Template:Antibiotics Open Fracture: Difference between revisions
No edit summary |
|||
| Line 2: | Line 2: | ||
====Grade I Fracture Options==== | ====Grade I Fracture Options==== | ||
*[[Cefazolin]] (Ancef) 2g IV | *[[Cefazolin]] (Ancef) 2g IV TID | ||
*[[Ciprofloxacin]] 400mg IV BID (avoid in pediatrics) | *[[Ciprofloxacin]] 400mg IV BID (avoid in pediatrics) | ||
| Line 8: | Line 8: | ||
*Add [[Gentamicin]] 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins | *Add [[Gentamicin]] 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins | ||
**Once daily dosing has been shown to be safe and effective | **Once daily dosing has been shown to be safe and effective | ||
*If concern for [[Clostridium]] then consider single drug regimen of [[Pipericillin/Tazobactam]] 4.5g (80mg/kg) IV | *If concern for [[Clostridium]] then consider single drug regimen of [[Pipericillin/Tazobactam]] 4.5g (80mg/kg) IV TID | ||
Revision as of 20:18, 19 August 2017
- NNT 12.5 to prevent early fracture site infection[1]
Grade I Fracture Options
- Cefazolin (Ancef) 2g IV TID
- Ciprofloxacin 400mg IV BID (avoid in pediatrics)
Grade II/III Fracture Options
- Add Gentamicin 300 mg (1-1.7mg/kg) IV to any of the Grade I regemins
- Once daily dosing has been shown to be safe and effective
- If concern for Clostridium then consider single drug regimen of Pipericillin/Tazobactam 4.5g (80mg/kg) IV TID
- ↑ Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.