Synthetic cannabinoids - Revision history

Mrosen5506: /* Clinical Features */

2018-08-12T18:49:41Z

Clinical Features

← Older revision		Revision as of 18:49, 12 August 2018
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	*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, delirium		*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, delirium
	*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>		*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>
			*Serious bleeding as some synthetic cannibinoids contaminated with long acting vitamin K-dependent antagonists (brodifacoum) <ref>Moritz, E., Austin, C., Wahl, M., DesLauriers, C., Navon, L., Walblay, K., … Layden, J. (2018). Notes from the Field: Outbreak of Severe Illness Linked to the Vitamin K Antagonist Brodifacoum and Use of Synthetic Cannabinoids - Illinois, March-April 2018. MMWR. Morbidity and Mortality Weekly Report, 67(21), 607–608.</ref>

	==Differential Diagnosis==		==Differential Diagnosis==

Kramarsh: /* Clinical Features */

2018-03-26T16:19:16Z

Clinical Features

← Older revision		Revision as of 16:19, 26 March 2018
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	*Typical onset of 10-30 min and taper over 1-2 hours		*Typical onset of 10-30 min and taper over 1-2 hours
	*'''Tachycardia and hypertension''' common (distinguishing it from MJ use)		*'''Tachycardia and hypertension''' common (distinguishing it from MJ use)
	*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, ~~deli~~		*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, delirium
	*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>		*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>

Kramarsh: /* Management */

2018-03-26T16:18:48Z

Management

← Older revision		Revision as of 16:18, 26 March 2018
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	==Management==		==Management==
	*Supportive care		*Supportive care
			*May require sedative agent such as benzodiazepines or antipsychotics, as well as physical restraints, if severely agitated and posing a threat to self and staff

	==Disposition==		==Disposition==

Mholtz at 18:18, 3 February 2017

2017-02-03T18:18:11Z

← Older revision		Revision as of 18:18, 3 February 2017
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	==Background==		==Background==
	*Common names: spice, K2, Moon Rocks, Blue Lotus, many others		*Common street names: spice, K2, Moon Rocks, Blue Lotus, many others
	*Active ingredients~~: cannabicyclohexano, JWH-018, JWH-073, HU-210, XLR-11, others~~		*Active ingredients frequently change to avoid legal proscription
	*~~Far more potent than THC (100-800x)~~		*Generally contains cannabinoid receptor agonists (CB1 or CB2) that are far more potent than THC
	*Cannabinoid receptor agonists (CB1 or CB2)		*Does not show up on routine tox screen
	*Do not show up ~~as marijuana~~ on routine tox ~~testing~~		*Generally smoked, but can be imbibed as a tea
	*Generally smoked, but can be ~~drank~~ as a tea

	==Clinical Features==		==Clinical Features==
	*Similar effect to marijuana at low doses, but may be more intense and cause an acute ~~'''agitated delerium'''~~		*Similar effect to marijuana at low doses, but may be more intense and cause an acute [[Excited delirium]]
	*Typical ~~effects~~ 10-30 min and taper over 1-2 hours		*Typical onset of 10-30 min and taper over 1-2 hours
	*'''Tachycardia and hypertension''' common (distinguishing it from MJ use)		*'''Tachycardia and hypertension''' common (distinguishing it from MJ use)
	*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli		*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli
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	{{Drugs of abuse types}}		{{Drugs of abuse types}}

			==Evaluation==
			*Clinical diagnosis

	==Management==		==Management==
	*Supportive		*Supportive care
	*[[Benzodiazepines ]]
	*~~[[Zofran]]~~		==Disposition==
			*Generally may be discharged once sober (assuming no adverse effects that would mandate admission)

	==See Also==		==See Also==

Neil.m.young: Text replacement - " " to ""

2017-01-30T13:17:54Z

Text replacement - "&nbsp" to ""

← Older revision		Revision as of 13:17, 30 January 2017
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	*Typical effects 10-30 min and taper over 1-2 hours		*Typical effects 10-30 min and taper over 1-2 hours
	*'''Tachycardia and hypertension''' common (distinguishing it from MJ use)		*'''Tachycardia and hypertension''' common (distinguishing it from MJ use)
	*Adverse effects:~~&nbsp~~;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli		*Adverse effects:;nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli
	*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>		*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref>

Neil.m.young: Text replacement - "==Treatment==" to "==Management=="

2016-07-10T00:49:06Z

Text replacement - "==Treatment==" to "==Management=="

← Older revision		Revision as of 00:49, 10 July 2016
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	{{Drugs of abuse types}}		{{Drugs of abuse types}}

	==~~Treatment~~==		==Management==
	*Supportive		*Supportive
	*[[Benzodiazepines ]]		*[[Benzodiazepines ]]

Rossdonaldson1: /* Source */

2016-05-12T23:07:15Z

Source

← Older revision		Revision as of 23:07, 12 May 2016
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	*[[Marijuana]]		*[[Marijuana]]

	==~~Source~~==		==References==
	~~David Burbulys, MD lecture 9/2012~~
	<references/>		<references/>

	[[Category:Toxicology]]		[[Category:Toxicology]]

Rossdonaldson1: /* Differential Diagnosis */

2016-05-12T23:06:58Z

Differential Diagnosis

← Older revision		Revision as of 23:06, 12 May 2016
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	==Differential Diagnosis==		==Differential Diagnosis==
	{{Sympathomimetic types}}		{{Sympathomimetic types}}

			{{Drugs of abuse types}}

	==Treatment==		==Treatment==

Rossdonaldson1: /* See Also */

2016-05-12T23:06:37Z

Ostermayer: Text replacement - "Category:Tox" to "Category:Toxicology"

2016-03-22T16:23:36Z

Text replacement - "Category:Tox" to "Category:Toxicology"

← Older revision		Revision as of 16:23, 22 March 2016
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	<references/>		<references/>

	[[Category:~~Tox~~]]		[[Category:Toxicology]]

← Older revision		Revision as of 23:06, 12 May 2016
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	==See Also==		==See Also==
	*[[Sympathomimetic toxicity]]		*[[Sympathomimetic toxicity]]
			*[[Marijuana]]

	==Source==		==Source==