Transplant complications - Revision history

ClaireLewis: /* InfectionsLong B, Koyfman A. The emergency medicine approach to transplant complications. Am J Emerg Med. 2016;34(11):2200-2208. */

2019-08-23T02:36:31Z

InfectionsLong B, Koyfman A. The emergency medicine approach to transplant complications. Am J Emerg Med. 2016;34(11):2200-2208.

← Older revision		Revision as of 02:36, 23 August 2019
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	*Early (within the first month)		*Early (within the first month)
	**Donor-derived - bacterial, fungal, parasitic		**Donor-derived - bacterial, fungal, parasitic
	**Nosocomial & surgical-site - C diff, aspiration ~~pneumonia~~, UTI, surgical-site, superinfection of graft tissue		**Nosocomial & surgical-site - [[C. diff]], [[aspiration Pneumonia]], [[UTI]], surgical-site, superinfection of graft tissue
	*Intermediate (1-6 months after)		*Intermediate (1-6 months after)
	**'''Highest risk for opportunistic infections''' - PCP, TB, fungal (~~Cryptococcus~~, ~~Histoplasma~~), viral (BK virus, ~~Hepatitis~~ B/C, CMV)		**'''Highest risk for opportunistic infections''' - [[PCP]], [[TB]], fungal ([[cryptococcus]], [[histoplasma]]), viral (BK virus, [[hepatitis B]]/[[hepatitis C\|C]], [[CMV]])
	**Dormant host infection reactivation - HSV, VZV, EBV		**Dormant host infection reactivation - [[HSV]], [[VZV]], [[EBV]]
	*Late (more than 6 months after)		*Late (more than 6 months after)
	**Community-acquired infection		**Community-acquired infection

2019-06-09T20:51:34Z

← Older revision		Revision as of 20:51, 9 June 2019
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	{{Immunosuppressant medication complications}}		{{Immunosuppressant medication complications}}

			===Infections<ref>Long B, Koyfman A. The emergency medicine approach to transplant complications. Am J Emerg Med. 2016;34(11):2200-2208.</ref>===
			Time from transplantation affects the risk and type of infection.
			*Early (within the first month)
			**Donor-derived - bacterial, fungal, parasitic
			**Nosocomial & surgical-site - C diff, aspiration pneumonia, UTI, surgical-site, superinfection of graft tissue
			*Intermediate (1-6 months after)
			**'''Highest risk for opportunistic infections''' - PCP, TB, fungal (Cryptococcus, Histoplasma), viral (BK virus, Hepatitis B/C, CMV)
			**Dormant host infection reactivation - HSV, VZV, EBV
			*Late (more than 6 months after)
			**Community-acquired infection

	==Types==		==Types==

2016-09-29T02:43:27Z

Types

← Older revision		Revision as of 02:43, 29 September 2016
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	==Types==		==Types==
	*[[Graft-vs-host disease]]		*[[Graft-vs-host disease]]
			*[[Stem cell transplant complications]]
	*[[Kidney transplant complications]]		*[[Kidney transplant complications]]
	*[[Liver transplant complications]]		*[[Liver transplant complications]]
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	*[[Pancreas transplant complications]]		*[[Pancreas transplant complications]]
	*More severe or opportunistic infections due to immunocompromise		*More severe or opportunistic infections due to immunocompromise
	**May be afebrile due to ~~immunosupression~~, have low treshhold for infectious work-up		**May be afebrile due to immunosuppression, have low treshhold for infectious work-up

	==See Also==		==See Also==

2016-09-23T12:31:00Z

← Older revision		Revision as of 12:31, 23 September 2016
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	==Background==		==Background==
	*Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)		*Transplanted (solid) organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)
	*Most transplant-related emergencies due to one of the following:		*Most transplant-related emergencies due to one of the following:
	**Infection		**Infection

2016-09-05T21:10:50Z

Background

← Older revision		Revision as of 21:10, 5 September 2016
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	**Medication side effect		**Medication side effect
	**[[Graft-versus-host disease]]		**[[Graft-versus-host disease]]
	**Postoperative complications ~~(i.e.~~		**Postoperative complications
	**Altered physiology due to transplanted organ		**Altered physiology due to transplanted organ

2016-09-05T20:16:55Z

← Older revision		Revision as of 20:16, 5 September 2016
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	==Background==		==Background==
	*Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)		*Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)
	*Most transplant ~~patients require lifelong immunosuppression~~		*Most transplant-related emergencies due to one of the following:
			**Infection
			**Medication side effect
			**[[Graft-versus-host disease]]
			**Postoperative complications (i.e.
			**Altered physiology due to transplanted organ

	===Epidemiology===		===Epidemiology===
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	*[[Pancreas transplant complications]]		*[[Pancreas transplant complications]]
	*More severe or opportunistic infections due to immunocompromise		*More severe or opportunistic infections due to immunocompromise
			**May be afebrile due to immunosupression, have low treshhold for infectious work-up

	==See Also==		==See Also==

2016-09-05T19:51:32Z

← Older revision		Revision as of 19:51, 5 September 2016
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	*[[Lung transplant complications]]		*[[Lung transplant complications]]
	*[[Pancreas transplant complications]]		*[[Pancreas transplant complications]]
			*More severe or opportunistic infections due to immunocompromise

	==See Also==		==See Also==
			*[[Immunocompromised antibiotics]]

	==External Links==		==External Links==

2016-09-05T19:49:02Z

← Older revision		Revision as of 19:49, 5 September 2016
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	*Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)		*Transplanted organ frequency: kidney > liver > heart > lung > pancreas > other (combined and intestines)
	*Most transplant patients require lifelong immunosuppression		*Most transplant patients require lifelong immunosuppression

	~~{{Transplant emergency types}}~~

	===Epidemiology===		===Epidemiology===

2016-03-22T16:18:36Z

Text replacement - "Category:Surg" to "Category:Surgery"

2016-02-04T20:33:57Z

Complications Due to Immunosuppressant Medications

← Older revision		Revision as of 20:33, 4 February 2016
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	*Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant <ref>Tintinalli's</ref>		*Acute graft-versus-host disease occurs in 20% to 80% of patients post-hematopoietic stem cell transplantation (HSCT); rarely occurs in solid organ transplant <ref>Tintinalli's</ref>

	~~===Complications Due to~~ Immunosuppressant ~~Medications===~~		{{Immunosuppressant medication complications}}
	*Balance between immune suppression, rejection and susceptibility to infection
	*Typical regimen includes: calcineurin inhibitor + antimetabolite + steroid
	**Calcineurin inhibitor
	***Cyclosporine
	***Tacrolimus
	**Antimetabolite
	***Azathioprine
	***Mycophenolate Mofetil (MMF)
	**[[Steroids]]
	***[[Prednisone]]/[[Prednisolone]]

	==Types==		==Types==