Sildenafil - Revision history

Jonwarren: /* Contraindications */

2018-03-08T18:47:01Z

Contraindications

← Older revision		Revision as of 18:47, 8 March 2018
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	*Dosage Forms:		*Dosage Forms:
	*Routes of Administration: PO, IV		*Routes of Administration: PO, IV
	*Common Trade Names: Viagra, Revatio		*Common Trade Names: Viagra, [https://fildena.net Fildena], Revatio

	==Adult Dosing==		==Adult Dosing==
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	*Concurrent regular or intermittent use of any organic nitrates		*Concurrent regular or intermittent use of any organic nitrates
	*Concomitant use with HIV protease inhibitors or elvitegravir/cobicistat/tenofovir/emtricitabine		*Concomitant use with HIV protease inhibitors or elvitegravir/cobicistat/tenofovir/emtricitabine
	*Concomitant use with riociguat or any other guanylate cyclase stimulator		*Concomitant use with [[riociguat]] or any other guanylate cyclase stimulator

	==Adverse Reactions==		==Adverse Reactions==

Mholtz: Text replacement - "-->" to "→"

2017-11-18T10:16:26Z

Text replacement - "-->" to "→"

← Older revision		Revision as of 10:16, 18 November 2017
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	==Mechanism of Action==		==Mechanism of Action==
	*Inhibits cGMP specific phosphodiesterase type-5 (PDE5) in smooth ~~muscle-->~~ less cGMP ~~breakdown-->~~ more cGMP within vascular smooth ~~muscle-->~~ vascular smooth muscle ~~relaxation-->~~ vasodilation		*Inhibits cGMP specific phosphodiesterase type-5 (PDE5) in smooth muscle→ less cGMP breakdown→ more cGMP within vascular smooth muscle→ vascular smooth muscle relaxation→ vasodilation

	==Comments==		==Comments==

ClaireLewis: Created page with "==Administration== Type: PDE-5 inhibitor Dosage Forms: Routes of Administration: PO, IV Common Trade Names: Viagra, Revatio ==Adult Dosing== *Pulmonary hypertension: 5-20..."

2017-08-22T14:34:41Z

Created page with "==Administration== *Type: PDE-5 inhibitor *Dosage Forms: *Routes of Administration: PO, IV *Common Trade Names: Viagra, Revatio ==Adult Dosing== *Pulmonary hypertension: 5-20..."

New page

==Administration==
*Type: PDE-5 inhibitor
*Dosage Forms:
*Routes of Administration: PO, IV
*Common Trade Names: Viagra, Revatio

==Adult Dosing==
*Pulmonary hypertension: 5-20mg PO TID or 2.5-10 mg IV bolus TID
*Erectile dysfunction: 25-100mg PO 1hr prior to sexual activity, max once daily

==Pediatric Dosing==
''Not generally recommended for chronic use in pediatric patients, but is used off-label''

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: B
*Lactation risk: Infant risk cannot be ruled out
*Renal dosing: no adjustment
*Hepatic dosing: no adjustment for mild-moderate impairment

==Contraindications==
*Allergy to class/drug
*Concurrent regular or intermittent use of any organic nitrates
*Concomitant use with HIV protease inhibitors or elvitegravir/cobicistat/tenofovir/emtricitabine
*Concomitant use with riociguat or any other guanylate cyclase stimulator

==Adverse Reactions==
===Serious===
*Myocardial infaction
*Sickle cell vasoocclusive crisis
*Ischemic optic neuropathy, retinal hemorrhage
*Hearing loss
*Priapism
===Common===
*Headache
*Insomnia
*Visual disturbance
*Erythema, flushing
*Indigestion
*Epistaxis, nasal congestion, rhinorrhea

==Pharmacology==
*Half-life: 4h
*Metabolism: Hepatic: CYP3A4 (major) and CYP2C9 (minor)
*Excretion: Mostly fecal

==Mechanism of Action==
*Inhibits cGMP specific phosphodiesterase type-5 (PDE5) in smooth muscle--> less cGMP breakdown--> more cGMP within vascular smooth muscle--> vascular smooth muscle relaxation--> vasodilation

==Comments==

==See Also==
*[[Pulmonary hypertension]]

==References==
<references/>

[[Category:Pharmacology]]

Sildenafil - Revision history

Jonwarren: /* Contraindications */

Mholtz: Text replacement - "-->" to "→"

ClaireLewis: Created page with "==Administration== *Type: PDE-5 inhibitor *Dosage Forms: *Routes of Administration: PO, IV *Common Trade Names: Viagra, Revatio ==Adult Dosing== *Pulmonary hypertension: 5-20..."

ClaireLewis: Created page with "==Administration== Type: PDE-5 inhibitor Dosage Forms: Routes of Administration: PO, IV Common Trade Names: Viagra, Revatio ==Adult Dosing== *Pulmonary hypertension: 5-20..."