Fresh frozen plasma: Difference between revisions
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*Dosage Forms: | *Dosage Forms: | ||
*Common Trade Names: | *Common Trade Names: | ||
==Indications== | |||
*Rapid reversal of warfarin anticoagulation (in setting of bleeding or need for invasive procedure) | |||
*Bleeding and multiple coagulation defects (e.g. DIC with significant PT/PTT elevation) | |||
*Correction of coagulation defects for which no specific factor is available | |||
*Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy | |||
==Adult Dosing== | ==Adult Dosing== | ||
*1 bag = 1 unit = 250 mL | |||
*10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30% | |||
*Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult) | *Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult) | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Neonates/small children: 10-20 mL/kg will increase factor levels by 15-25% | |||
==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: | *[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C | ||
*Lactation: | *Lactation: | ||
*Renal Dosing | *Renal Dosing: | ||
*Hepatic Dosing: | |||
*Hepatic Dosing | |||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
*ABO incompatibility | |||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Hemolytic transfusion reactions | |||
*Febrile non-hemolytic reactions | |||
*Transfusion-associated circulatory overload (TACO) | |||
*Transfusion-related acute lung injury (TRALI) | |||
*Transfusion-associated graft-versus-host disease | |||
*Anaphylaxis | |||
*Sepsis | |||
===Common=== | ===Common=== | ||
*Headache, paresthesia | |||
*Nausea | |||
*Pruritus, urticaria | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 22:14, 11 August 2017
General
- Type: Blood products
- Dosage Forms:
- Common Trade Names:
Indications
- Rapid reversal of warfarin anticoagulation (in setting of bleeding or need for invasive procedure)
- Bleeding and multiple coagulation defects (e.g. DIC with significant PT/PTT elevation)
- Correction of coagulation defects for which no specific factor is available
- Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy
Adult Dosing
- 1 bag = 1 unit = 250 mL
- 10-20 mL/kg (4-6 units in 70kg adult) will increase factors by ~20-30%
- Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)
Pediatric Dosing
- Neonates/small children: 10-20 mL/kg will increase factor levels by 15-25%
Special Populations
- Pregnancy Rating: C
- Lactation:
- Renal Dosing:
- Hepatic Dosing:
Contraindications
- Allergy to class/drug
- ABO incompatibility
Adverse Reactions
Serious
- Hemolytic transfusion reactions
- Febrile non-hemolytic reactions
- Transfusion-associated circulatory overload (TACO)
- Transfusion-related acute lung injury (TRALI)
- Transfusion-associated graft-versus-host disease
- Anaphylaxis
- Sepsis
Common
- Headache, paresthesia
- Nausea
- Pruritus, urticaria
Pharmacology
- Half-life:
- Metabolism:
- Excretion:
- Mechanism of Action:
Comments
- Contains all coagulation factors and fibrinogen
- 40 mL/kg raises any factor by 100% (each unit is ~200mL)
- May cause fluid overload
- ABO compatibilty a must but crossmatch before transfusing not
- INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised[1]
- Retains active coagulation factors for up to 5 days after being thawed
See Also
References
- ↑ Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9.