ClaireLewis: Created page with "==Administration== Type: Diuretic Dosage Forms: Routes of Administration: oral Common Trade Names: Dyrenium ==Adult Dosing== Edema: 100-150 mg PO BID Hypertension:..."

2017-01-15T21:19:08Z

Created page with "==Administration== *Type: Diuretic *Dosage Forms: *Routes of Administration: oral *Common Trade Names: Dyrenium ==Adult Dosing== *Edema: 100-150 mg PO BID *Hypertension:..."

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==Administration==
*Type: [[Diuretic]]
*Dosage Forms:
*Routes of Administration: oral
*Common Trade Names: Dyrenium

==Adult Dosing==
*Edema: 100-150 mg PO BID
*Hypertension: 50-100 mg PO daily or in 2 divided doses

==Pediatric Dosing==
''Safety/efficacy not established''
*0.5-2 mg/kg PO BID, max daily dose 300mg

==Special Populations==
*[[Drug pregnancy categories|Pregnancy Rating]]: C
*Lactation risk: Infant risk cannot be ruled out
*Renal dosing:
**GFR >10: use 12h dosing interval
**GFR <110 or creatinine >2.5: use not recommended
*Hepatic dosing: contraindicated in severe liver impairment

==Contraindications==
*Allergy to class/drug
*Anuria, severe renal dysfunction
*Hyperkalemia
*Concomitant use of antikaliuretic agents, potassium supplementation/salt substitutes, or other potassium-sparing agents
*Severe liver disease

==Adverse Reactions==
===Serious===
*Hyperkalemia
*Azotemia, nephrotoxicity
*Jaundice
*Megaloblastic anemia
*Thrombocytopenia, purpura
*Anaphylaxis
===Common===
*Hyperuricemia, electrolyte abnormalities

==Pharmacology==
*Half-life: 1.5-6.5h
*Metabolism: Hepatic
*Excretion: <50% renal

==Mechanism of Action==
*Potassium-sparing diuretic: inhibits epithelial sodium channel in distal renal tubule

==Comments==

==See Also==
*[[Diuretics]]

==References==
<references/>

[[Category:Pharmacology]]

Triamterene - Revision history

ClaireLewis: Created page with "==Administration== *Type: Diuretic *Dosage Forms: *Routes of Administration: oral *Common Trade Names: Dyrenium ==Adult Dosing== *Edema: 100-150 mg PO BID *Hypertension:..."

ClaireLewis: Created page with "==Administration== Type: Diuretic Dosage Forms: Routes of Administration: oral Common Trade Names: Dyrenium ==Adult Dosing== Edema: 100-150 mg PO BID Hypertension:..."