Serum sickness - Revision history

Elcatracho: /* External Links */

2022-01-10T18:38:23Z

External Links

← Older revision		Revision as of 18:38, 10 January 2022
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	==External Links==		==External Links==
			*[http://pemcincinnati.com/blog/briefs-serum-sickness-like-reaction-re-post/ Cincinnati PEM Blog Briefs: Serum Sickness]

	==See Also==		==See Also==

Elcatracho: /* Background */

2022-01-10T18:36:50Z

Background

← Older revision		Revision as of 18:36, 10 January 2022
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	==Background==		==Background==
			[[File:Serum_sickness.jpeg\|thumb\|Typical appearance of serum sickness rash]]
	*A type III [[Hypersensitivity Reaction\|hypersensitivity reaction]] (secondary to injection of anitoxins e.g. [[tetanus]], [[rabies]])		*A type III [[Hypersensitivity Reaction\|hypersensitivity reaction]] (secondary to injection of anitoxins e.g. [[tetanus]], [[rabies]])
	*Reactions secondary to the administration of nonprotein drugs (e.g. [[Amoxicillin]], [[cefaclor]], [[cephalexin]] (Keflex), [[trimethoprim-sulfamethoxazole]])		*Reactions secondary to the administration of nonprotein drugs (e.g. [[Amoxicillin]], [[cefaclor]], [[cephalexin]] (Keflex), [[trimethoprim-sulfamethoxazole]])

ClaireLewis: /* Evaluation */

2019-10-16T17:37:33Z

Evaluation

← Older revision		Revision as of 17:37, 16 October 2019
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	*Mild [[leukopenia]] or [[leukocytosis]]		*Mild [[leukopenia]] or [[leukocytosis]]
	*ESR elevation		*ESR elevation
	*Mild proteinuria		*Mild [[proteinuria]]
	*Mild [[hematuria]]		*Mild [[hematuria]]
	*Mild serum creatinine elevation		*Mild serum creatinine elevation

ClaireLewis at 01:35, 28 September 2019

2019-09-28T01:35:53Z

← Older revision		Revision as of 01:35, 28 September 2019
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	*[[Polymyositis]]		*[[Polymyositis]]
	*[[Systemic Lupus Erythematosus]]		*[[Systemic Lupus Erythematosus]]
	*Tick~~-Borne Diseases~~, [[Rocky Mountain Spotted Fever]]		*[[Tick borne illnesses]], [[Rocky Mountain Spotted Fever]]
	*[[Toxic Epidermal Necrolysis]]		*[[Toxic Epidermal Necrolysis]]

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	**Careful investigation of new medications		**Careful investigation of new medications
	**[http://emedicine.medscape.com/article/332032-overview#a5 List] of serum sickness medications		**[http://emedicine.medscape.com/article/332032-overview#a5 List] of serum sickness medications
	*Mild leukopenia or leukocytosis		*Mild [[leukopenia]] or [[leukocytosis]]
	*ESR elevation		*ESR elevation
	*Mild proteinuria		*Mild proteinuria
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	*Other labs to obtain:		*Other labs to obtain:
	**CH50		**CH50
	**LFTs		**[[LFTs]]
	**Urine electrolytes (Na, K, Cr, eosinophils)		**Urine electrolytes (Na, K, Cr, eosinophils)
	**ESR and CRP		**ESR and CRP
	**~~HepB, HepC~~ panel, HIV, RPR/VDRL		**[[Viral hepatitis]] panel, HIV, RPR/VDRL

	==Management==		==Management==

ClaireLewis: /* Clinical Features */

2019-09-19T17:03:50Z

Clinical Features

← Older revision		Revision as of 17:03, 19 September 2019
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	==Clinical Features==		==Clinical Features==
	*[[Fever]]		*[[Fever]]
	*Arthralgia		*[[Arthralgia]]
	*Lymphadenopathy		*[[Lymphadenopathy]]
	*Skin eruption (rash)		*Skin eruption (rash)
	**[[Urticaria]]		**[[Urticaria]]
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	**Maculopapular or purpuric lesions		**Maculopapular or purpuric lesions
	**[[Erythema multiforme]]		**[[Erythema multiforme]]

	==Differential Diagnosis==		==Differential Diagnosis==
	*[[Erythema multiforme]]		*[[Erythema multiforme]]

