Amantadine

Administration

• Type: Antiviral, anticholinergics
• Dosage Forms:
• Routes of Administration: Oral
• Common Trade Names:

Adult Dosing

Influenza A

• 100 mg BID or 200 mg daily PO

Parkinsonism, extrapyramidal disease

• 100-200 mg BID

Pediatric Dosing

Influenza, 1-9 years old

• 2.2-4.4 mg/kg PO BID

Influenza, >9 years old

• 100 mg PO BID

Neuroleptic malignant syndrome=

• 100mg PO initially
• Titrate up as needed to max dose 200mg q12hr

Special Populations

• Pregnancy Rating: C
• Lactation risk: Infant risk cannot be ruled out
• Renal dosing:
  • CrCl 30-50 mL/min: 200 mg PO on first day, then 100 mg/day
  • CrCl 15-29 mL/min: 200 mg PO on first day, then 100 mg every other day
  • CrCl <15 mL/min or on HD: 200mg weekly
• Hepatic dosing: not defined

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• CHF, hypotension, dysrhythmia, tachycardia, cardiac arrest
• Pulmonary edema, acute respiratory failure
• Malignant melanoma
• Leukopenia, agranulocytosis, neutropenia
• Neuroleptic malignant syndrome
• Suicidal ideation

Common

• Nausea, diarrhea, constipation, lack of appetite
• Headache
• Fatigue, dizziness, confusion, ataxia
• Anxiety, insomnia, depression, irritability, hallucinations, dream disorder
• Orthostatic hypotension
• Peripheral edema

Pharmacology

• Half-life: 10-25h
• Metabolism:
• Excretion: Renal

Mechanism of Action

• Interferes with the function of viral M2 protein, preventing release of viral nucleic acids into host cell

See Also

• Influenza