Splenic sequestration - Revision history

Ostermayer: Prepared the page for translation

2026-01-04T23:59:14Z

Prepared the page for translation

← Older revision		Revision as of 23:59, 4 January 2026
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			<languages/>
			<translate>

	==Background==		==Background==
	*Leading cause of pediatric mortality related to [[sickle cell disease]]<ref>Brousse V et al. Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 pediatric patients. British Journal of Haematology. 2012;156:643-648.</ref>
			*Leading cause of pediatric mortality related to [[Special:MyLanguage/sickle cell disease\|sickle cell disease]]<ref>Brousse V et al. Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 pediatric patients. British Journal of Haematology. 2012;156:643-648.</ref>
	*More common in pediatric patients as many adults with SCD have autoinfarcted their spleen		*More common in pediatric patients as many adults with SCD have autoinfarcted their spleen
	*Earliest life threatening complication of SCD with median age 1-4<sup>3</sup>		*Earliest life threatening complication of SCD with median age 1-4<sup>3</sup>
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	***Some resources differentiate between major and minor episodes depending on the hgb drop		***Some resources differentiate between major and minor episodes depending on the hgb drop
	*Lifelong prevalence 7-30%<sup>3</sup>		*Lifelong prevalence 7-30%<sup>3</sup>
	*Often precipitated by underlying infection ([[pneumonia]], [[gastroenteritis]])		*Often precipitated by underlying infection ([[Special:MyLanguage/pneumonia\|pneumonia]], [[Special:MyLanguage/gastroenteritis\|gastroenteritis]])


	==Clinical Features==		==Clinical Features==
	*[[Abdominal pain]]
	*[[Fatigue]]		*[[Special:MyLanguage/Abdominal pain\|Abdominal pain]]
			*[[Special:MyLanguage/Fatigue\|Fatigue]]
	*Pallor		*Pallor
	*[[Tachycardia]]		*[[Special:MyLanguage/Tachycardia\|Tachycardia]]
	*[[Anemia]]		*[[Special:MyLanguage/Anemia\|Anemia]]
	*[[Hypotension]]		*[[Special:MyLanguage/Hypotension\|Hypotension]]
	*Circulatory collapse		*Circulatory collapse
	*Splenomegaly		*Splenomegaly


	==Differential Diagnosis==		==Differential Diagnosis==

			</translate>
	{{Sickle cell DDX}}		{{Sickle cell DDX}}
			<translate>


	==Evaluation==		==Evaluation==

	[[File:PMC4800468 10.1177 2324709616638363-fig1.png\|thumb\|CT abdomen demonstrating enlarged spleen consistent with acute splenic sequestration crisis.]]		[[File:PMC4800468 10.1177 2324709616638363-fig1.png\|thumb\|CT abdomen demonstrating enlarged spleen consistent with acute splenic sequestration crisis.]]

	===Workup===		===Workup===

	*Labs		*Labs
	**CBC		**CBC
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	**Reticulocyte count		**Reticulocyte count
	**LFTs		**LFTs
	**[[Blood cultures]]		**[[Special:MyLanguage/Blood cultures\|Blood cultures]]


	===Diagnosis===		===Diagnosis===

	*Imaging not necessary to make diagnosis		*Imaging not necessary to make diagnosis


	==Management==		==Management==

	*Pain control		*Pain control
	*IV fluid resuscitation and blood transfusion<ref>Abboud MR. Standard management of sickle cell disease complications. Hematology/Oncology and Stem Cell Therapy. 2020;3(1):85-90.		*IV fluid resuscitation and blood transfusion<ref>Abboud MR. Standard management of sickle cell disease complications. Hematology/Oncology and Stem Cell Therapy. 2020;3(1):85-90.
	</ref>		</ref>
	**Caution with IVF if anemia is severe		**Caution with IVF if anemia is severe
	**Goal Hct 35% to avoid [[hyperviscosity syndrome]]<sup>3</sup>		**Goal Hct 35% to avoid [[Special:MyLanguage/hyperviscosity syndrome\|hyperviscosity syndrome]]<sup>3</sup>
	*Treat underlying cause if found - infection common		*Treat underlying cause if found - infection common
	*Possible splenectomy		*Possible splenectomy
	**Recurrence rate is 50-75%<sup>1,2,3</sup><ref>Kane I, Nagalli S. Splenic Sequestration Crisis. [Updated 2020 Jul 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553164/</ref>		**Recurrence rate is 50-75%<sup>1,2,3</sup><ref>Kane I, Nagalli S. Splenic Sequestration Crisis. [Updated 2020 Jul 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553164/</ref>
	*Hematology consultation		*Hematology consultation