Mholtz at 00:41, 25 May 2018

2018-05-25T00:41:24Z

← Older revision		Revision as of 00:41, 25 May 2018
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	==Background==		==Background==
	*A type III [[Hypersensitivity Reaction\|hypersensitivity reaction]]		*A type III [[Hypersensitivity Reaction\|hypersensitivity reaction]] (secondary to injection of anitoxins e.g. [[tetanus]], [[rabies]])
	**Secondary to injection of anitoxins (e.g. [[tetanus]], [[rabies]])		*Reactions secondary to the administration of nonprotein drugs (e.g. [[Amoxicillin]], [[cefaclor]], [[cephalexin]] (Keflex), [[trimethoprim-sulfamethoxazole]])
	*Reactions secondary to the administration of nonprotein drugs		*Primary occurs 6-21 days after initial exposure
	**[[Amoxicillin]], [[cefaclor]], [[cephalexin]] (Keflex), [[trimethoprim-sulfamethoxazole]]		**1-4 days after subsequent exposures to the same antigen
			*Symptoms usually last 1-2 weeks before spontaneously subsiding
			*Long-lasting sequelae generally do not occur
			*Fatalities are rare and usually are due to continued administration of the antigen

	==Clinical Features==		==Clinical Features==
	*Primary occurs 6-21 days after exposure
	**1-4 days after subsequent exposures to the same antigen
	*[[Fever]]		*[[Fever]]
	*Arthralgia		*Arthralgia
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	*Clinical diagnosis in which labs may be suggestive but not required<ref>Alissa HM et al. Serum Sickness Workup. Dec 14, 2015. http://emedicine.medscape.com/article/332032-workup#showall</ref>		*Clinical diagnosis in which labs may be suggestive but not required<ref>Alissa HM et al. Serum Sickness Workup. Dec 14, 2015. http://emedicine.medscape.com/article/332032-workup#showall</ref>
	**Careful investigation of new medications		**Careful investigation of new medications
	**[http://emedicine.medscape.com/article/332032-overview#a5 List] of serum sickness medications ~~extensive~~		**[http://emedicine.medscape.com/article/332032-overview#a5 List] of serum sickness medications
	*Mild leukopenia or leukocytosis		*Mild leukopenia or leukocytosis
	*ESR elevation		*ESR elevation
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	==Disposition==		==Disposition==
	Admit for:		*Admit for:
	*Significant comorbidities (advanced or very young age, immunocompromised)		**Significant comorbidities (advanced or very young age, immunocompromised)
	*Severe symptoms		**Severe symptoms
	*Hemodynamic instability/hypotension		**Hemodynamic instability/hypotension
	*Unclear diagnosis		**Unclear diagnosis

			==External Links==


			==See Also==

	~~==Prognosis==~~
	*Symptoms usually last 1-2 weeks before spontaneously subsiding
	*Long-lasting sequelae generally do not occur
	*Fatalities are rare and usually are due to continued administration of the antigen

	==References==		==References==
	<references/>		<references/>

	[[Category:Dermatology]]		[[Category:Dermatology]]
			[[Category:Rheumatology]]

Josgood: /* Management */

2018-05-22T05:57:29Z

Management

← Older revision		Revision as of 05:57, 22 May 2018
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	*Discontinue antigen		*Discontinue antigen
	*Antipyretics		*Antipyretics
	*[[~~Diphenhydramamine~~]]		*[[Diphenhydramine]]
	*[[Prednisone]]		*[[Prednisone]]

Neil.m.young: Text replacement - "Cr " to "creatinine "

2016-08-11T07:15:02Z

Text replacement - "Cr " to "creatinine "

← Older revision		Revision as of 07:15, 11 August 2016
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	*Mild proteinuria		*Mild proteinuria
	*Mild [[hematuria]]		*Mild [[hematuria]]
	*Mild serum Cr elevation		*Mild serum creatinine elevation
	*Decreased C3, C4		*Decreased C3, C4
	*Other labs to obtain:		*Other labs to obtain:

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-25T15:25:02Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 15:25, 25 July 2016
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	{{Differential Diagnosis Polyarthritis}}		{{Differential Diagnosis Polyarthritis}}

	==~~Diagnosis~~==		==Evaluation==
	*Clinical diagnosis in which labs may be suggestive but not required<ref>Alissa HM et al. Serum Sickness Workup. Dec 14, 2015. http://emedicine.medscape.com/article/332032-workup#showall</ref>		*Clinical diagnosis in which labs may be suggestive but not required<ref>Alissa HM et al. Serum Sickness Workup. Dec 14, 2015. http://emedicine.medscape.com/article/332032-workup#showall</ref>
	**Careful investigation of new medications		**Careful investigation of new medications

Neil.m.young: Text replacement - "==Treatment==" to "==Management=="

2016-07-09T22:50:13Z

Text replacement - "==Treatment==" to "==Management=="

← Older revision		Revision as of 22:50, 9 July 2016
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	**HepB, HepC panel, HIV, RPR/VDRL		**HepB, HepC panel, HIV, RPR/VDRL

	==~~Treatment~~==		==Management==
	*Discontinue antigen		*Discontinue antigen
	*Antipyretics		*Antipyretics