Phenylephrine: Difference between revisions
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==Notes== | ==Notes== | ||
*Use with caution in patients with spinal cord injury-related bradycardia | *Use with caution in patients with spinal cord injury-related bradycardia | ||
*Useful for treatment of vasodilatory shock when norepinephrine or dopamine have precipitated tachyarrhythmias | *Useful for treatment of vasodilatory shock when norepinephrine or [[dopamine]] have precipitated tachyarrhythmias | ||
*In patients with ↓LV function, unopposed α1 may lead to decreased CO or myocardial ischemia | *In patients with ↓LV function, unopposed α1 may lead to decreased CO or myocardial ischemia | ||
**However clinical trials do not support these effects when used in clinically appropriate dose range | **However clinical trials do not support these effects when used in clinically appropriate dose range | ||
Revision as of 12:34, 19 December 2016
General
- Type: Vasopressors
- Dosage Forms:
- Common Trade Names:
Adult Dosing
Dosing
- Start 100-200mcg/min then taper down
- 40-60mcg/min works for most
Pediatric Dosing
Special Populations
- Pregnancy Rating: C
- Lactation: infant risk cannot be ruled out
- Renal Dosing
- Adult
- Pediatric
- Hepatic Dosing
- Adult
- Pediatric
Contraindications
- Allergy to class/drug
Adverse Reactions
- Baroreceptor-mediated reflex bradycardia
- If extravasates use phentolamine
Serious
Common
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Primary Receptor
- α1
Relative Effects
- ↑SVR
- ↓HR (reflex bradycardia)
Notes
- Use with caution in patients with spinal cord injury-related bradycardia
- Useful for treatment of vasodilatory shock when norepinephrine or dopamine have precipitated tachyarrhythmias
- In patients with ↓LV function, unopposed α1 may lead to decreased CO or myocardial ischemia
- However clinical trials do not support these effects when used in clinically appropriate dose range
Indication
- Neurogenic Shock