	==Disposition==		==Disposition==

	*Admission		*Admission


	==Complications==		==Complications==
	*[[Shock]]
	*[[Splenic infarct]]		*[[Special:MyLanguage/Shock\|Shock]]
	*[[Splenic rupture]]		*[[Special:MyLanguage/Splenic infarct\|Splenic infarct]]
	*[[Sepsis]]		*[[Special:MyLanguage/Splenic rupture\|Splenic rupture]]
			*[[Special:MyLanguage/Sepsis\|Sepsis]]


	==See Also==		==See Also==
	*[[Sickle cell crisis]]
			*[[Special:MyLanguage/Sickle cell crisis\|Sickle cell crisis]]


	==External Links==		==External Links==
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	==References==		==References==

	<references/>		<references/>
	[[Category:GI]]		[[Category:GI]]
	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]
			</translate>

Rossdonaldson1: /* Workup */

2020-08-12T19:59:03Z

Workup

← Older revision		Revision as of 19:59, 12 August 2020
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	**Reticulocyte count		**Reticulocyte count
	**LFTs		**LFTs
	**Blood cultures		**[[Blood cultures]]

	===Diagnosis===		===Diagnosis===

Rossdonaldson1: /* Evaluation */

2020-08-12T19:58:53Z

Evaluation

← Older revision		Revision as of 19:58, 12 August 2020
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	==Evaluation==		==Evaluation==
			[[File:PMC4800468 10.1177 2324709616638363-fig1.png\|thumb\|CT abdomen demonstrating enlarged spleen consistent with acute splenic sequestration crisis.]]
			===Workup===
	*Labs		*Labs
	**CBC		**CBC
Line 31:		Line 33:
	**LFTs		**LFTs
	**Blood cultures		**Blood cultures

			===Diagnosis===
	*Imaging not necessary to make diagnosis		*Imaging not necessary to make diagnosis

Rossdonaldson1: /* Disposition */

2020-08-05T18:21:03Z

Disposition

← Older revision		Revision as of 18:21, 5 August 2020
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	*Admission		*Admission

	===Complications===		==Complications==
	*[[Shock]]		*[[Shock]]
	*[[Splenic infarct]]		*[[Splenic infarct]]

Rossdonaldson1 at 18:20, 5 August 2020

2020-08-05T18:20:47Z

← Older revision		Revision as of 18:20, 5 August 2020
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	*Circulatory collapse		*Circulatory collapse
	*Splenomegaly		*Splenomegaly

	~~===Complications===~~
	*[[Shock]]
	*[[Splenic infarct]]
	*[[Splenic rupture]]
	*[[Sepsis]]

	==Differential Diagnosis==		==Differential Diagnosis==

	{{Sickle cell DDX}}		{{Sickle cell DDX}}


	==Evaluation==		==Evaluation==
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	==Disposition==		==Disposition==
	*Admission		*Admission

			===Complications===
			*[[Shock]]
			*[[Splenic infarct]]
			*[[Splenic rupture]]
			*[[Sepsis]]

	==See Also==		==See Also==
	[[Sickle cell crisis]]		*[[Sickle cell crisis]]

	==External Links==		==External Links==
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	==References==		==References==
	<references/>		<references/>
	[[Category:GI]][[Category:Heme/Onc]]		[[Category:GI]]
			[[Category:Heme/Onc]]

Ostermayer at 06:22, 1 August 2020

2020-08-01T06:22:27Z

← Older revision		Revision as of 06:22, 1 August 2020
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	==Background==		==Background==
	*Leading cause of pediatric mortality related to [[sickle cell disease]]		*Leading cause of pediatric mortality related to [[sickle cell disease]]<ref>Brousse V et al. Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 pediatric patients. British Journal of Haematology. 2012;156:643-648.</ref>
	*More common in pediatric patients as many adults with SCD have autoinfarcted their spleen		*More common in pediatric patients as many adults with SCD have autoinfarcted their spleen
	*Earliest life threatening complication of SCD with median age 1-4<sup>3</sup>		*Earliest life threatening complication of SCD with median age 1-4<sup>3</sup>
	*Red blood cells sickle, aggregate, and occlude splenic vasculature		*Red blood cells sickle, aggregate, and occlude splenic vasculature<ref>Brousse V et al. The spleen and sickle cell disease: the sick(led) spleen. British Journal of Haematology. 2014;166:165-176.</ref><ref>Lovett PB et al. Sickle Cell Disease in the Emergency Department. Emerg Med Clin N Am. 2014;32(3):629-647.</ref>
	*Sequestering leads to splenomegaly		*Sequestering leads to splenomegaly
	**Defined as splenomegaly and a 2g/dL drop in hemoglobin		**Defined as splenomegaly and a 2g/dL drop in hemoglobin
Line 43:		Line 43:
	==Management==		==Management==
	*Pain control		*Pain control
	*IV fluid resuscitation and blood transfusion		*IV fluid resuscitation and blood transfusion<ref>Abboud MR. Standard management of sickle cell disease complications. Hematology/Oncology and Stem Cell Therapy. 2020;3(1):85-90.
			</ref>
	**Caution with IVF if anemia is severe		**Caution with IVF if anemia is severe
	**Goal Hct 35% to avoid [[hyperviscosity syndrome]]<sup>3</sup>		**Goal Hct 35% to avoid [[hyperviscosity syndrome]]<sup>3</sup>
	*Treat underlying cause if found - infection common		*Treat underlying cause if found - infection common
	*Possible splenectomy		*Possible splenectomy
	**Recurrence rate is 50-75%<sup>1,2,3</sup>		**Recurrence rate is 50-75%<sup>1,2,3</sup><ref>Kane I, Nagalli S. Splenic Sequestration Crisis. [Updated 2020 Jul 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553164/</ref>
	*Hematology consultation		*Hematology consultation

