Xylazine toxicity - Revision history

Rossdonaldson1: /* Differential Diagnosis */

2023-03-15T15:45:17Z

Differential Diagnosis

← Older revision		Revision as of 15:45, 15 March 2023
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	==Differential Diagnosis==		==Differential Diagnosis==
	*See [[Hypotension]]
	{{Sedatve/hypnotic toxicity types}}		{{Sedatve/hypnotic toxicity types}}
	{{Symptomatic bradycardia}}		{{Symptomatic bradycardia}}

Rossdonaldson1: /* Differential Diagnosis */

2023-03-15T15:43:01Z

Differential Diagnosis

← Older revision		Revision as of 15:43, 15 March 2023
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	==Differential Diagnosis==		==Differential Diagnosis==
	*See ~~[[Bradycardia]],~~ [[Hypotension]]		*See [[Hypotension]]
	{{Sedatve/hypnotic toxicity types}}		{{Sedatve/hypnotic toxicity types}}
			{{Symptomatic bradycardia}}

	==Evaluation==		==Evaluation==

Rossdonaldson1: /* See Also */

2023-03-15T15:41:52Z

Rossdonaldson1: /* Background */

2023-03-15T15:41:20Z

Background

← Older revision		Revision as of 15:41, 15 March 2023
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	*Veterinary sedative, anesthetic, analgesic, and muscle relaxant		*Veterinary sedative, anesthetic, analgesic, and muscle relaxant
	*Human drug of abuse, usually as drug adulterant without the knowledge of people who use these drugs		*Human drug of abuse, usually as drug adulterant without the knowledge of people who use these drugs
	**<u>Not</u> an opioid, but often combined with opioids and increases the risk of overdose and death		**<u>Not</u> an opioid, but often combined with [[opioids]] and increases the risk of overdose and death
	**Associated with complex skin infections when injected		**Associated with complex [[skin infections]] when injected

	==Clinical Features==		==Clinical Features==

Rossdonaldson1 at 15:41, 15 March 2023

2023-03-15T15:41:00Z

← Older revision		Revision as of 15:41, 15 March 2023
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	==Background==		==Background==
	*Analogue of [[clonidine]] and agonist at [[alpha-2 agonists\|alpha 2 adrenergic receptor]]		*Also known as "Tranq"
			*Analogue of [[clonidine]] and agonist at [[alpha-2 agonists\|alpha 2 adrenergic receptor]]<ref>https://www.ncbi.nlm.nih.gov/pubmed/24769343</ref>
	*Veterinary sedative, anesthetic, analgesic, and muscle relaxant		*Veterinary sedative, anesthetic, analgesic, and muscle relaxant
	*Human drug of abuse, usually as drug adulterant		*Human drug of abuse, usually as drug adulterant without the knowledge of people who use these drugs
			**<u>Not</u> an opioid, but often combined with opioids and increases the risk of overdose and death
			**Associated with complex skin infections when injected

	==Clinical Features==		==Clinical Features==
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	*Evaluate for alternate etiologies		*Evaluate for alternate etiologies
	*Clinical diagnosis		*Clinical diagnosis
			*Consider collecting serum toxicology tests specifically for xylazine, if available (for public health reasons; does not affect acute management)

	==Management==		==Management==
	*Supportive: address airway/respiratory drive/blood pressure, [[atropine]] for bradycardia		*Supportive: address airway/respiratory drive/blood pressure, [[atropine]] for bradycardia
			*Consider administration of [[naloxone]] due to high likelihood that opioids are also present (does not directly affect xylazine toxicity)

	==Disposition==		==Disposition==
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	==References==		==References==
	~~https://www.ncbi.nlm.nih.gov/pubmed/24769343~~
	<references/>		<references/>
	[[Category:Toxicology]]		[[Category:Toxicology]]

ClaireLewis: /* Clinical Features */

2019-08-21T19:46:25Z

Clinical Features

← Older revision		Revision as of 19:46, 21 August 2019
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	==Clinical Features==		==Clinical Features==
	*[[Bradycardia]]		*[[Bradycardia]]
	*[[Respiratory depression]]		*Respiratory depression
	*[[Hypotension]]		*[[Hypotension]]

