Transfusion-associated graft-versus-host disease - Revision history

ClaireLewis: /* See Also */

2019-10-01T18:57:04Z

ClaireLewis: /* See Also */

2019-10-01T18:56:51Z

ClaireLewis at 18:56, 1 October 2019

2019-10-01T18:56:16Z

← Older revision		Revision as of 18:56, 1 October 2019
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	*Donor lymphocytes mount response against recipient tissue		*Donor lymphocytes mount response against recipient tissue
	*Risk factors (see also [[Blood products]]):		*Risk factors (see also [[Blood products]]):
	**Cellular components (whole blood, pRBCs)		**Cellular components (whole blood, [[pRBCs]])
	***Less incidence in platelet products		***Less incidence in [[platelets\|platelet products]]
	***Almost none in FFP		***Almost none in [[FFP]]
	**Recipient immunodeficiency		**Recipient immunodeficiency
	**Non-leukocyte irradiated blood products		**Non-leukocyte irradiated blood products
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	==Clinical Features==		==Clinical Features==
	*Signs and symptoms include<ref name="a"></ref>:		*Signs and symptoms include<ref name="a"></ref>:
	**Rash ~80%		**[[Rash]] ~70-80%
	**Rash ~70%
	**[[Diarrhea]] ~40%		**[[Diarrhea]] ~40%
	**Hepatomegaly ~15%		**[[Hepatomegaly]] ~15%
	**Liver injury ~70%		**[[liver failure\|Liver injury]] ~70%
	**Pancytopenia ~65%		**[[Pancytopenia]] ~65%
	*Transfusion usually within 1-2 weeks prior to symptom onset		*Transfusion usually within 1-2 weeks prior to symptom onset
	*By definition, can be between 2 days - 6 weeks from transfusion		*By definition, can be between 2 days - 6 weeks from transfusion
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	**Use leukocyte reduced, irradiated blood products		**Use leukocyte reduced, irradiated blood products
	*Supportive		*Supportive
	*Immunosuppressants, corticosteroids, cytotoxic agents have questionable efficacy		*Immunosuppressants, [[corticosteroids]], cytotoxic agents have questionable efficacy
	*Stem cell transplantation rescue		*Stem cell transplantation rescue

Rossdonaldson1: Text replacement - " wks " to " weeks "

2019-03-30T13:57:04Z

Text replacement - " wks " to " weeks "

← Older revision		Revision as of 13:57, 30 March 2019
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	==Background==		==Background==
	*> 24 hr, delayed complication of transfusion		*> 24 hr, delayed complication of transfusion
	*Mortality > 90%, usually within 1-3 ~~wks~~ of onset		*Mortality > 90%, usually within 1-3 weeks of onset
	*Donor lymphocytes mount response against recipient tissue		*Donor lymphocytes mount response against recipient tissue
	*Risk factors (see also [[Blood products]]):		*Risk factors (see also [[Blood products]]):
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	**Liver injury ~70%		**Liver injury ~70%
	**Pancytopenia ~65%		**Pancytopenia ~65%
	*Transfusion usually within 1-2 ~~wks~~ prior to symptom onset		*Transfusion usually within 1-2 weeks prior to symptom onset
	*By definition, can be between 2 days - 6 ~~wks~~ from transfusion		*By definition, can be between 2 days - 6 weeks from transfusion

	==Differential==		==Differential==

Rossdonaldson1: Text replacement - "Diarrhea" to "Diarrhea"

2016-09-24T18:20:15Z

Text replacement - "*Diarrhea" to "*Diarrhea"

← Older revision		Revision as of 18:20, 24 September 2016
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	**Rash ~80%		**Rash ~80%
	**Rash ~70%		**Rash ~70%
	**Diarrhea ~40%		**[[Diarrhea]] ~40%
	**Hepatomegaly ~15%		**Hepatomegaly ~15%
	**Liver injury ~70%		**Liver injury ~70%

Kxl328 at 01:45, 20 August 2016

2016-08-20T01:45:30Z

← Older revision		Revision as of 01:45, 20 August 2016
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	*Mortality > 90%, usually within 1-3 wks of onset		*Mortality > 90%, usually within 1-3 wks of onset
	*Donor lymphocytes mount response against recipient tissue		*Donor lymphocytes mount response against recipient tissue
	*Risk factors:		*Risk factors (see also [[Blood products]]):
	**Cellular components (whole blood, pRBCs)		**Cellular components (whole blood, pRBCs)
	***Less incidence in platelet products		***Less incidence in platelet products
	***Almost ~~non~~ in FFP		***Almost none in FFP
	**Recipient immunodeficiency		**Recipient immunodeficiency
	**Non-leukocyte irradiated blood products		**Non-leukocyte irradiated blood products

