Vitamin A toxicity - Revision history

Elcatracho: /* See Also */

2021-02-27T00:05:54Z

Elcatracho: /* Chronic toxicity */

2021-02-27T00:02:08Z

Chronic toxicity

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	===Chronic toxicity===		===Chronic toxicity===
	* Greater than x10 amount of RDA		* Greater than x10 amount of RDA
	* Symptoms include: skin irritation, alopecia [[arthralgias]]/bone pain, hyperlipidemia, [[hepatotoxicity]], [[ataxia]], [[visual loss\|visual impairment]],[[headache]] [[elevated ICP]]		* Symptoms include: skin irritation, alopecia [[arthralgias]]/bone pain, hyperlipidemia, [[hepatotoxicity]], [[ataxia]], [[visual loss\|visual impairment]], [[headache]], [[pseudotumor cerebri]], [[elevated ICP]]

	===Retinoic acid in 1st trimester===		===Retinoic acid in 1st trimester===
	*Very teratogenic		*Very teratogenic

ClaireLewis at 18:03, 17 August 2019

2019-08-17T18:03:57Z

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	#Smith FR, Goodman DS. Vitamin A transport in human vitamin A toxicity. N Engl J Med 1976; 294:805.		#Smith FR, Goodman DS. Vitamin A transport in human vitamin A toxicity. N Engl J Med 1976; 294:805.
	#Krasinski SD, Russell RM, Otradovec CL, et al. Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users. Am J Clin Nutr 1989; 49:112.		#Krasinski SD, Russell RM, Otradovec CL, et al. Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users. Am J Clin Nutr 1989; 49:112.
			[[category:Toxicology]]

ClaireLewis: /* Retinoic acid in 1st trimester */

2019-01-27T19:06:22Z

Retinoic acid in 1st trimester

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	* Greater than x10 amount of RDA		* Greater than x10 amount of RDA
	* Symptoms include: skin irritation, alopecia [[arthralgias]]/bone pain, hyperlipidemia, [[hepatotoxicity]], [[ataxia]], [[visual loss\|visual impairment]],[[headache]] [[elevated ICP]]		* Symptoms include: skin irritation, alopecia [[arthralgias]]/bone pain, hyperlipidemia, [[hepatotoxicity]], [[ataxia]], [[visual loss\|visual impairment]],[[headache]] [[elevated ICP]]
	===[[Retinoic acid]] in 1st trimester===		===Retinoic acid in 1st trimester===
	*Very teratogenic		*Very teratogenic
	**Spontaneous abortions and fetal malformation		**Spontaneous abortions and fetal malformation

ClaireLewis at 19:05, 27 January 2019

2019-01-27T19:05:44Z

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	===Chronic toxicity===		===Chronic toxicity===
	* Greater than x10 amount of RDA		* Greater than x10 amount of RDA
	* Symptoms include [[~~ataxia~~]]~~, alopecia~~, hyperlipidemia, [[hepatotoxicity]], ~~bone and muscle pain~~, [[visual loss\|visual impairment]]		* Symptoms include: skin irritation, alopecia [[arthralgias]]/bone pain, hyperlipidemia, [[hepatotoxicity]], [[ataxia]], [[visual loss\|visual impairment]],[[headache]] [[elevated ICP]]
			===[[Retinoic acid]] in 1st trimester===
	===~~Retanoic~~ acid in 1st trimester===
	*Very teratogenic		*Very teratogenic
	**Spontaneous abortions and fetal malformation		**Spontaneous abortions and fetal malformation
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	*Discontinue high vitamin A intake		*Discontinue high vitamin A intake
	**Most fully recover		**Most fully recover
	*Vitamin E supplementation		*Vitamin E supplementation
	*Liver transplant if necessary		*Manage complications of [[liver failure]]
			**Liver transplant may necessary in severe toxicity w/fulminant liver failure
			*Consider tox or [[poison control]] consult

	==Disposition==		==Disposition==
			*Dependant on severity

	==See Also==		==See Also==

ClaireLewis at 18:21, 27 January 2019

2019-01-27T18:21:29Z

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	==Background==		==Background==
	*Majority due to chronic ingestion of synthetic vitamin A		*Majority due to chronic ingestion of synthetic vitamin A
	**~~Approximately~~ 10x higher than Recommended Dietary Allowance (RDA), totaling ~50,000 units		**Toxic dose is approximately 10x higher than Recommended Dietary Allowance (RDA), totaling ~50,000 units
	*Provitamin A (beta-carotene) ingestion very unlikely to cause toxicity		*Provitamin A (beta-carotene) ingestion very unlikely to cause toxicity
	**Carotenemia common in children eating leafy green vegetables or carrots, with spontaneous resolution after cessation of foods		**Carotenemia common in children eating leafy green vegetables or carrots, with spontaneous resolution after cessation of foods
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	===Acute toxicity===		===Acute toxicity===
	*Single dose >660,000 IU (>200,000 micrograms)		*Single dose >660,000 IU (>200,000 micrograms)
	*Symptoms include nausea, vomiting, vertigo, blurry vision		*Symptoms include [[nausea/vomiting]], [[vertigo]], [[visual disturbances\|blurry vision]]

	===Chronic toxicity===		===Chronic toxicity===
	* Greater than x10 amount of RDA		* Greater than x10 amount of RDA
	* Symptoms include ataxia, alopecia, hyperlipidemia, hepatotoxicity, bone and muscle pain, visual impairment		* Symptoms include [[ataxia]], alopecia, hyperlipidemia, [[hepatotoxicity]], bone and muscle pain, [[visual loss\|visual impairment]]

