https://wikem.org/w/index.php?action=history&feed=atom&title=Tizanidine 2026-04-18T13:18:36Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Tizanidine&diff=193887&oldid=prev 2018-09-17T05:47:29Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Muscle relaxant<br /> *Dosage Forms: Cap: 2mg, 4mg; Tab: 2mg, 4mg<br /> *Routes of Administration: Oral<br /> *Common Trade Names: Zanaflex<br /> <br /> ==Adult Dosing==<br /> ===Spasticity===<br /> *Individualize dose PO q6-8h prn<br /> **Start 2mg PO x1<br /> **Max: 3 doses/24h up to 36mg/day<br /> **Taper dose 2-4 mg/day to D/C if prolonged use<br /> <br /> ==Pediatric Dosing==<br /> Safety/efficacy not established in pediatric patients<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *Consider alternative during pregnancy<br /> *Possible risk of fetal harm<br /> <br /> ===Lactation risk===<br /> *Consider alternative while breastfeeding<br /> *Possible risk of infant sedation and hypotension<br /> <br /> ===Renal Dosing===<br /> *Adult: CrCl &lt;25: Decrease dose<br /> <br /> ===Hepatic Dosing===<br /> *Adult: Not defined<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Avoid abrupt withdrawal<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *[[Hepatotoxicity]]<br /> *[[Bradycardia]], [[hypotension]]<br /> *[[Syncope]]<br /> *[[Hallucinations]]<br /> *[[Anaphylaxis]], [[Stevens-Johnson syndrome]], exfoliative dermatitis<br /> *Abrupt D/C: Rebound HTN, tachycardia, hypertonia<br /> <br /> ===Common===<br /> *[[Xerostomia]]<br /> *Somnolence, [[dizziness]], nervousness<br /> *[[UTI]], urinary frequency<br /> *[[Constipation]], [[Vomiting]]<br /> *[[Dyskinesia]]<br /> <br /> ==Pharmacology==<br /> *Half-life: 2.5 hr<br /> *Metabolism: Liver; CYP450: 1A2 substrate<br /> *Excretion: Urine 60%, feces 20%<br /> <br /> ==Mechanism of Action==<br /> *Binds to central alpha-2 adrenergic receptors, increasing presynaptic motor neuron inhibition and reducing spasticity<br /> *Centrally acting<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

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