Extravascular hemolytic transfusion reaction

Background

• Occurs days to weeks after transfusion

Clinical Features

• Hemolysis occurs in spleen, liver, and bone marrow

Differential Diagnosis

Transfusion Reaction Types

• Acute
  • Intravascular hemolytic tranfusion reaction
  • Febrile nonhemolytic tranfusion reaction
  • Allergic tranfusion reaction
  • Transfusion-associated circulatory overload (TACO)
  • Transfusion-related acute lung injury (TRALI)
  • Transfusion-associated graft-versus-host disease
  • Fluid overload
  • Sepsis
• Delayed
  • Extravascular hemolytic tranfusion reaction
  • Graft-vs-host disease
  • Transfusion infections

Evaluation

• Hyperbilirubinemia
• Poor response to transfusion

Management

• None necessary; rarely fatal

See Also

• Transfusions
• Acute transfusion reaction
• Extravascular hemolytic tranfusion reaction
• Graft-vs-host disease