Cadmium toxicity: Difference between revisions
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*Used in electroplating, soldering, pigments, and plastics | *Used in electroplating, soldering, pigments, and plastics | ||
==Mechanism of Toxicity== | ===Mechanism of Toxicity=== | ||
*Inhaled form is 60 times more toxic than ingested form | *Inhaled form is 60 times more toxic than ingested form | ||
*Chemical pneumonitis | *Chemical pneumonitis | ||
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*Renal tubule damage | *Renal tubule damage | ||
==Clinical | ==Clinical Features== | ||
*Local skin and eye irritation | *Local skin and eye irritation | ||
*Cough, wheezing, pulmonary edema | *Cough, wheezing, [[pulmonary edema]] | ||
*Nausea, vomiting, diarrhea | *[[Nausea]], [[vomiting]], [[diarrhea]] | ||
*Chronic exposure can lead to bone deposition and "itai-itai" disease | *Chronic exposure can lead to bone deposition and "itai-itai" disease | ||
==Differential Diagnosis== | |||
==Diagnosis== | ==Diagnosis== | ||
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==Management== | ==Management== | ||
===Inhalation=== | |||
*Supplemental oxygen | |||
*Monitor [[ABG]], check [[CXR]] | |||
*Treat wheezing and pulmonary edema | |||
* | ===Ingestion=== | ||
*[[Activated charcoal]] or lavage | |||
*Volume resuscitation to counter fluid losses | |||
*No role for hemodialysis | *No role for hemodialysis | ||
==Disposition== | ==Disposition== | ||
Revision as of 09:46, 27 April 2017
Background
- Used in electroplating, soldering, pigments, and plastics
Mechanism of Toxicity
- Inhaled form is 60 times more toxic than ingested form
- Chemical pneumonitis
- Pulmonary edema/hemorrhage
- GI irritation
- Renal tubule damage
Clinical Features
- Local skin and eye irritation
- Cough, wheezing, pulmonary edema
- Nausea, vomiting, diarrhea
- Chronic exposure can lead to bone deposition and "itai-itai" disease
Differential Diagnosis
Diagnosis
- History of exposure and respiratory / gastrointestinal complaints
Management
Inhalation
Ingestion
- Activated charcoal or lavage
- Volume resuscitation to counter fluid losses
- No role for hemodialysis
Disposition
See Also
References
Olson, K. Poisoning and Drug Overdose, 1999.