Template:Pediatric NAC dosing - Revision history

Ostermayer: /* IV */

2015-12-20T16:29:35Z

← Older revision		Revision as of 16:29, 20 December 2015
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	===IV===		===IV===
	''for pediatrics (0-18) the addition of a dilution of NAC should be followed to avoid electrolyte and fluid problems''		''for pediatrics (0-18) the addition of a dilution of NAC should be followed to avoid electrolyte and fluid problems''

	'''5 to 20 kg:'''		'''5 to 20 kg:'''
	*Loading Dose: 150 mg/kg '''in 3 mL/kg diluent''', infused over 1 hour		*Loading Dose: 150 mg/kg '''in 3 mL/kg diluent''', infused over 1 hour

Ostermayer at 16:27, 20 December 2015

2015-12-20T16:27:09Z

← Older revision		Revision as of 16:27, 20 December 2015
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			''For children there is a diluent added to the [[NAC]] so that there is no electrolyte and volume complications.''
	===PO===		===PO===
	*140 mg/kg body weight, orally, once as a loading dose		*140 mg/kg body weight, orally, once as a loading dose
	*Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total doses, unless repeated acetaminophen assays reveal nontoxic levels		*Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total doses, unless repeated acetaminophen assays reveal nontoxic levels
	~~Dose preparation is weight based:~~

	'''100 to 109 kg:'''		'''100 to 109 kg:'''

Ostermayer: /* PO */

2015-12-20T16:25:23Z

← Older revision		Revision as of 16:25, 20 December 2015
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	'''100 to 109 kg:'''		'''100 to 109 kg:'''
	*Loading dose: 15 g (75 mL) in 225 mL diluent; total volume: 300 mL		*Loading dose: 15 g (75 mL) '''in 225 mL diluent;''' total volume: 300 mL
	*Maintenance Dose: 7.5 g (37 mL) in 113 mL diluent; total volume: 150 mL		*Maintenance Dose: 7.5 g (37 mL) '''in 113 mL diluent;''' total volume: 150 mL

	'''90 to 99 kg:'''		'''90 to 99 kg:'''
	*Loading dose: 14 g (70 mL) in 210 mL diluent; total volume: 280 mL		*Loading dose: 14 g (70 mL) '''in 210 mL diluent;''' total volume: 280 mL
	*Maintenance Dose: 7 g (35 mL) in 105 mL diluent; total volume: 140 mL		*Maintenance Dose: 7 g (35 mL) '''in 105 mL diluent;''' total volume: 140 mL

	'''80 to 89 kg'''		'''80 to 89 kg'''
	*Loading dose: 13 g (65 mL) in 195 ~~mL) in 210~~ mL diluent; total volume: 260 mL		*Loading dose: 13 g (65 mL) '''in 195 mL diluent'''; total volume: 260 mL
	*Maintenance Dose: 6.5 g (33 mL) in 97 mL diluent; total volume: 130 mL		*Maintenance Dose: 6.5 g (33 mL) '''in 97 mL diluent'''; total volume: 130 mL

	'''70 to 79 kg'''		'''70 to 79 kg'''
	*Loading dose: 11 g (55 mL) in 165 mL) in ~~210 mL~~ diluent; total volume: 220 mL		*Loading dose: 11 g (55 mL) in '''165 mL in diluent'''; total volume: 220 mL
	*Maintenance Dose: 5.5 g (28 mL) in 82 mL diluent; total volume: 110 mL		*Maintenance Dose: 5.5 g (28 mL) in '''82 mL diluent'''; total volume: 110 mL

	'''60 to 69 kg'''		'''60 to 69 kg'''
	*Loading dose: 10 g (50 mL) in 150 ~~mL) in 210~~ mL diluent; total volume: 200 mL		*Loading dose: 10 g (50 mL) '''in 150 mL diluent'''; total volume: 200 mL
	*Maintenance Dose: 5 g (25 mL) in 75 mL diluent; total volume: 100 mL		*Maintenance Dose: 5 g (25 mL) '''in 75 mL diluent'''; total volume: 100 mL

	'''50 to 59 kg'''		'''50 to 59 kg'''
	*Loading dose: 8 g (40 mL) in 120 ~~mL) in 210~~ mL diluent; total volume: 160 mL		*Loading dose: 8 g (40 mL) in '''120 mL diluent'''; total volume: 160 mL
	*Maintenance Dose: 4 g (20 mL) in 60 mL diluent; total volume: 80 mL		*Maintenance Dose: 4 g (20 mL) '''in 60 mL diluent'''; total volume: 80 mL

	'''40 to 49 kg'''		'''40 to 49 kg'''
	*Loading dose: 7 g (35 mL) in 105 ~~mL) in 210~~ mL diluent; total volume: 140 mL		*Loading dose: 7 g (35 mL) '''in 105 mL diluent'''; total volume: 140 mL
	*Maintenance Dose: 3.5 g (18 mL) in 52 mL diluent; total volume: 70 mL		*Maintenance Dose: 3.5 g (18 mL)''' in 52 mL diluent'''; total volume: 70 mL