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	==References==		==References==
	<references/>		<references/>
	~~# Abboud MR. Standard management of sickle cell disease complications. Hematology/Oncology and Stem Cell Therapy. 2020;3(1)~~:~~85-90.~~		[[Category:GI]][[Category:Heme/Onc]]
	~~# Brousse V et al. Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 pediatric patients. British Journal of Haematology. 2012;156:643-648.~~
	~~# Brousse V et al. The spleen and sickle cell disease: the sick(led) spleen. British Journal of Haematology. 2014;166:165-176.~~
	~~# Kane I, Nagalli S. Splenic Sequestration Crisis.~~ [~~Updated 2020 Jul 6]. In: StatPearls~~ [~~Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https~~:/~~/www.ncbi.nlm.nih.gov/books/NBK553164/~~
	~~# Lovett PB et al. Sickle Cell Disease in the Emergency Department. Emerg Med Clin N Am. 2014;32(3):629-647.~~

Fredvarone: Created page with "==Background== Leading cause of pediatric mortality related to sickle cell disease More common in pediatric patients as many adults with SCD have autoinfarcted their spl..."

2020-07-30T16:11:57Z

Created page with "==Background== *Leading cause of pediatric mortality related to sickle cell disease *More common in pediatric patients as many adults with SCD have autoinfarcted their spl..."

New page

==Background==
*Leading cause of pediatric mortality related to [[sickle cell disease]]
*More common in pediatric patients as many adults with SCD have autoinfarcted their spleen
*Earliest life threatening complication of SCD with median age 1-43
*Red blood cells sickle, aggregate, and occlude splenic vasculature
*Sequestering leads to splenomegaly
**Defined as splenomegaly and a 2g/dL drop in hemoglobin
***Some resources differentiate between major and minor episodes depending on the hgb drop
*Lifelong prevalence 7-30%3
*Often precipitated by underlying infection ([[pneumonia]], [[gastroenteritis]])

==Clinical Features==
*[[Abdominal pain]]
*[[Fatigue]]
*Pallor
*[[Tachycardia]]
*[[Anemia]]
*[[Hypotension]]
*Circulatory collapse
*Splenomegaly

===Complications===
*[[Shock]]
*[[Splenic infarct]]
*[[Splenic rupture]]
*[[Sepsis]]

==Differential Diagnosis==

{{Sickle cell DDX}}

==Evaluation==
*Labs
**CBC
**BMP
**LDH
**Reticulocyte count
**LFTs
**Blood cultures
*Imaging not necessary to make diagnosis

==Management==
*Pain control
*IV fluid resuscitation and blood transfusion
**Caution with IVF if anemia is severe
**Goal Hct 35% to avoid [[hyperviscosity syndrome]]3
*Treat underlying cause if found - infection common
*Possible splenectomy
**Recurrence rate is 50-75%1,2,3
*Hematology consultation

==Disposition==
*Admission

==See Also==
[[Sickle cell crisis]]

==External Links==

==References==
<references/>
# Abboud MR. Standard management of sickle cell disease complications. Hematology/Oncology and Stem Cell Therapy. 2020;3(1):85-90.
# Brousse V et al. Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 pediatric patients. British Journal of Haematology. 2012;156:643-648.
# Brousse V et al. The spleen and sickle cell disease: the sick(led) spleen. British Journal of Haematology. 2014;166:165-176.
# Kane I, Nagalli S. Splenic Sequestration Crisis. [Updated 2020 Jul 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553164/
# Lovett PB et al. Sickle Cell Disease in the Emergency Department. Emerg Med Clin N Am. 2014;32(3):629-647.