Template:Toxic Alcohols Anion/Osmolar Gaps - Revision history

Ostermayer at 19:42, 12 March 2026

2026-03-12T19:42:57Z

← Older revision		Revision as of 19:42, 12 March 2026
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	===[[Toxic Alcohols]] Anion/Osmolar Gaps===		===[[Toxic Alcohols]] Anion/Osmolar Gaps===
	{\| class="wikitable"		{\| class="wikitable"
	! [[Osmolar gap]] !! [[Metabolic acidosis]] ~~!! Osmolar gap~~ !! [[Anion gap]] !! Ketones !! Ca ~~Oxolate stones~~ !! Reduced vision !! Management		! Substance !! [[Osmolar gap]] !! [[Metabolic acidosis]] !! [[Anion gap]] !! Ketones !! Ca Oxalate crystals !! Reduced vision !! Management
	\|-		\|-
	\| [[Ethanol ]]\|\| + \|\| + \|\| + (if ketoacidosis) \|\| + \|\| - \|\| \|\| Mainly supportive		\| [[Ethanol]] \|\| + \|\| +/- (if ketoacidosis) \|\| +/- (if ketoacidosis) \|\| +/- \|\| - \|\| - \|\| Mainly supportive
	\|-		\|-
	\| [[Ethylene glycol]] \|\| + \|\| + \|\| + \|\| - \|\| + \|\| - \|\| [[Fomepizole]], [[Thiamine]], [[Pyridoxine]], +/- ~~Dialysis~~		\| [[Ethylene glycol]] \|\| + (early)* \|\| + \|\| + \|\| - \|\| + \|\| - \|\| [[Fomepizole]], [[Thiamine]], [[Pyridoxine]], +/- Dialysis
	\|-		\|-
	\| [[Methanol]] \|\| + \|\| + ~~(early on, then disappears)~~ \|\| + \|\| - \|\| - \|\| + \|\| [[Fomepizole]] or ethanol, Folinic acid, +/- ~~Dialysis~~		\| [[Methanol]] \|\| + (early)* \|\| + \|\| + \|\| - \|\| - \|\| + \|\| [[Fomepizole]] or ethanol, [[Folic Acid\|Folinic acid/Folic acid]], +/- Dialysis
	\|-		\|-
	\| [[Isopropyl alcohol]] \|\| - \|\| + \|\| - \|\| + \|\| - \|\| + \|\| Mainly supportive		\| [[Isopropyl alcohol]] \|\| + \|\| - \|\| - \|\| + (acetonemia without acidosis) \|\| - \|\| - \|\| Mainly supportive, +/- Dialysis if severe
	\|-		\|-
	\| Propylene ~~gylcol~~ \|\| + \|\| + ~~(initially)~~ \|\| + (~~converted to lactate~~) \|\| - \|\| - \|\| - \|\|		\| [[Propylene glycol]] \|\| + \|\| + \|\| + (lactic acidosis) \|\| - \|\| - \|\| - \|\| D/C offending agent (e.g. IV lorazepam/diazepam), supportive, +/- Dialysis
	\|}		\|}
			;*'''Osmolar gap → Anion gap transition:''' For all toxic alcohols, the osmolar gap is elevated '''early''' (parent compound present) and '''decreases over time''' as the alcohol is metabolized into organic acid metabolites, which then produce an anion gap metabolic acidosis. A '''normal osmolar gap does NOT exclude''' toxic alcohol ingestion if presentation is delayed.
			;Key distinguishing features:
			;*'''Isopropyl alcohol:''' The '''only''' toxic alcohol that causes ketosis '''without''' metabolic acidosis (metabolized to acetone, not an organic acid)
			;*'''Ethylene glycol:''' Ca oxalate crystals in urine + anion gap metabolic acidosis + renal failure
			;*'''Methanol:''' Visual disturbances (blurred vision, "snowfield" vision, blindness) + anion gap metabolic acidosis + optic disc hyperemia on fundoscopy