Neil.m.young at 21:19, 25 July 2016

2016-07-25T21:19:24Z

← Older revision		Revision as of 21:19, 25 July 2016
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	==References==		==References==
	*Roback JD (ed). Non-infectious complications of blood transfusion. Chapter 27, AABB Technical Manual, 17th edition. AABB, Bethesda, 2011.
	*Callum JL et al. Chapter 5, Transfusion Reactions. Bloody Easy 3: Blood Transfusions, Blood Alternatives and Transfusion Reactions: A Guide to Transfusion Medicine, 3rd edition. Canada: Ontario Regional Blood Coordinating Network, 2011. Available from: http://transfusionontario.org/en/cmdownloads/categories/bloody_easy/
	<references/>		<references/>

	[[Category:Heme/Onc]]		[[Category:Heme/Onc]]

Neil.m.young at 21:19, 25 July 2016

2016-07-25T21:19:02Z

← Older revision		Revision as of 21:19, 25 July 2016
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	==See Also==		==See Also==
			*[[Acute transfusion reaction]]

	==External Links==		==External Links==

Neil.m.young at 21:18, 25 July 2016

2016-07-25T21:18:10Z

← Older revision		Revision as of 21:18, 25 July 2016
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	==Differential==		==Differential==
	{{Transfusion reaction types}}		{{Transfusion reaction types}}

			==Evaluation==
			===Diagnosis===
			*Skin biopsy will suggest this pathology
			*Definitive diagnosis if patient's lymphocytes are found to have a different HLA phenotype from host tissue cells

	==Management==		==Management==
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	*Immunosuppressants, corticosteroids, cytotoxic agents have questionable efficacy		*Immunosuppressants, corticosteroids, cytotoxic agents have questionable efficacy
	*Stem cell transplantation rescue		*Stem cell transplantation rescue

			==See Also==

			==External Links==
			*[http://transfusionontario.org/en/cmdownloads/categories/bloody_easy/ Bloody Easy 3: Blood Transfusions, Blood Alternatives and Transfusion Reactions - A Guide to Transfusion Medicine]

	==References==		==References==

Neil.m.young at 21:09, 25 July 2016

2016-07-25T21:09:36Z

← Older revision		Revision as of 21:09, 25 July 2016
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	**Blood products stored less than 11 days		**Blood products stored less than 11 days
	***Longer shelf time associated with less incidence		***Longer shelf time associated with less incidence
	***In review of ~350 cases, only 10 identified between 11-14 days<ref>Kopolovic I et al. A systematic review of transfusion-associated graft-versus-host disease. Blood. 2015 Jul 16;126(3):406-14.</ref>		***In review of ~350 cases, only 10 identified between 11-14 days<ref name="a">Kopolovic I et al. A systematic review of transfusion-associated graft-versus-host disease. Blood. 2015 Jul 16;126(3):406-14.</ref>

	==Clinical Features==		==Clinical Features==
	*Signs and symptoms include<ref>~~Kopolovic I et al. A systematic review of transfusion-associated graft-versus-host disease. Blood. 2015 Jul 16;126(3):406-14.~~</ref>:		*Signs and symptoms include<ref name="a"></ref>:
	**Rash ~80%		**Rash ~80%
	**Rash ~70%		**Rash ~70%

← Older revision		Revision as of 18:57, 1 October 2019
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	==See Also==		==See Also==
	*[[Acute transfusion reaction]]		*[[Acute transfusion reaction]]
	*[[~~Graft-versus-host-disease~~]]		*[[GVHD]]

	==External Links==		==External Links==

Transfusion-associated graft-versus-host disease - Revision history

ClaireLewis: /* See Also */

ClaireLewis: /* See Also */

ClaireLewis at 18:56, 1 October 2019

Rossdonaldson1: Text replacement - " wks " to " weeks "

Rossdonaldson1: Text replacement - "*Diarrhea" to "*Diarrhea"

Kxl328 at 01:45, 20 August 2016

Neil.m.young at 21:19, 25 July 2016

Neil.m.young at 21:19, 25 July 2016

Neil.m.young at 21:18, 25 July 2016

Neil.m.young at 21:09, 25 July 2016

Rossdonaldson1: Text replacement - "Diarrhea" to "Diarrhea"