Torsemide: Difference between revisions
(Text replacement - " P450" to "P450") |
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==Pharmacology== | ==Pharmacology== | ||
*Half-life: 2-4 hours | *Half-life: 2-4 hours | ||
*Metabolism: P450 | *Metabolism:[[P450]] | ||
*Excretion: Renal | *Excretion: Renal | ||
Revision as of 11:58, 24 September 2016
Administration
- Type: Loop diuretic
- Dosage Forms:
- Routes of Administration: IV, PO
- Common Trade Names: Demadex
Adult Dosing
40mg furosemide = 20mg torsemide = 1mg bumetanide
- 5-200 mg PO or IV daily. Titrate to effect by doubling dose
Pediatric Dosing
Safety/efficacy not established
Special Populations
- Pregnancy Rating: B
- Lactation risk: Infant risk cannot be ruled out
Renal dosing: no adjustment Hepatic dosing: no adjustment
Contraindications
- Allergy to class/drug
- Anuria
Adverse Reactions
Serious
- Ventricular tachycardia
- SJS/TEN
- Ototoxicity
Common
- Polyuria
- Rhinitis
Pharmacology
- Half-life: 2-4 hours
- Metabolism:P450
- Excretion: Renal
Mechanism of Action
- Loop diuretic: interferes with Na/K/Cl cotransport system, inhibiting reabsorption of Na/Cl in the ascending limb of the loop of Henle