Rossdonaldson1: /* Toxic Alcohols Anion/Osmolar Gaps */

2024-05-08T20:31:15Z

Toxic Alcohols Anion/Osmolar Gaps

← Older revision		Revision as of 20:31, 8 May 2024
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	===[[Toxic Alcohols]] Anion/Osmolar Gaps===		===[[Toxic Alcohols]] Anion/Osmolar Gaps===
	{\| class="wikitable"		{\| class="wikitable"
	!		! [[Osmolar gap]] !! [[Metabolic acidosis]] !! Osmolar gap !! [[Anion gap]] !! Ketones !! Ca Oxolate stones !! Reduced vision !! Management
	! [[Osmolar gap]]
	! [[Anion gap]]
	! Management
	\|-		\|-
	\| [[Ethanol]]		\| [[Ethanol ]]\|\| + \|\| + \|\| + (if ketoacidosis) \|\| + \|\| - \|\| \|\| Mainly supportive
	\| +
	\| + if ketoacidosis
	\| Mainly supportive
	\|-		\|-
	\| [[Ethylene glycol]]		\| [[Ethylene glycol]] \|\| + \|\| + \|\| + \|\| - \|\| + \|\| - \|\| [[Fomepizole]], [[Thiamine]], [[Pyridoxine]], +/- Dialysis
	\| +
	\| +
	\| [[Fomepizole]], [[Thiamine]], [[Pyridoxine]], +/- ~~[[Dialysis]]~~
	\|-		\|-
	\| [[Methanol]]		\| [[Methanol]] \|\| + \|\| + (early on, then disappears) \|\| + \|\| - \|\| - \|\| + \|\| [[Fomepizole]] or ethanol, Folinic acid, +/- Dialysis
	\| +
	\| +
	\| [[Fomepizole]] or ethanol, Folinic acid, +/- ~~[[Dialysis]]~~
	\|-		\|-
	\| [[Isopropyl alcohol]]		\| [[Isopropyl alcohol]] \|\| - \|\| + \|\| - \|\| + \|\| - \|\| + \|\| Mainly supportive
	\| +		\|-
	\| -		\| Propylene gylcol \|\| + \|\| + (initially) \|\| + (converted to lactate) \|\| - \|\| - \|\| - \|\|
	\| ~~Mainly supportive~~
	\|}		\|}

Bchap23: /* Toxic Alcohols Anion/Osmolar Gaps */

2023-08-12T17:50:47Z

Toxic Alcohols Anion/Osmolar Gaps

← Older revision		Revision as of 17:50, 12 August 2023
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	\| +		\| +
	\| +		\| +
	\| [[Fomepizole]], Folinic acid, +/- [[Dialysis]]		\| [[Fomepizole]] or ethanol, Folinic acid, +/- [[Dialysis]]
	\|-		\|-
	\| [[Isopropyl alcohol]]		\| [[Isopropyl alcohol]]

Elcatracho: /* Toxic Alcohols Anion/Osmolar Gaps */

2021-02-10T20:48:14Z

Toxic Alcohols Anion/Osmolar Gaps

← Older revision		Revision as of 20:48, 10 February 2021
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	! [[Osmolar gap]]		! [[Osmolar gap]]
	! [[Anion gap]]		! [[Anion gap]]
			! Management
	\|-		\|-
	\| [[Ethanol]]		\| [[Ethanol]]
	\| +		\| +
	\| + if ketoacidosis		\| + if ketoacidosis
			\| Mainly supportive
	\|-		\|-
	\| [[Ethylene glycol]]		\| [[Ethylene glycol]]
	\| +		\| +
	\| +		\| +
			\| [[Fomepizole]], [[Thiamine]], [[Pyridoxine]], +/- [[Dialysis]]
	\|-		\|-
	\| [[Methanol]]		\| [[Methanol]]
	\| +		\| +
	\| +		\| +
			\| [[Fomepizole]], Folinic acid, +/- [[Dialysis]]
	\|-		\|-
	\| [[Isopropyl alcohol]]		\| [[Isopropyl alcohol]]
	\| +		\| +
	\| -		\| -
			\| Mainly supportive
	\|}		\|}

Rossdonaldson1: Created page with "===Toxic Alcohols Anion/Osmolar Gaps=== {| class="wikitable" ! ! Osmolar gap ! Anion gap |- | Ethanol | + | + if ketoacidosis |- | Ethylene glycol | + | +..."

2016-06-21T01:19:32Z

Created page with "===Toxic Alcohols Anion/Osmolar Gaps=== {| class="wikitable" ! ! Osmolar gap ! Anion gap |- | Ethanol | + | + if ketoacidosis |- | Ethylene glycol | + | +..."

New page

===[[Toxic Alcohols]] Anion/Osmolar Gaps===
{| class="wikitable"
!
! [[Osmolar gap]]
! [[Anion gap]]
|-
| [[Ethanol]]
| +
| + if ketoacidosis
|-
| [[Ethylene glycol]]
| +
| +
|-
| [[Methanol]]
| +
| +
|-
| [[Isopropyl alcohol]]
| +
| -
|}