ClaireLewis at 19:46, 21 August 2019

2019-08-21T19:46:07Z

← Older revision		Revision as of 19:46, 21 August 2019
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	==Background==		==Background==
	*~~analogue~~ of clonidine and agonist at alpha 2 adrenergic receptor		*Analogue of [[clonidine]] and agonist at [[alpha-2 agonists\|alpha 2 adrenergic receptor]]
	*~~used for sedation~~, ~~anesthesia~~, muscle ~~relaxation and analgesia in animals~~		*Veterinary sedative, anesthetic, analgesic, and muscle relaxant
	*~~used as~~ drug of abuse, usually drug adulterant		*Human drug of abuse, usually as drug adulterant

	==Clinical Features==		==Clinical Features==
	*~~bradycardia~~		*[[Bradycardia]]
	*~~respiratory~~ depression		*[[Respiratory depression]]
	*~~hypotension~~		*[[Hypotension]]

	==Differential Diagnosis==		==Differential Diagnosis==
	*~~other ingestions of sedative~~ hypnotic ~~agents~~		*See [[Bradycardia]], [[Hypotension]]
			{{Sedatve/hypnotic toxicity types}}

	==Evaluation==		==Evaluation==
			*Evaluate for alternate etiologies
			*Clinical diagnosis

	==Management==		==Management==
	*~~maintain~~ respiratory ~~function and~~ blood pressure, atropine for bradycardia		*Supportive: address airway/respiratory drive/blood pressure, [[atropine]] for bradycardia

	==Disposition==		==Disposition==
	*~~admit for further monitoring~~		*Admit if not back to baseline

	==See Also==		==See Also==
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	https://www.ncbi.nlm.nih.gov/pubmed/24769343		https://www.ncbi.nlm.nih.gov/pubmed/24769343
	<references/>		<references/>
			[[Category:Toxicology]]

Gregtong: Created page with "==Background== analogue of clonidine and agonist at alpha 2 adrenergic receptor used for sedation, anesthesia, muscle relaxation and analgesia in animals *used as drug of ab..."

2019-08-21T01:34:25Z

Created page with "==Background== *analogue of clonidine and agonist at alpha 2 adrenergic receptor *used for sedation, anesthesia, muscle relaxation and analgesia in animals *used as drug of ab..."

New page

==Background==
*analogue of clonidine and agonist at alpha 2 adrenergic receptor
*used for sedation, anesthesia, muscle relaxation and analgesia in animals
*used as drug of abuse, usually drug adulterant

==Clinical Features==
*bradycardia
*respiratory depression
*hypotension

==Differential Diagnosis==
*other ingestions of sedative hypnotic agents

==Evaluation==

==Management==
*maintain respiratory function and blood pressure, atropine for bradycardia

==Disposition==
*admit for further monitoring

==See Also==

==External Links==

==References==
https://www.ncbi.nlm.nih.gov/pubmed/24769343
<references/>

← Older revision		Revision as of 15:41, 15 March 2023
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	==See Also==		==See Also==
			*[[Sedative/hypnotic toxicity]]

	==External Links==		==External Links==

Xylazine toxicity - Revision history

Rossdonaldson1: /* Differential Diagnosis */

Rossdonaldson1: /* Differential Diagnosis */

Rossdonaldson1: /* See Also */

Rossdonaldson1: /* Background */

Rossdonaldson1 at 15:41, 15 March 2023

ClaireLewis: /* Clinical Features */

ClaireLewis at 19:46, 21 August 2019

Gregtong: Created page with "==Background== *analogue of clonidine and agonist at alpha 2 adrenergic receptor *used for sedation, anesthesia, muscle relaxation and analgesia in animals *used as drug of ab..."

Gregtong: Created page with "==Background== analogue of clonidine and agonist at alpha 2 adrenergic receptor used for sedation, anesthesia, muscle relaxation and analgesia in animals *used as drug of ab..."