables.		*Vitamin C is typically found in fruits and vegetables.
	*Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix.		*Vitamin C is a cofactor for hydroxylation of proline and lysine amino acids in procollagen molecules, which is required for cross-linking collagen's triple helix.
	*Scurvy therefore leads to unstable collagen and collagen fragility.		*Scurvy therefore leads to unstable collagen and collagen fragility.
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	***petechiae		***petechiae
	***easy bruising		***easy bruising
	*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.		*Vitamin C is also required for the disulfide bonding in hair leading to corkscrew appearance of hair.

	==Clinical Features==		==Clinical Features==