	'''30 to 39 kg'''		'''30 to 39 kg'''
	*Loading dose: 6 g (30 mL) in 90 ~~mL) in 210~~ mL diluent; total volume: 120 mL		*Loading dose: 6 g (30 mL) '''in 90 mL diluent'''; total volume: 120 mL
	*Maintenance Dose: 3 g (15 mL) in 45 mL diluent; total volume: 60 mL		*Maintenance Dose: 3 g (15 mL) '''in 45 mL diluent'''; total volume: 60 mL

	'''20 to 29 kg'''		'''20 to 29 kg'''
	*Loading dose: 4 g (20 mL) in 60 ~~mL) in 210~~ mL diluent; total volume: 80 mL		*Loading dose: 4 g (20 mL)''' in 60 mL diluent'''; total volume: 80 mL
	*Maintenance Dose: 2 g (10 mL) in 30 mL diluent; total volume: 40 mL		*Maintenance Dose: 2 g (10 mL) '''in 30 mL diluent'''; total volume: 40 mL

	'''Less than 20 kg'''		'''Less than 20 kg'''

Ostermayer: Created page with "===PO=== 140 mg/kg body weight, orally, once as a loading dose Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total..."

2015-12-20T16:17:08Z

Created page with "===PO=== *140 mg/kg body weight, orally, once as a loading dose *Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total..."

New page

===PO===
*140 mg/kg body weight, orally, once as a loading dose
*Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total doses, unless repeated acetaminophen assays reveal nontoxic levels
Dose preparation is weight based:

'''100 to 109 kg:'''
*Loading dose: 15 g (75 mL) in 225 mL diluent; total volume: 300 mL
*Maintenance Dose: 7.5 g (37 mL) in 113 mL diluent; total volume: 150 mL

'''90 to 99 kg:'''
*Loading dose: 14 g (70 mL) in 210 mL diluent; total volume: 280 mL
*Maintenance Dose: 7 g (35 mL) in 105 mL diluent; total volume: 140 mL

'''80 to 89 kg'''
*Loading dose: 13 g (65 mL) in 195 mL) in 210 mL diluent; total volume: 260 mL
*Maintenance Dose: 6.5 g (33 mL) in 97 mL diluent; total volume: 130 mL

'''70 to 79 kg'''
*Loading dose: 11 g (55 mL) in 165 mL) in 210 mL diluent; total volume: 220 mL
*Maintenance Dose: 5.5 g (28 mL) in 82 mL diluent; total volume: 110 mL

'''60 to 69 kg'''
*Loading dose: 10 g (50 mL) in 150 mL) in 210 mL diluent; total volume: 200 mL
*Maintenance Dose: 5 g (25 mL) in 75 mL diluent; total volume: 100 mL

'''50 to 59 kg'''
*Loading dose: 8 g (40 mL) in 120 mL) in 210 mL diluent; total volume: 160 mL
*Maintenance Dose: 4 g (20 mL) in 60 mL diluent; total volume: 80 mL

'''40 to 49 kg'''
*Loading dose: 7 g (35 mL) in 105 mL) in 210 mL diluent; total volume: 140 mL
*Maintenance Dose: 3.5 g (18 mL) in 52 mL diluent; total volume: 70 mL

'''30 to 39 kg'''
*Loading dose: 6 g (30 mL) in 90 mL) in 210 mL diluent; total volume: 120 mL
*Maintenance Dose: 3 g (15 mL) in 45 mL diluent; total volume: 60 mL

'''20 to 29 kg'''
*Loading dose: 4 g (20 mL) in 60 mL) in 210 mL diluent; total volume: 80 mL
*Maintenance Dose: 2 g (10 mL) in 30 mL diluent; total volume: 40 mL

'''Less than 20 kg'''
*Add 3 mL of diluent to each 1 mL (200 mg) of 20% acetylcysteine solution
*Loading dose: 140 g/kg
*Maintenance Dose: 70 g/kg

===IV===
''for pediatrics (0-18) the addition of a dilution of NAC should be followed to avoid electrolyte and fluid problems''
'''5 to 20 kg:'''
*Loading Dose: 150 mg/kg '''in 3 mL/kg diluent''', infused over 1 hour
*Second Dose: 50 mg/kg '''in 7 mL/kg diluent''', infused over 4 hours
*Third Dose: 100 mg/kg '''in 14 mL/kg diluent''', infused over 16 hours

'''21 to 40 kg:'''
*Loading Dose: 150 mg/kg '''in 100 mL diluent''', infused over 1 hour
*Second Dose: 50 mg/kg '''in 250 mL diluent''', infused over 4 hours
*Third Dose: 100 mg/kg '''in 500 mL diluent''', infused over 16 hours

'''Over 100 kg:'''
*Loading Dose: 15,000 mg '''in 200 mL diluent''', infused over 1 hour
*Second Dose: 5,000 mg '''in 500 mL diluent''', infused over 4 hours
*Third Dose: 10,000 mg '''in 1,000 mL diluent''', infused over 16 hours

Template:Pediatric NAC dosing - Revision history

Ostermayer: /* IV */

Ostermayer at 16:27, 20 December 2015

Ostermayer: /* PO */

Ostermayer: Created page with "===PO=== *140 mg/kg body weight, orally, once as a loading dose *Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total..."

Ostermayer: Created page with "===PO=== 140 mg/kg body weight, orally, once as a loading dose Maintenance Dose: 70 mg/kg body weight, orally, 4 hours after the loading dose and every 4 hours for 17 total..."