	===Retanoic acid in 1st trimester===		===Retanoic acid in 1st trimester===

Rossdonaldson1: /* Clinical Features */

2018-10-22T02:27:38Z

Clinical Features

← Older revision		Revision as of 02:27, 22 October 2018
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	==Clinical Features==		==Clinical Features==
	*Acute toxicity		===Acute toxicity===
	**Single dose >660,000 IU (>200,000 micrograms)		*Single dose >660,000 IU (>200,000 micrograms)
	**Symptoms include nausea, vomiting, vertigo, blurry vision		*Symptoms include nausea, vomiting, vertigo, blurry vision
	*Chronic toxicity
	** Greater than x10 amount of RDA		===Chronic toxicity===
	** Symptoms include ataxia, alopecia, hyperlipidemia, hepatotoxicity, bone and muscle pain, visual impairment		* Greater than x10 amount of RDA
	*Retanoic acid ~~very teratogenic~~ in 1st trimester		* Symptoms include ataxia, alopecia, hyperlipidemia, hepatotoxicity, bone and muscle pain, visual impairment

			===Retanoic acid in 1st trimester===
			*Very teratogenic
	**Spontaneous abortions and fetal malformation		**Spontaneous abortions and fetal malformation
	**Vitamin A in pregnancy safe upper limit 10,000IU		**Vitamin A in pregnancy safe upper limit 10,000IU

	==Differential Diagnosis==		==Differential Diagnosis==

Rossdonaldson1: /* See Also */

2018-10-22T02:25:48Z

Rossdonaldson1 at 02:24, 22 October 2018

2018-10-22T02:24:53Z

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	**Spontaneous abortions and fetal malformation		**Spontaneous abortions and fetal malformation
	**Vitamin A in pregnancy safe upper limit 10,000IU		**Vitamin A in pregnancy safe upper limit 10,000IU

			==Differential Diagnosis==

	==Evaluation==		==Evaluation==
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	*Vitamin E supplementation		*Vitamin E supplementation
	*Liver transplant if necessary		*Liver transplant if necessary

			==Disposition==


			==See Also==


			==External Links==


	==References==		==References==
			<references/>
	#McCuaig LW, Motzok I (July 1970). "Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity". Poultry Science. 49 (4): 1050–1. doi:10.3382/ps.0491050. PMID 5485475.		#McCuaig LW, Motzok I (July 1970). "Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity". Poultry Science. 49 (4): 1050–1. doi:10.3382/ps.0491050. PMID 5485475.
	#Soprano DR, Soprano KJ. Retinoids as teratogens. Annu Rev Nutr 1995; 15:111.		#Soprano DR, Soprano KJ. Retinoids as teratogens. Annu Rev Nutr 1995; 15:111.

Rossdonaldson1 at 02:23, 22 October 2018

2018-10-22T02:23:52Z

← Older revision		Revision as of 02:23, 22 October 2018
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	==References==		==References==
			#McCuaig LW, Motzok I (July 1970). "Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity". Poultry Science. 49 (4): 1050–1. doi:10.3382/ps.0491050. PMID 5485475.
	1. McCuaig LW, Motzok I (July 1970). "Excessive dietary vitamin E: its alleviation of hypervitaminosis A and lack of toxicity". Poultry Science. 49 (4): 1050–1. doi:10.3382/ps.0491050. PMID 5485475.		#Soprano DR, Soprano KJ. Retinoids as teratogens. Annu Rev Nutr 1995; 15:111.
			#Mahoney CP, Margolis MT, Knauss TA, Labbe RF. Chronic vitamin A intoxication in infants fed chicken liver. Pediatrics 1980; 65:893.
	2. Soprano DR, Soprano KJ. Retinoids as teratogens. Annu Rev Nutr 1995; 15:111.		#Lam HS, Chow CM, Poon WT, et al. Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children. Pediatrics 2006; 118:820.
			#Cheruvattath R, Orrego M, Gautam M, et al. Vitamin A toxicity: when one a day doesn't keep the doctor away. Liver Transpl 2006; 12:1888.
	3. Mahoney CP, Margolis MT, Knauss TA, Labbe RF. Chronic vitamin A intoxication in infants fed chicken liver. Pediatrics 1980; 65:893.		#Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr 2006; 83:191.
			#Smith FR, Goodman DS. Vitamin A transport in human vitamin A toxicity. N Engl J Med 1976; 294:805.
	4. Lam HS, Chow CM, Poon WT, et al. Risk of vitamin A toxicity from candy-like chewable vitamin supplements for children. Pediatrics 2006; 118:820.		#Krasinski SD, Russell RM, Otradovec CL, et al. Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users. Am J Clin Nutr 1989; 49:112.

	5. Cheruvattath R, Orrego M, Gautam M, et al. Vitamin A toxicity: when one a day doesn't keep the doctor away. Liver Transpl 2006; 12:1888.

	6. Penniston KL, Tanumihardjo SA. The acute and chronic toxic effects of vitamin A. Am J Clin Nutr 2006; 83:191.

	7. Smith FR, Goodman DS. Vitamin A transport in human vitamin A toxicity. N Engl J Med 1976; 294:805.

	8. Krasinski SD, Russell RM, Otradovec CL, et al. Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users. Am J Clin Nutr 1989; 49:112.

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	==See Also==		==See Also==
	*[[Vitamin A deficiency]]		*[[Vitamin A deficiency]]
			*[[Pseudotumor cerebri]]

	==External Links==		==External Links==

← Older revision		Revision as of 02:25, 22 October 2018
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	==See Also==		==See Also==
			*[[Vitamin A deficiency]]

	==External Links==		==External Links==